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1.发明授权
公开(公告)号：EP1664058B1
公开(公告)日：2007-11-14
申请号：EP04764791.2
申请日：2004-09-03
发明人： LANG, Hans-Jochen , HEINELT, Uwe , WIRTH, Klaus , LICHER, Thomas
IPC分类号： C07D495/04 , A61K31/4188 , A61P1/00 , A61P11/00
CPC分类号： C07D495/04
摘要： The invention relates to substituted thienoimidazoles of formula (I) or (II), where R1 to R4 have the meanings given in the claims. Medicaments comprising compounds of this type are useful for the prevention or treatment of diverse diseases. The compounds find application, amongst other things, for the treatment of breathing disorders and snoring, to improve the breathing process, for treatment of chronic and acute diseases of the kidney and the intestine, diseases caused by ischaemic and/or reperfusion events, proliferative or fibrotic diseases, for the treatment or prophylaxis of diseases of the central nervous system, lipometabolism, diabetes, blood clotting and parasitic attack.
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2.发明公开
公开(公告)号：EP1664058A1
公开(公告)日：2006-06-07
申请号：EP04764791.2
申请日：2004-09-03
发明人： LANG, Hans-Jochen , HEINELT, Uwe , WIRTH, Klaus , LICHER, Thomas
IPC分类号： C07D495/04 , A61K31/4188 , A61P1/00 , A61P11/00
CPC分类号： C07D495/04
摘要： The invention relates to substituted thienoimidazoles of formula (I) or (II), where R1 to R4 have the meanings given in the claims. Medicaments comprising compounds of this type are useful for the prevention or treatment of diverse diseases. The compounds find application, amongst other things, for the treatment of breathing disorders and snoring, to improve the breathing process, for treatment of chronic and acute diseases of the kidney and the intestine, diseases caused by ischaemic and/or reperfusion events, proliferative or fibrotic diseases, for the treatment or prophylaxis of diseases of the central nervous system, lipometabolism, diabetes, blood clotting and parasitic attack.
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3.发明授权KOMBINATION VON PHENYLCARBONSÄUREAMIDEN MIT BLOCKERN DES IKR-KANALS UND DEREN VERWENDUNG ZUR BEHANDLUNG VON VORHOFARRHYTHMIEN 有权phenylcarboxamides与受体阻滞剂的IR通道与它们用于房性心律失常疗法相结合
公开(公告)号：EP1605976B1
公开(公告)日：2010-02-24
申请号：EP04717614.4
申请日：2004-03-05
发明人： BRENDEL, Joachim , WIRTH, Klaus , GOEGELEIN, Heinz , ALLESSIE, Maurits, Department of Physiology , BLAAUW, Yuri, Department of Physiology
IPC分类号： A61K31/4406 , A61K31/18 , A61P9/06
CPC分类号： A61K31/18 , A61K31/165 , A61K31/44 , A61K45/06 , A61K2300/00
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4.发明公开KV1.5-BLOCKER ZUR SELEKTIVEN STEIGERUNG DER VORHOFKONTRAKTILITÄT UND BEHANDLUNG DER HERZINSUFFIZIENZ 审中-公开对Kv1.5阻滞剂FOR THE选择性增加心房收缩力和治疗心力衰竭
公开(公告)号：EP1720549A1
公开(公告)日：2006-11-15
申请号：EP05707351.2
申请日：2005-02-12
发明人： WIRTH, Klaus
IPC分类号： A61K31/4406 , A61K31/166 , A61K31/44 , A61P9/04
CPC分类号： A61K31/4406 , A61K31/166 , A61K31/44
摘要： The invention relates to the contractility-increasing action of Kvl.5-blockers, especially phenylcarboxylic acid amides of formulae la and/or lb (I), (II) and/or pharmaceutically acceptable salts thereof, for treating reduced atrial contractility and cardiac insufficiency, especially cardiac insufficiency caused by diastolic dysfunction.
