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    NOVEL HETERODIMERIC PROTEINS
    12.
    发明公开
    NOVEL HETERODIMERIC PROTEINS 审中-公开

    公开(公告)号：EP3620473A1

    公开(公告)日：2020-03-11

    申请号：EP19187150.8

    申请日：2014-01-14

    申请人： Xencor, Inc.

    发明人： DESJARLAIS, John ,  MOORE, Gregory ,  RASHID, Rumana ,  BERNETT, Matthew J.

    IPC分类号： C07K16/46

    摘要： The invention provides novel heterodimeric proteins including heterodimeric antibodies. The present invention describes novel immunoglobulin compositions that simultaneously co-engage antigens, where both of the antigens are bound monovalently. The novel immunoglobulins described preferably utilize heterodimeric Fe regions. Methods of using the novel immunoglobulin compositions, particularly for therapeutic purposes, are also described herein.

    HETERODIMERIC PROTEINS
    19.
    发明公开
    HETERODIMERIC PROTEINS 审中-公开

    公开(公告)号：EP3936521A1

    公开(公告)日：2022-01-12

    申请号：EP21173787.9

    申请日：2014-03-17

    申请人： Xencor, Inc.

    发明人： MOORE, Gregory ,  DESJARLAIS, John ,  RASHID, Rumana ,  BERNETT, Matthew J.

    IPC分类号： C07K16/00 ,  C07K16/06 ,  C07K16/28 ,  C07K16/46

    摘要： In one aspect, the present invention provides heterodimeric antibodies comprising a first monomer comprising a first heavy chain constant domain comprising a first variant Fc domain and a first antigen binding domain and a second monomer comprising a second heavy chain constant domain comprising a second variant Fc domain and a second antigen binding domain. In an additional aspect the heterodimeric antibody comprises a first monomer comprising a heavy chain comprising a first Fc domain and a single chain Fv region (scFv) that binds a first antigen, wherein the scFv comprises a charged scFv linker. The heterodimeric antibody further comprises a second monomer comprising a first heavy chain comprising a second Fc domain and a first variable heavy chain and a first light chain.