专利检索 ap:("The United States of America, as represented by the Secretary, Department of Health AND Human Services") AND inv:"ZHOU, Tongqing" 第 2 页

11.

发明公开
NEUTRALIZING ANTIBODIES TO GP120 AND THEIR USE 审中-公开
标题翻译：中和抗GP120抗体及其用途

公开(公告)号：EP3271389A1

公开(公告)日：2018-01-24

申请号：EP16716979.6

申请日：2016-03-18

申请人： The United States of America, as Represented by the Secretary Department of Health and Human Services

发明人： CONNORS, Mark , HUANG, Jinghe , KANG, Byong, Ha , MASCOLA, John , ISHIDA, Elise , ZHOU, Tongqing , KWONG, Peter , ZHENG, Anqi

IPC分类号： C07K16/10 , A61P31/18

CPC分类号： C07K16/1063 , A61K2039/505 , A61K2039/545 , A61P31/18 , C07K16/2809 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/52 , C07K2317/76 , G01N33/56988 , G01N2333/162 , G01N2800/26

摘要： Antibodies and antigen binding fragments that specifically bind to gp120 and neutralize HIV-1 are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.

12.

发明公开
EPITOPE-PROTEIN SCAFFOLDS AND THEIR USE 审中-公开
标题翻译：表位的蛋白质支架及其用途

公开(公告)号：EP2062180A2

公开(公告)日：2009-05-27

申请号：EP07841376.2

申请日：2007-08-24

申请人： The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services , The University of Washington

发明人： KWONG, Peter , OFEK, Gilad , GUENAGA, Javier , WYATT, Richard, T. , YANG, Zhi-yong , ZHOU, Tongqing , NABEL, Gary , TANG, Min , SCHIEF, William , BAKER, David

IPC分类号： G06F19/00

CPC分类号： G06F19/16

摘要： Computational protocols for the design of epitope-protein scaffolds which elicit selected neutralizing antibodies are disclosed, and related compositions and uses.