公开(公告)号：EP1576112A3

公开(公告)日：2005-10-26

申请号：EP03761891.5

申请日：2003-01-21

申请人： ZymoGenetics, Inc.

发明人： SPRECHER, Cindy, A. ,  GAO, Zeren ,  KUIJPER, Joseph, L. ,  DASOVICH, Maria, M. ,  GRANT, Francis, J. ,  PRESNELL, Scott, R. ,  WHITMORE, Theodore, E. ,  HAMMOND, Angela, K. ,  NOVAK, Julia, E. ,  GROSS, Jane, A. ,  DILLON, Stacey, R.

IPC分类号： C12N1/00

公开(公告)号：EP1228211A2

公开(公告)日：2002-08-07

申请号：EP00980335.4

申请日：2000-11-09

申请人： ZymoGenetics, Inc.

发明人： HOLLOWAY, James, L. ,  GAO, Zeren ,  WHITMORE, Theodore, E.

IPC分类号： C12N15/12 ,  C07K14/47 ,  C07K16/18 ,  C12Q1/68 ,  G01N33/574 ,  A01K67/027

CPC分类号： C07K14/4702

摘要： The present invention relates to polynucleotide and polypeptide molecules for zmse1, a novel human CRIB protein. The polypeptides, and polynucleotides encoding them, may be used for detecting human chromosomal abnormalities and cancers. The present invention also includes antibodies to the zmse1 polypeptides.

摘要翻译： 本发明涉及新型人CRIB蛋白zmse1的多核苷酸和多肽分子。 多肽和编码它们的多核苷酸可用于检测人类染色体异常和癌症。 本发明还包括zmse1多肽的抗体。

公开(公告)号：EP1497415A2

公开(公告)日：2005-01-19

申请号：EP03721762.7

申请日：2003-04-18

申请人： ZymoGenetics, Inc.

发明人： PRESNELL, Scott, R. ,  XU, Wenfeng ,  NOVAK, Julia, E. ,  WHITMORE, Theodore, E. ,  GRANT, Francis, J. ,  KINDSVOGEL, Wayne, R. ,  KLUCHER, Kevin, M.

IPC分类号： C12N9/00 ,  C12N15/00 ,  C12N15/63 ,  C12N15/85 ,  C07H21/04 ,  C07K17/00

CPC分类号： C07K14/7155

摘要： Novel methods are disclosed for forming a heterodimeric receptor complex with IL-28r AND CRF2-4. The methods may be used for detecting and treating viral infections in in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

公开(公告)号：EP0977861B1

公开(公告)日：2004-06-23

申请号：EP98918640.8

申请日：1998-04-23

申请人： ZymoGenetics, Inc.

发明人： PRESNELL, Scott, R. ,  GILBERT, Teresa ,  WHITMORE, Theodore, E. ,  FOSTER, Donald, C. ,  HART, Charles, E. ,  LEHNER, Joyce, M. ,  MARTINEZ, Theresa ,  HOFFMANN, Ross, C.

IPC分类号： C12N15/19 ,  C07K14/52 ,  C12N15/62 ,  C07K19/00 ,  C07K16/24 ,  C07K16/42 ,  C12Q1/66 ,  C12Q1/68 ,  G01N33/52 ,  G01N33/60

CPC分类号： C07K14/52 ,  C07K2319/00 ,  C07K2319/02

摘要： Novel mammalian zcyto7 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies.

公开(公告)号：EP1009825A1

公开(公告)日：2000-06-21

申请号：EP98911383.2

申请日：1998-02-18

申请人： ZymoGenetics, Inc.

发明人： LOK, Si ,  KHO, Choon, J. ,  JELMBERG, Anna, C. ,  ADAMS, Robyn, L. ,  WHITMORE, Theodore, E. ,  FARRAH, Theresa, M.

IPC分类号： C12N15/12 ,  C07K14/715 ,  C12N15/62 ,  C07K16/28 ,  C07K16/42 ,  C07K19/00 ,  G01N33/50

CPC分类号： C07K14/715 ,  C07K2319/02 ,  Y10S930/12 ,  Y10S930/14

摘要： Novel cytokine receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in kidneys, pancreas, prostate, adrenal cortex and nervous tissue. The polypeptides may be used within methods for detecting ligands that promote the proliferation and/or differentiation of these organs.

公开(公告)号：EP0977861A1

公开(公告)日：2000-02-09

申请号：EP98918640.8

申请日：1998-04-23

申请人： ZymoGenetics, Inc.

