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公开(公告)号：EP2776463A1
公开(公告)日：2014-09-17
申请号：EP12847241.2
申请日：2012-11-07
发明人： CONNORS, Mark , HUANG, Jinghe , LAUB, Leo, B. , KWONG, Peter , NABEL, Gary , MASCOLA, John, R. , ZHANG, Baoshan , RUDICELL, Rebecca, S. , GEORGIEV, Ivelin , YANG, Yongping , ZHU, Jiang , OFEK, Gilad
CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , A61K49/0004 , A61K2039/505 , C07K16/00 , C07K16/1045 , C07K2317/14 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , G01N33/56972 , G01N33/56983 , G01N33/56988 , G01N2333/161
摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the HIV-1 gp41 membrane-proximal external region (MPER). Also disclosed are compositions including the disclosed antibodies that specifically bind gp41, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of HIV-1 in a biological sample, or detecting an HIV-1 infection or diagnosing AIDS in a subject. In additional, the broad neutralization breadth of the disclosed antibodies makes them ideal for treating a subject with an HIV infection. Thus, disclosed are methods of treating and/or preventing HIV infection.
摘要翻译： 公开了特异性结合HIV-1 gp41膜近端外部区域（MPER）的单克隆中和抗体。 还公开了包括所公开的特异性结合gp41的抗体，编码这些抗体的核酸，包括核酸的表达载体和表达核酸的分离的宿主细胞的组合物。 本文公开的抗体和组合物可用于检测生物样品中HIV-1的存在，或检测受试者中的HIV-1感染或AIDS的诊断。 此外，所公开抗体的广泛中和宽度使其成为治疗HIV感染的受试者的理想选择。 因此，公开了治疗和/或预防HIV感染的方法。
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公开(公告)号：EP4277656A1
公开(公告)日：2023-11-22
申请号：EP22703165.5
申请日：2022-01-14
发明人： CONNORS, Mark
IPC分类号： A61K39/215
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公开(公告)号：EP4011911A1
公开(公告)日：2022-06-15
申请号：EP21204045.5
申请日：2016-11-03
申请人： The United States of America as represented by The Secretary Department of Health and Human Services , The Trustees of Columbia University in the City of New York
发明人： KWONG, Peter , KWON, Young Do , GEORGIEV, Ivelin , OFEK, Gilad , ZHANG, Baoshan , MCKEE, Krisha , MACSOLA, John , CHUANG, Gwo-Yu , O'DELL, Sijy , GINDIN, Tatyana , SHAPIRO, Lawrence , BAILER, Robert , LOUDER, Mark , ASOKAN, Mangaiarkarasi , SCHWARTZ, Richard , COOPER, Jonathan , CARLTON, Kevin , BENDER, Michael , CONNORS, Mark , PEGU, Amarendra , KUELTZO, Lisa
IPC分类号： C07K16/10
摘要： Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.
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公开(公告)号：EP3271389B8
公开(公告)日：2020-04-22
申请号：EP16716979.6
申请日：2016-03-18
发明人： CONNORS, Mark , HUANG, Jinghe , KANG, Byong, Ha , MASCOLA, John , ISHIDA, Elise , ZHOU, Tongqing , KWONG, Peter , ZHENG, Anqi
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公开(公告)号：EP2480572B1
公开(公告)日：2019-01-30
申请号：EP10760878.8
申请日：2010-09-24
申请人： The United States of America, as represented by The Secretary, Department of Health and Human Services , University of Washington through its Center for Commercialization
发明人： MASCOLA, John, R. , WYATT, Richard , WU, Xueling , LI, Yuxing , HOGERKORP, Carl-Magnus , ROEDERER, Mario , YANG, Zhi-yong , NABEL, Gary , KWONG, Peter , ZHOU, Tongqing , CONNORS, Mark , OFEK, Gilad , SHAPIRO, Lawrence , ZHU, Jiang , SCHIEF, William R.
IPC分类号： C07K16/10
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公开(公告)号：EP2828294A1
公开(公告)日：2015-01-28
申请号：EP13763664.3
申请日：2013-03-15
发明人： MASCOLA, John, R. , LYNCH, Rebecca, M. , WU, Xueling , CONNORS, Mark , ZHOU, Tongqing , CASAZZA, Joseph , KWONG, Peter, D.
CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , A61K49/0004 , A61K2039/505 , A61K2039/545 , C07K2317/31 , C07K2317/76 , G01N33/56983
摘要： Neutralizing antibodies that specifically bind to HIV-1 gpl20 and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV infection is disclosed.
