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11.发明公开METHODS OF USING PNKP30, A MEMBER OF THE B7 FAMILY, TO MODULATE THE IMMUNE SYSTEM 审中-公开PROCEDURE FOR PNKP 30，对免疫系统的调制B7家族的一个成员中的应用
公开(公告)号：EP1891112A1
公开(公告)日：2008-02-27
申请号：EP06752531.1
申请日：2006-05-12
申请人： ZymoGenetics, Inc.
发明人： GAO, Zeren , LEVIN, Steven, D. , CLEGG, Christopher, H. , GROSS, Jane, A. , XU, Wenfeng , RAMSDELL, Frederick, J. , BRANDT, Cameron, S.
CPC分类号： C07K14/70532 , A61K38/00 , C07K2319/00 , C07K2319/21
摘要： Novel methods of using isolated polypeptides, isolated polynucleotides encoding the polypeptides, and related compositions are disclosed for pNKp30 protein. The methods involved modulating the proliferation of T-cells in vitro and in vivo and modulation of immune response. The present invention also includes methods for producing pNKp30, including soluble molecules, uses therefor and antibodies thereto.
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公开(公告)号：EP1576112A2
公开(公告)日：2005-09-21
申请号：EP03761891.5
申请日：2003-01-21
申请人： ZymoGenetics, Inc.
发明人： SPRECHER, Cindy, A. , GAO, Zeren , KUIJPER, Joseph, L. , DASOVICH, Maria, M. , GRANT, Francis, J. , PRESNELL, Scott, R. , WHITMORE, Theodore, E. , HAMMOND, Angela, K. , NOVAK, Julia, E. , GROSS, Jane, A. , DILLON, Stacey, R.
IPC分类号： C12N1/00
CPC分类号： C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要： There is provided an isolated multimeric or heterodimeric cytokine receptor comprising: a first polypeptide, wherein the first polypeptide comprises an amino acid sequence having at least 90 percent sequence identity with residues 20-732 of SEQ ID NO:111 or an amino acid sequence having at least 90 percent sequence identity with residues 20-649 of SEQ ID NO:109; and a second polypeptide comprising residues 28-429 of SEQ IDNO:7; wherein the multimeric or heterodimeric cytokine receptor binds a ligand comprising residues 27-164 of SEQ ID NO:2.
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公开(公告)号：EP1476541A2
公开(公告)日：2004-11-17
申请号：EP03729693.6
申请日：2003-01-21
申请人： ZymoGenetics, Inc.
发明人： SPRECHER, Cindy, A. , KUIJPER, Joseph, L. , DASOVICH, Maria, M. , GRANT, Francis, J. , HAMMOND, Angela, K. , NOVAK, Julia, E. , GROSS, Jane, A. , DILLON, Stacey, R.
IPC分类号： C12N5/10 , C12N15/19 , C12N15/62 , C12N15/63 , C07K14/52 , C07K16/24 , G01N33/53 , G01N33/567 , A61K38/19 , A61K39/395
CPC分类号： C07K16/24 , A01K2217/05 , A61K38/00 , C07K14/47 , C07K14/52 , C07K2317/24
摘要： The present invention relates to zcytor171ig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor171ig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
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公开(公告)号：EP1576112B1
公开(公告)日：2012-02-29
申请号：EP03761891.5
申请日：2003-01-21
申请人： ZymoGenetics, Inc.
发明人： SPRECHER, Cindy, A. , GAO, Zeren , KUIJPER, Joseph, L. , DASOVICH, Maria, M. , GRANT, Francis, J. , PRESNELL, Scott, R. , WHITMORE, Theodore, E. , HAMMOND, Angela, K. , NOVAK, Julia, E. , GROSS, Jane, A. , DILLON, Stacey, R.
IPC分类号： C07K14/715
CPC分类号： C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要： There is provided an isolated multimeric or heterodimeric cytokine receptor comprising: a first polypeptide, wherein the first polypeptide comprises an amino acid sequence having at least 90 percent sequence identity with residues 20-732 of SEQ ID NO:111 or an amino acid sequence having at least 90 percent sequence identity with residues 20-649 of SEQ ID NO:109; and a second polypeptide comprising residues 28-429 of SEQ IDNO:7; wherein the multimeric or heterodimeric cytokine receptor binds a ligand comprising residues 27-164 of SEQ ID NO:2.
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公开(公告)号：EP1407017B1
公开(公告)日：2009-06-03
申请号：EP01990899.5
申请日：2001-11-05
申请人： ZymoGenetics, Inc.
IPC分类号： C12N15/12 , C07K14/715 , C12N15/62 , C07K16/28
CPC分类号： C07K14/7151 , C07K2319/00 , C07K2319/30
摘要： Tumor necrosis factors and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human tumor necrosis factor receptor designated as 'Ztnfr 12'.
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公开(公告)号：EP1165791B1
公开(公告)日：2007-10-31
申请号：EP00916164.7
申请日：2000-03-09
申请人： ZymoGenetics, Inc.
发明人： NOVAK, Julie, E. , PRESNELL, Scott, R. , SPRECHER, Cindy, A. , FOSTER, Donald, C. , HOLLY, Richard, D. , GROSS, Jane, A. , JOHNSTON, Janet, V. , NELSON, Andrew, J. , DILLON, Stacey, R. , HAMMOND, Angela, K.
IPC分类号： C12N15/19 , C07K14/52 , C12N15/62 , C12N15/85 , C07K16/24 , C12Q1/68 , G01N33/68 , A61K38/19
CPC分类号： C07K14/52 , A61K38/00 , C07K2319/00 , C07K2319/55
摘要： The present invention relates to zalpha11 Ligand polynucleotide and polypeptide molecules. The zalpha11 Ligand is a novel cytokine. The polypeptides may be used within methods for stimulating the proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
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公开(公告)号：EP1141274B1
公开(公告)日：2003-09-10
申请号：EP00902354.0
申请日：2000-01-07
申请人： ZymoGenetics, Inc.
发明人： GROSS, Jane, A. , XU, Wenfeng , MADDEN, Karen , YEE, David, P.
IPC分类号： C12N15/11 , C07K14/705 , A61K38/17 , A61K39/395
CPC分类号： C07K14/70575 , A61K38/00 , C07K14/70578 , C07K16/2875 , C07K16/2878 , C07K2317/34 , C07K2317/76 , C07K2319/30
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公开(公告)号：EP1141274A2
公开(公告)日：2001-10-10
申请号：EP00902354.0
申请日：2000-01-07
申请人： ZymoGenetics, Inc.
发明人： GROSS, Jane, A. , XU, Wenfeng , MADDEN, Karen , YEE, David, P.
IPC分类号： C12N15/11 , C07K14/705 , A61K38/17 , A61K39/395
CPC分类号： C07K14/70575 , A61K38/00 , C07K14/70578 , C07K16/2875 , C07K16/2878 , C07K2317/34 , C07K2317/76 , C07K2319/30
摘要： Soluble, secreted tumor necrosis factor receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise one cysteine-rich repeat that is homologous to other tumor necrosis factor receptors, such as transmembrane activator and CAML-interactor (TACI). The polypeptides may be used for detecting ligands, agonists and antagonists. The polypeptides may also be used in methods that modulate B cell activation.
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