发明人： PRESNELL, Scott, R. ,  GILBERT, Teresa ,  WHITMORE, Theodore, E. ,  FOSTER, Donald, C. ,  HART, Charles, E. ,  LEHNER, Joyce, M. ,  MARTINEZ, Theresa ,  HOFFMANN, Ross, C.

IPC分类号： C12N15/19 ,  C07K14/52 ,  C12N15/62 ,  C07K19/00 ,  C07K16/24 ,  C07K16/42 ,  C12Q1/66 ,  C12Q1/68 ,  G01N33/52 ,  G01N33/60

CPC分类号： C07K14/52 ,  C07K2319/00 ,  C07K2319/02

摘要： Novel mammalian zcyto7 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies.

公开(公告)号：EP1325115B1

公开(公告)日：2016-07-27

申请号：EP01952259.8

申请日：2001-06-26

申请人： ZymoGenetics, Inc.

发明人： SPRECHER, Cindy, A. ,  PRESNELL, Scott, R. ,  GAO, Zeren ,  WHITMORE, Theodore, E. ,  KUIJPER, Joseph, L. ,  MAURER, Mark, F.

IPC分类号： C12N15/00 ,  C07K14/715

CPC分类号： C07K14/715

公开(公告)号：EP1576112B1

公开(公告)日：2012-02-29

申请号：EP03761891.5

申请日：2003-01-21

申请人： ZymoGenetics, Inc.

发明人： SPRECHER, Cindy, A. ,  GAO, Zeren ,  KUIJPER, Joseph, L. ,  DASOVICH, Maria, M. ,  GRANT, Francis, J. ,  PRESNELL, Scott, R. ,  WHITMORE, Theodore, E. ,  HAMMOND, Angela, K. ,  NOVAK, Julia, E. ,  GROSS, Jane, A. ,  DILLON, Stacey, R.

IPC分类号： C07K14/715

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： There is provided an isolated multimeric or heterodimeric cytokine receptor comprising: a first polypeptide, wherein the first polypeptide comprises an amino acid sequence having at least 90 percent sequence identity with residues 20-732 of SEQ ID NO:111 or an amino acid sequence having at least 90 percent sequence identity with residues 20-649 of SEQ ID NO:109; and a second polypeptide comprising residues 28-429 of SEQ IDNO:7; wherein the multimeric or heterodimeric cytokine receptor binds a ligand comprising residues 27-164 of SEQ ID NO:2.

公开(公告)号：EP1230362A2

公开(公告)日：2002-08-14

申请号：EP00978641.9

申请日：2000-11-14

申请人： ZymoGenetics, Inc.

发明人： SHEPPARD, Paul, O. ,  BISHOP, Paul, D. ,  WHITMORE, Theodore, E. ,  THOMPSON, Penny, P.

IPC分类号： C12N15/12 ,  C07K14/47 ,  C07K16/18 ,  C12Q1/68 ,  G01N33/53 ,  C12N15/62

CPC分类号： C07K14/4702 ,  A61K38/00 ,  C07K2319/00

摘要： The present invention provides two members of a new family of human proteins, designated as 'Zven.' The Zvenl gene, which resides in human chromosome 3p21.1 - 3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes.

公开(公告)号：EP1576112A2

公开(公告)日：2005-09-21

申请号：EP03761891.5

申请日：2003-01-21

申请人： ZymoGenetics, Inc.

发明人： SPRECHER, Cindy, A. ,  GAO, Zeren ,  KUIJPER, Joseph, L. ,  DASOVICH, Maria, M. ,  GRANT, Francis, J. ,  PRESNELL, Scott, R. ,  WHITMORE, Theodore, E. ,  HAMMOND, Angela, K. ,  NOVAK, Julia, E. ,  GROSS, Jane, A. ,  DILLON, Stacey, R.

IPC分类号： C12N1/00

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： There is provided an isolated multimeric or heterodimeric cytokine receptor comprising: a first polypeptide, wherein the first polypeptide comprises an amino acid sequence having at least 90 percent sequence identity with residues 20-732 of SEQ ID NO:111 or an amino acid sequence having at least 90 percent sequence identity with residues 20-649 of SEQ ID NO:109; and a second polypeptide comprising residues 28-429 of SEQ IDNO:7; wherein the multimeric or heterodimeric cytokine receptor binds a ligand comprising residues 27-164 of SEQ ID NO:2.