公开(公告)号：EP3271389B8

公开(公告)日：2020-04-22

申请号：EP16716979.6

申请日：2016-03-18

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： CONNORS, Mark ,  HUANG, Jinghe ,  KANG, Byong, Ha ,  MASCOLA, John ,  ISHIDA, Elise ,  ZHOU, Tongqing ,  KWONG, Peter ,  ZHENG, Anqi

IPC分类号： C07K16/10 ,  A61P31/18

公开(公告)号：EP3271389B1

公开(公告)日：2020-02-12

申请号：EP16716979.6

申请日：2016-03-18

申请人： The United States of America, as Represented by the Secretary Department of Health and Human Services

发明人： CONNORS, Mark ,  HUANG, Jinghe ,  KANG, Byong, Ha ,  MASCOLA, John ,  ISHIDA, Elise ,  ZHOU, Tongqing ,  KWONG, Peter ,  ZHENG, Anqi

IPC分类号： C07K16/10 ,  A61P31/18

公开(公告)号：EP3271389A1

公开(公告)日：2018-01-24

申请号：EP16716979.6

申请日：2016-03-18

申请人： The United States of America, as Represented by the Secretary Department of Health and Human Services

发明人： CONNORS, Mark ,  HUANG, Jinghe ,  KANG, Byong, Ha ,  MASCOLA, John ,  ISHIDA, Elise ,  ZHOU, Tongqing ,  KWONG, Peter ,  ZHENG, Anqi

IPC分类号： C07K16/10 ,  A61P31/18

CPC分类号： C07K16/1063 ,  A61K2039/505 ,  A61K2039/545 ,  A61P31/18 ,  C07K16/2809 ,  C07K16/468 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/76 ,  G01N33/56988 ,  G01N2333/162 ,  G01N2800/26

摘要： Antibodies and antigen binding fragments that specifically bind to gp120 and neutralize HIV-1 are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.