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公开(公告)号：EP3271389B1
公开(公告)日：2020-02-12
申请号：EP16716979.6
申请日：2016-03-18
发明人： CONNORS, Mark , HUANG, Jinghe , KANG, Byong, Ha , MASCOLA, John , ISHIDA, Elise , ZHOU, Tongqing , KWONG, Peter , ZHENG, Anqi
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8.发明公开INDUCTION OF PROLIFERATION, EFFECTOR MOLECULE EXPRESSION, AND CYTOLYTIC CAPACITY OF HIV-SPECIFIC CD8+ T CELLS 审中-公开HIV特异性CD8 + T细胞的增殖诱导，效应分子表达和细胞毒性
公开(公告)号：EP2271333A2
公开(公告)日：2011-01-12
申请号：EP09762793.9
申请日：2009-03-25
IPC分类号： A61K31/235 , A61P37/00 , A61P31/18 , A61K33/06 , A61K31/555
CPC分类号： A61K31/235 , A61K31/555 , A61K35/17 , A61K2035/124 , C12N5/0636 , C12N2500/14 , C12N2501/999 , A61K2300/00
摘要： Provided is a method of activating an immune cell of a subject with Human Immunodeficiency Virus (HIV), comprising contacting the immune cell with a phorbol ester and a calcium ionophore. Also provided is a composition comprising immune cells of a subject diagnosed with HIV, wherein the immune cells are activated by contact with a phorbol ester and a calcium ionophore. Methods of using the disclosed compositions are also disclosed.
摘要翻译： 提供了用人免疫缺陷病毒（HIV）活化受试者的免疫细胞的方法，包括使免疫细胞与佛波醇酯和钙离子载体接触。 还提供了包含诊断为HIV的受试者的免疫细胞的组合物，其中所述免疫细胞通过与佛波醇酯和钙离子载体接触而被活化。 还公开了使用所公开的组合物的方法。
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公开(公告)号：EP3271389A1
公开(公告)日：2018-01-24
申请号：EP16716979.6
申请日：2016-03-18
发明人： CONNORS, Mark , HUANG, Jinghe , KANG, Byong, Ha , MASCOLA, John , ISHIDA, Elise , ZHOU, Tongqing , KWONG, Peter , ZHENG, Anqi
CPC分类号： C07K16/1063 , A61K2039/505 , A61K2039/545 , A61P31/18 , C07K16/2809 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/52 , C07K2317/76 , G01N33/56988 , G01N2333/162 , G01N2800/26
摘要： Antibodies and antigen binding fragments that specifically bind to gp120 and neutralize HIV-1 are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.
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公开(公告)号：EP2776463B1
公开(公告)日：2017-09-20
申请号：EP12847241.2
申请日：2012-11-07
发明人： CONNORS, Mark , HUANG, Jinghe , LAUB, Leo, B. , KWONG, Peter , NABEL, Gary , MASCOLA, John, R. , ZHANG, Baoshan , RUDICELL, Rebecca, S. , GEORGIEV, Ivelin , YANG, Yongping , ZHU, Jiang , OFEK, Gilad
CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , A61K49/0004 , A61K2039/505 , C07K16/00 , C07K16/1045 , C07K2317/14 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , G01N33/56972 , G01N33/56983 , G01N33/56988 , G01N2333/161
摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the HIV-1 gp41 membrane-proximal external region (MPER). Also disclosed are compositions including the disclosed antibodies that specifically bind gp41, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of HIV-1 in a biological sample, or detecting an HIV-1 infection or diagnosing AIDS in a subject. In additional, the broad neutralization breadth of the disclosed antibodies makes them ideal for treating a subject with an HIV infection. Thus, disclosed are methods of treating and/or preventing HIV infection.
摘要翻译： 公开了单克隆中和抗体，其特异性结合HIV-1 gp41膜近端外部区域（MPER）。 还公开了包含特异性结合gp41的公开抗体，编码这些抗体的核酸，包含核酸的表达载体和表达核酸的分离的宿主细胞的组合物。 本文公开的抗体和组合物可用于检测生物样品中HIV-1的存在，或检测受试者中的HIV-1感染或诊断AIDS。 另外，所公开的抗体的广泛中和宽度使得它们理想地用于治疗HIV感染的受试者。 因此，公开了治疗和/或预防HIV感染的方法。
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