-
公开(公告)号：EP4225446A1
公开(公告)日：2023-08-16
申请号：EP21802867.8
申请日：2021-10-06
发明人： MCCARTNEY, Jason , ABELA, Alexander Russell , ABRAHAM, Sunny , ANDERSON, Corey Don , ARUMUGAM, Vijayalaksmi , CHAU, Jaclyn , CLEMENS, Jeremy , CLEVELAND, Thomas , DWIGHT, Timothy A. , FRIEMAN, Bryan A. , GROOTENHUIS, Peter , HADIDA RUAH, Sara Sabina , ISHIHARA, Yoshihiro , KRENITSKY, Paul , MILLER, Mark Thomas , PIERRE, Fabrice , SILINA, Alina , UY, Johnny , ZHOU, Jinglan
IPC分类号： A61P43/00 , C07D515/04 , A61K31/519
-
12.发明公开4 -OXO- 1H -QUINOLINE- 3 - CARBOXAMIDES AS MODULATORS OF ATP -BINDING CASSETTE TRANSPORTERS 审中-公开4-氧代喹啉1H 3 - 羧酰胺AS ATP结合盒转运体调节剂
公开(公告)号：EP2509954A1
公开(公告)日：2012-10-17
申请号：EP10793116.4
申请日：2010-12-10
发明人： SHETH, Urvi , FANNING, Lev, T.D. , NUMA, Mehdi , BINCH, Hayley , HURLEY, Dennis, James , ZHOU, Jinglan , HADIDA RUAH, Sara, S. , HAZLEWOOD, Anna, R. , SILINA, Alina , VAIRAGOUNDAR, Rajendran , VAN GOOR, Fredrick, F. , GROOTENHUIS, Peter, Diederik Jan , BOTFIELD, Martyn, C.
IPC分类号： C07D215/56 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/08 , A61K31/4709 , A61P11/00
CPC分类号： C07C215/76 , C07D209/08 , C07D209/14 , C07D209/18 , C07D209/42 , C07D209/94 , C07D213/20 , C07D213/73 , C07D215/227 , C07D215/38 , C07D215/56 , C07D217/06 , C07D223/16 , C07D265/36 , C07D279/16 , C07D311/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/10
摘要： The present invention relates to 4 -oxo- lH-quinoline- 3 carboxamides as modulators of ATP -Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present Invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
-
13.发明公开COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE 审中-公开ALS INHIBITOREN VON ATR-KINASE GEEIGNETE VERBINDUNGEN
公开(公告)号：EP2370424A1
公开(公告)日：2011-10-05
申请号：EP09756203.7
申请日：2009-11-10
发明人： CHARRIER, Jean-damien , DURRANT, Steven , KAY, David , O'DONNELL, Michael , KNEGTEL, Ronald , MACCORMICK, Somhairle , PINDER, Joanne , VIRANI, Anisa , YOUNG, Stephen , BINCH, Hayley , CLEVELAND, Thomas , FANNING, Lev, T.d. , HURLEY, Dennis , JOSHI, Pramod , SHETH, Urvi , SILINA, Alina , REAPER, Philip Michael
IPC分类号： C07D401/04 , C07D403/04 , C07D413/04 , A61K31/4965 , A61P35/00
CPC分类号： C07D403/14 , A61K31/497 , A61K31/541 , A61K31/551 , A61K45/06 , C07D241/28 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/113
摘要： The present disclosure relates to pyrazine compounds of formula (I) wherein L, n, R
1 , and R
2 are as described in the specification. These compounds are useful as inhibitors of ATR protein kinase. The disclosure also relates to pharmaceutically acceptable compositions comprising the compounds of the disclosure; methods of treating of various diseases, disorders, and conditions using the compounds of the disclosure; processes for preparing the compounds of the disclosure; intermediates for the preparation of the compounds of the disclosure; and methods of using the compounds in
in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.摘要翻译： 本公开涉及式I的吡嗪化合物：其中L，n，R 1和R 2如说明书中所述。 这些化合物可用作ATR蛋白激酶的抑制剂。 本公开还涉及包含本公开的化合物的药学上可接受的组合物; 使用本公开的化合物治疗各种疾病，病症和病症的方法; 制备本公开化合物的方法; 制备本公开化合物的中间体; 以及在体外应用中使用化合物的方法，例如研究激酶在生物学和病理学现象中的用途; 由这种激酶介导的细胞内信号转导途径的研究; 和新型激酶抑制剂的比较评估。
-
公开(公告)号：EP1973543A2
公开(公告)日：2008-10-01
申请号：EP06848092.0
申请日：2006-12-22
发明人： MAKINGS, Lewis, R. , GARCIA-GUZMAN BLANCO, Miguel , HURLEY, Dennis, J. , DRUTU, Ioana , RAFFAI, Gabriel , BERGERON, Daniele, M. , NAKATANI, Akiko , TERMIN, Andreas, P. , SILINA, Alina
IPC分类号： A61K31/435 , A61K31/438 , A61P43/00 , A61P25/00 , C07D471/00 , A61K31/4545 , A61K31/46 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , C07D471/10
CPC分类号： A61K31/4545 , A61K31/438 , A61K31/46 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , C07D221/20 , C07D401/04 , C07D401/06 , C07D405/04 , C07D417/14 , C07D471/10 , C07D487/08 , C07D491/10
摘要： The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
-
公开(公告)号：EP4335498A1
公开(公告)日：2024-03-13
申请号：EP23208747.8
申请日：2020-04-02
发明人： HADIDA RUAH, Sara Sabina , ISHIHARA, Yoshihiro , KRENITSKY, Paul , MCCARTNEY, Jason , MELILLO, Vito , MILLER, Mark Thomas , SILINA, Alina , UY, Johnny , ZHOU, Jinglan
IPC分类号： A61P11/00 , C07D239/69 , C07D515/08 , A61K31/395
摘要： Compound I, deuterated derivatives, and pharmaceutically acceptable salts of any of the foregoing are disclosed. Methods of treating cystic fibrosis using these compounds are also disclosed.
