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11.发明授权SUBSTITUTED HETEROCYCLES, THEIR USE AS MEDICAMENT, AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM 有权取代的杂环，及其作为药物的用途和药物制剂含有它们的
公开(公告)号：EP1896416B1
公开(公告)日：2008-10-15
申请号：EP06754277.9
申请日：2006-06-10
申请人： sanofi-aventis
发明人： BRENDEL, Joachim , ENGLERT, Heinrich, Christian , WIRTH, Klaus , WAGNER, Michael , RUXER, Jean-Marie c/o Aventis Pharma , PILORGE, Fabienne c/o Aventis Pharma
IPC分类号： C07D213/64 , C07D237/14 , A61K31/4412 , A61K31/50 , A61P9/00 , A61P11/00 , A61P25/00 , A61P35/00
CPC分类号： C07D213/64 , C07D237/14
摘要： The invention relates to compounds of the formula (I), in which R1 , R2, R3, R4, R5, R6 and X have the meanings stated in the claims. The compounds are particularly suitable as antiarrhythmic active ingredients, in particular for the treatment and prophylaxis of atrial arrhythmias, for example atrial fibrillation (AF) or atrial flutter.
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12.发明公开KOMBINATION VON PHENYLCARBONSÄUREAMIDEN MIT BETA-ADRENOZEPTOREN-BLOCKERN UND DEREN VERWENDUNG ZUR BEHANDLUNG VON VORHOFARRHYTHMIEN 审中-公开与β-肾上腺素能受体阻滞剂phenylcarboxamides组合及其用于治疗房性心律失常的使用
公开(公告)号：EP1670551A1
公开(公告)日：2006-06-21
申请号：EP04764792.0
申请日：2004-09-03
发明人： WIRTH, Klaus , BRENDEL, Joachim , GOEGELEIN, Heinz
CPC分类号： A61K31/18 , A61K31/00 , A61K31/138 , A61K31/165 , A61K31/44 , A61K31/47 , A61K45/06 , A61K2300/00
摘要： The invention relates to the combination of one or more β-blockers and one or more Kv1.5 blockers, in particular phenylcarboxamides of formula (la) and/or (lb) and/or pharmaceutically-acceptable salts thereof and the use of said combination for the treatment of atrial arrhythmias.
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13.发明授权KOMBINATION VON PHENYLCARBONSÄUREAMIDEN MIT BLOCKERN DES IKR-KANALS UND DEREN VERWENDUNG ZUR BEHANDLUNG VON VORHOFARRHYTHMIEN 有权phenylcarboxamides与受体阻滞剂的IR通道与它们用于房性心律失常疗法相结合
公开(公告)号：EP1605976B1
公开(公告)日：2010-02-24
申请号：EP04717614.4
申请日：2004-03-05
发明人： BRENDEL, Joachim , WIRTH, Klaus , GOEGELEIN, Heinz , ALLESSIE, Maurits, Department of Physiology , BLAAUW, Yuri, Department of Physiology
IPC分类号： A61K31/4406 , A61K31/18 , A61P9/06
CPC分类号： A61K31/18 , A61K31/165 , A61K31/44 , A61K45/06 , A61K2300/00
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14.发明公开SUBSTITUTED ISOQUINOLINE AND ISOQUINOLINONE DERIVATIVES AS INHIBITORS OF RHO-KINASE 有权取代的异喹啉和ISOCHINOLINONDERIVATE AS RHO激酶抑制剂
公开(公告)号：EP2102187A1
公开(公告)日：2009-09-23
申请号：EP07856886.2
申请日：2007-12-19
申请人： Sanofi-Aventis
IPC分类号： C07D401/12 , C07D401/14 , A61P9/12 , A61P11/00 , A61K31/4725
CPC分类号： C07D401/12 , C07D401/14
摘要： The invention relates to 6-substituted isoquinoline and isochinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
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15.发明授权2'-SUBSTITUIERTE 1,1'-BIPHENYL-2-CARBOXAMIDE, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS MEDIKAMENT SOWIE SIE ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN 有权2'-取代-1,1'-联苯-2-羧酰胺，PROCESS FOR THEIR，及其作为药物的用途和含有药物制剂
公开(公告)号：EP1222163B1
公开(公告)日：2006-07-12
申请号：EP00967703.0
申请日：2000-09-19
IPC分类号： C07C271/22 , C07D213/40 , C07C311/19 , C07C311/06 , C07C311/13 , C07C233/11 , C07C233/87 , C07C235/38 , C07C275/28 , C07C275/24 , C07C335/16 , C07C335/12 , C07D233/54 , A61K31/165 , A61P9/06
CPC分类号： C07D213/40 , C07C237/42 , C07C271/22 , C07C271/54 , C07C275/42 , C07C311/06 , C07C311/13 , C07C311/19 , C07C311/29 , C07C311/46 , C07C311/47 , C07C317/18 , C07C335/16 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D233/54
摘要： The invention relates to compounds of formula (I), wherein R(1), R(2), R(3), R(4), R(5), R(6), R(7), R(8), R(30) and R(31) have the meanings cited in the Claims and are especially suitable as novel antiarrhythmic active agents, in particular for the treatment and prophylaxis of atrial arrhythmia, e.g. atrial fibrillations (AF) or atrial flutter.
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16.发明公开2-(BUTYL-1-SULFONYLAMINO)-N- 1(R)-(6-METHOXY-PYRIDIN-3-YL)-PROPYL -BENZAMID, DESSEN VERWENDUNG ALS MEDIKAMENT SOWIE DIESES ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN 审中-公开2-（丁基-1-磺酰基氨基）-N- 1（R） - （6-甲氧基 - 吡啶-3-基） - 丙基 - 苯甲酰胺，及其用作药物和含有药物制剂
公开(公告)号：EP1606237A1
公开(公告)日：2005-12-21
申请号：EP04717628.4
申请日：2004-03-05
IPC分类号： C07C11/08 , C07D213/64 , A61K31/18 , A61P9/06
CPC分类号： C07D213/64
摘要： The invention relates to 2-(Butyl-1-sulfonylamino)-N-[1 (R)-(6-methoxy-pyridin-3-yl)-propyl]-benzamid of formula (I), and to the pharmaceutically acceptable salts thereof. Said invention also relates to the production and use of the inventive compound or the pharmaceutically acceptable salts thereof, in particular for treating and preventing auricular arrhythmia, for example auricular fibrillation (atrial fibrillation) or auricular flutter (atrial flutter).
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17.发明公开KOMBINATION VON PHENYLCARBONSÄUREAMIDEN MIT BLOCKERN DES IKR-KANALS UND DEREN VERWENDUNG ZUR BEHANDLUNG VON VORHOFARRHYTHMIEN 有权phenylcarboxamides与受体阻滞剂的IR通道与它们用于房性心律失常疗法相结合
公开(公告)号：EP1605976A1
公开(公告)日：2005-12-21
申请号：EP04717614.4
申请日：2004-03-05
发明人： BRENDEL, Joachim , WIRTH, Klaus , GOEGELEIN, Heinz , ALLESSIE, Maurits,Department of Physiology , BLAAUW, Yuri,Department of Physiology
CPC分类号： A61K31/18 , A61K31/165 , A61K31/44 , A61K45/06 , A61K2300/00
摘要： The invention relates to a combination of one or several IKr channel inhibitors and one or several Kv1.5 inhibitors, in particular phenylcarboxyl acid amides represented by the formula (Ia) and/or (Ib), and/or acceptable pharmaceutical salts thereof and to the use of the inventive combination for treating atrial arrhythmia.
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