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公开(公告)号：EP0658200A1
公开(公告)日：1995-06-21
申请号：EP93920429.0
申请日：1993-08-30
申请人： ZYMOGENETICS, INC.
发明人： KINDSVOGLE, Wayne, R. , JELINEK, Laura, J. , SHEPPARD, Paul, O. , GRANT, Francis, J. , KUIJPER, Joseph, L. , FOSTER, Donald, C. , LOK, Si , O'HARA, Patrick, J.
CPC分类号： C07K14/723 , A61K38/00 , C07K14/72 , C07K2319/00 , C07K2319/02 , C12Q1/66 , G01N33/74 , G01N2333/605 , G01N2333/72
摘要： The present invention provides isolated DNA molecules comprising a DNA segment encoding a glucagon receptor. Also provided are DNA constructs comprising a first DNA segment encoding a glucagon receptor operably linked to additional DNA segments required for the expression of the first DNA segment, as well as host cells containing such DNA constructs. The present invention also provides amethod for detecting the presence of glucagon antagonists, comprising the steps of (a) exposing a compound in the presence of a glucagon agonist to a recombinant glucagon receptor coupled to a response pathway under conditions and for time sufficient to allow binding of the compound to the receptor and an associated response through the pathway, and (b) detecting a reduction in the stimulation of the response pathway resulting from the binding of the compound to the glucagon receptor, relative to the stimulation of the response pathway by the glucagon agonist alone and therefrom determining the presence of a glucagon antagonist.
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公开(公告)号：EP1576112A3
公开(公告)日：2005-10-26
申请号：EP03761891.5
申请日：2003-01-21
申请人： ZymoGenetics, Inc.
发明人： SPRECHER, Cindy, A. , GAO, Zeren , KUIJPER, Joseph, L. , DASOVICH, Maria, M. , GRANT, Francis, J. , PRESNELL, Scott, R. , WHITMORE, Theodore, E. , HAMMOND, Angela, K. , NOVAK, Julia, E. , GROSS, Jane, A. , DILLON, Stacey, R.
IPC分类号： C12N1/00
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公开(公告)号：EP0917469A1
公开(公告)日：1999-05-26
申请号：EP97922438.0
申请日：1997-04-18
CPC分类号： C12N5/0654 , A61K35/12 , A61K38/2264 , C12N2501/355 , C12N2502/076
摘要： Methods for inducing bone formation using ob protein are disclosed. The methods can be used for treating osteoporosis, repairing fractures, dental defects, resectioning due to oncogenesis and elongation of the growth plate/long bone. In addition, the methods can be used for ex vivo therapy and reinfused into a mammal.
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公开(公告)号：EP1325115B1
公开(公告)日：2016-07-27
申请号：EP01952259.8
申请日：2001-06-26
申请人： ZymoGenetics, Inc.
发明人： SPRECHER, Cindy, A. , PRESNELL, Scott, R. , GAO, Zeren , WHITMORE, Theodore, E. , KUIJPER, Joseph, L. , MAURER, Mark, F.
IPC分类号： C12N15/00 , C07K14/715
CPC分类号： C07K14/715
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公开(公告)号：EP1576112B1
公开(公告)日：2012-02-29
申请号：EP03761891.5
申请日：2003-01-21
申请人： ZymoGenetics, Inc.
发明人： SPRECHER, Cindy, A. , GAO, Zeren , KUIJPER, Joseph, L. , DASOVICH, Maria, M. , GRANT, Francis, J. , PRESNELL, Scott, R. , WHITMORE, Theodore, E. , HAMMOND, Angela, K. , NOVAK, Julia, E. , GROSS, Jane, A. , DILLON, Stacey, R.
IPC分类号： C07K14/715
CPC分类号： C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要： There is provided an isolated multimeric or heterodimeric cytokine receptor comprising: a first polypeptide, wherein the first polypeptide comprises an amino acid sequence having at least 90 percent sequence identity with residues 20-732 of SEQ ID NO:111 or an amino acid sequence having at least 90 percent sequence identity with residues 20-649 of SEQ ID NO:109; and a second polypeptide comprising residues 28-429 of SEQ IDNO:7; wherein the multimeric or heterodimeric cytokine receptor binds a ligand comprising residues 27-164 of SEQ ID NO:2.
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公开(公告)号：EP1476541B1
公开(公告)日：2008-07-16
申请号：EP03729693.6
申请日：2003-01-21
申请人： ZymoGenetics, Inc.
发明人： SPRECHER, Cindy A. , KUIJPER, Joseph, L. , DASOVICH, Maria M. , GRANT, Francis, J. , HAMMOND, Angela K. , NOVAK, Julia, E. , GROSS, Jane A. , DILLON, Stacey, R.