-
公开(公告)号：EP4225750A1
公开(公告)日：2023-08-16
申请号：EP21801755.6
申请日：2021-10-06
发明人： MCCARTNEY, Jason , ABRAHAM, Sunny , ANDERSON, Corey Don , ARUMUGAM, Vijayalaksmi , CHAU, Jaclyn , CLEVELAND, Thomas , DWIGHT, Timothy A. , FRIEMAN, Bryan A. , GROOTENHUIS, Peter , HADIDA RUAH, Sara Sabina , ISHIHARA, Yoshihiro , MILLER, Mark Thomas , SILINA, Alina , ZHOU, Jinglan
IPC分类号： C07D403/12 , C07D215/40 , C07D235/30 , C07D239/70 , C07D241/54 , C07D277/82 , C07D279/08 , C07D471/04 , C07D491/04 , C07D513/04 , A61P43/00 , A61K31/517 , A61K31/541 , A61K31/4375 , A61K31/4365
-
公开(公告)号：EP3946595A1
公开(公告)日：2022-02-09
申请号：EP20722087.2
申请日：2020-04-02
发明人： HADIDA RUAH, Sara Sabina , ISHIHARA, Yoshihiro , KRENITSKY, Paul , MCCARTNEY, Jason , MELILLO, Vito , MILLER, Mark Thomas , SILINA, Alina , UY, Johnny , ZHOU, Jinglan
IPC分类号： A61P11/00 , C07D239/69 , C07D515/08
-
18.发明公开MORPHOLINE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS 有权吗啉 - 螺环化合物哌啶甲酰胺ALS IONENKANALMODULATOREN
公开(公告)号：EP2686325A1
公开(公告)日：2014-01-22
申请号：EP12710841.3
申请日：2012-03-13
发明人： HADIDA-RUAH, Sara, Sabina , BINCH, Hayley, Marie , DENINNO, Michael, Paul , FANNING, Lev, Tyler Dewey , FRIEMAN, Bryan, A. , GROOTENHUIS, Peter, Diederik Jan , HILGRAF, Nicole , JOSHI, Pramod , KALLEL, Edward, Adam , PONTILLO, Joseph , SILINA, Alina , SHETH, Urvi, Jagdishbhai , HURLEY, Dennis, James , ARUMUGAM, Vijayalaksmi , MILLER, Mark, Thomas
IPC分类号： C07D498/10 , A61K31/424 , A61P29/00
CPC分类号： C07D498/10
摘要： The invention relates to morpholine spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
-
公开(公告)号：EP1987034B1
公开(公告)日：2011-07-20
申请号：EP07751501.3
申请日：2007-02-22
发明人： MAKINGS, Lewis, R. , GARCIA-GUZMAN BLANCO, Miguel , HURLEY, Dennis, J. , DRUTU, Ioana , RAFFAI, Gabriel , BERGERON, Daniele, M. , NAKATANI, Akiko , TERMIN, Andreas, P. , SILINA, Alina
IPC分类号： C07D471/10 , C07D519/00 , A61K31/438 , A61K31/46 , A61K31/4747 , A61P25/00
CPC分类号： C07D471/10
摘要： The present invention relates to modulators of muscarnic receptors of formula (I). The present invention also provides impositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
-
公开(公告)号：EP4225763A1
公开(公告)日：2023-08-16
申请号：EP21802089.9
申请日：2021-10-06
发明人： McCARTNEY, Jason , ABELA, Alexander Russell , ABRAHAM, Sunny , ANDERSON, Corey Don , ARUMUGAM, Vijayalaksmi , CHAU, Jaclyn , CLEMENS, Jeremy , CLEVELAND, Thomas , DWIGHT, Timothy A. , FRIEMAN, Bryan A. , GROOTENHUIS, Peter , HADIDA RUAH, Sara Sabina , ISHIHARA, Yoshihiro , MILLER, Mark Thomas , SILINA, Alina , ZHOU, Jinglan
IPC分类号： C07D515/04 , A61P43/00 , A61K31/519
-
-
-
-
-
-
-
-
-
搜索结果
28 条记录 (耗时 0.026 秒)