IPC分类号： C12N5/10 , C12N15/19 , C12N15/62 , C12N15/63 , C07K14/52 , C07K16/24 , G01N33/53 , G01N33/567 , A61K38/19 , A61K39/395 , C07K14/54
CPC分类号： C07K16/24 , A01K2217/05 , A61K38/00 , C07K14/47 , C07K14/52 , C07K2317/24
摘要： The present invention relates to zcytor171ig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor171ig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
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公开(公告)号：EP1931708A1
公开(公告)日：2008-06-18
申请号：EP06817108.1
申请日：2006-10-18
申请人： Zymogenetics, Inc.
发明人： GAO, Zeren, , KUESTNER, Rolf, E. , APPLEBY, Mark, W. , LEWIS, Katherine, E. , MCKERNAN, Patricia, A. , OKADA, Shannon, L. , TAFT, David, W. , KUIJPER, Joseph, L. , JASPERS, Stephen, R. , LEVIN, Steven, D.
IPC分类号： C07K14/715 , C12N15/62 , C12N15/12 , A61K38/17
CPC分类号： C07K14/7155 , A61K38/00 , C07K2319/20 , C07K2319/21 , C07K2319/30
摘要： The present invention relates IL-17RE antagonists, such as soluble receptors and anti-IL-17RE antibodies, that are useful in blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17C. IL-17C is a cytokine that is involved in inflammatory processes and human disease. IL-17RE is a receptor for IL-17C. The present invention includes soluble IL-17RE, anti-IL-17RE antibodies and binding partners, as well as methods for antagonizing IL-17C using such soluble receptors, antibodies and binding partners.
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8.发明公开SOLUBLE ZCYTOR21, ANTI-ZCYTOR21 ANTIBODIES AND BINDING PARTNERS AND METHODS OF USING IN INFLAMMATION 审中-公开可溶性ZCYTOR21，抗ZCYTOR21抗体和结合在炎症的方法为合作伙伴和使用他们的
公开(公告)号：EP1802657A2
公开(公告)日：2007-07-04
申请号：EP05818898.8
申请日：2005-10-18
申请人： ZymoGenetics, Inc.
发明人： GAO, Zeren , KUESTNER, Rolf, E. , APPLEBY, Mark, W. , LEWIS, Katherine, E. , MCKERNAN, Patricia, A. , OKADA, Shannon, L. , TAFT, David, W. , KUIJPER, Joseph, L. , JASPERS, Stephen, R. , LEVIN, Steven, D.
IPC分类号： C07K14/715
CPC分类号： C07K14/7155 , A61K38/00 , A61K39/395 , A61K47/50 , A61K47/60 , C07K14/54 , C07K16/00
摘要： The present invention relates ZcytoR21 antagonists, such as soluble receptors and anti-ZcytoR21 antibodies, that are useful in blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17C. IL-17C is a cytokine that is involved in inflammatory processes and human disease. ZcytoR21 is a receptor for IL-17C. The present invention includes soluble ZcytoR21, anti-ZcytoR21 antibodies and binding partners, as well as methods for antagonizing IL-17C using such soluble receptors, antibodies and binding partners.
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公开(公告)号：EP1576112A2
公开(公告)日：2005-09-21
申请号：EP03761891.5
申请日：2003-01-21
申请人： ZymoGenetics, Inc.
发明人： SPRECHER, Cindy, A. , GAO, Zeren , KUIJPER, Joseph, L. , DASOVICH, Maria, M. , GRANT, Francis, J. , PRESNELL, Scott, R. , WHITMORE, Theodore, E. , HAMMOND, Angela, K. , NOVAK, Julia, E. , GROSS, Jane, A. , DILLON, Stacey, R.
IPC分类号： C12N1/00
CPC分类号： C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要： There is provided an isolated multimeric or heterodimeric cytokine receptor comprising: a first polypeptide, wherein the first polypeptide comprises an amino acid sequence having at least 90 percent sequence identity with residues 20-732 of SEQ ID NO:111 or an amino acid sequence having at least 90 percent sequence identity with residues 20-649 of SEQ ID NO:109; and a second polypeptide comprising residues 28-429 of SEQ IDNO:7; wherein the multimeric or heterodimeric cytokine receptor binds a ligand comprising residues 27-164 of SEQ ID NO:2.
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公开(公告)号：EP1556084A2
公开(公告)日：2005-07-27
申请号：EP03774639.3
申请日：2003-10-06
申请人： ZymoGenetics, Inc.
发明人： JASPERS, Stephen, R. , SHEPPARD, Paul, O. , BISHOP, Paul, D. , KUIJPER, Joseph, L. , DEISHER, Theresa, A.
IPC分类号： A61K39/40
CPC分类号： C07K14/72 , A61K38/00 , A61K47/6811 , C07K14/575 , C07K14/63 , C07K16/18
摘要： The present invention relates to a method of regulating body weight, body mass, fat depositions, and circulating glucose levels, by antagonizing zsig33 peptide by binding it with an antibody.
摘要翻译： 本发明涉及通过将zsig33肽与抗体结合来拮抗zsig33肽来调节体重，体重，脂肪沉积和循环葡萄糖水平的方法。
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