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5.发明授权
公开(公告)号：EP1255724B1
公开(公告)日：2006-08-30
申请号：EP00977604.8
申请日：2000-12-01
发明人： HEINELT, Uwe , LANG, Hans-Jochen , KLEEMANN, Heinz-Werner , SCHWARK, Jan-Robert , WIRTH, Klaus , JANSEN, Hans-Willi
IPC分类号： C07C211/38 , C07C217/56 , A61K31/137
CPC分类号： C07C317/32 , C07B2200/07 , C07C211/38 , C07C211/49 , C07C215/30 , C07C217/58 , C07C217/60 , C07C217/62 , C07C229/38 , C07C237/30 , C07C255/58 , C07C257/18 , C07C311/37 , C07C323/32 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/68
摘要： The invention relates to substituted norbornylamino derivatives containing exo-configured nitrogen and an endo-annellated pentacyclic ring of formula (I) and exo-configured nitrogen and an exo-annellated pentacyclic ring of formula (Ia), wherein R1, R2 R3, R4, R5, A, B, S1 and S2 have the meanings cited in the claims. Said derivatives are especially suitable as anti-hypertensive agents for reducing or preventing ischaemia-induced damage, as medicaments for use in surgical procedures for treating ischaemias of the nervous system, of a cerebrovascular accident and of a cerebral oedema. The derivatives are also suitable for treating shock, an impaired respiratory impulse, snoring, or for use as a laxative, as an agent against ectoparasites, in the prophylaxis of gall stones, as an anti-atherosclerotic agent, as an agent for treating late complications of diabetes, or for treating cancerous illnesses, fibrotic disorders, endothelial dysfunction and organ hypertrophies and hyperplasias. Said derivatives act as inhibitors of the cellular sodium-proton-antiporter. They also influence serum lipoproteins and can thus be used in the prophylaxis and reversal of atherosclerotic changes.
摘要翻译： 应用程序盘松动substituiertem降冰片衍生物，它们的制备方法，它们作为药物或诊断和药物，其包含具有外切构造氮气下式的内切稠合的五元环的和themSubstituted降冰片衍生物使用I，或具有外切构造氮 和下式的外切稠合的五元环的我泉其中R1，R2，R3，R4，R5，A，B，S1和S2是如在权利要求限定，是高度适合用作抗高血压剂，用于 减少或防止缺血性损伤，用作药物，用于神经系统的缺血的治疗外科手术中风和脑水肿，休克，受损的呼吸驱动的，对于打鼾的治疗，作为泻药，作为对抗剂 体外寄生虫，为防止形成胆结石，因为antiatherosclerotics的，因为对后期糖尿病并发症，癌性疾病，纤维变性疾病，药物恩 内皮功能障碍，和器官hypertrophies和hyperplasias.They是蜂窝钠/质子反向转运蛋白的抑制剂。 他们必须对血清脂蛋白的影响，可以为动脉粥样硬化的变化预防和回归了。所以使用。
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6.发明公开2-(BUTYL-1-SULFONYLAMINO)-N- 1(R)-(6-METHOXY-PYRIDIN-3-YL)-PROPYL -BENZAMID, DESSEN VERWENDUNG ALS MEDIKAMENT SOWIE DIESES ENTHALTENDE PHARMAZEUTISCHE ZUBEREITUNGEN 审中-公开2-（丁基-1-磺酰基氨基）-N- 1（R） - （6-甲氧基 - 吡啶-3-基） - 丙基 - 苯甲酰胺，及其用作药物和含有药物制剂
公开(公告)号：EP1606237A1
公开(公告)日：2005-12-21
申请号：EP04717628.4
申请日：2004-03-05
IPC分类号： C07C11/08 , C07D213/64 , A61K31/18 , A61P9/06
CPC分类号： C07D213/64
摘要： The invention relates to 2-(Butyl-1-sulfonylamino)-N-[1 (R)-(6-methoxy-pyridin-3-yl)-propyl]-benzamid of formula (I), and to the pharmaceutically acceptable salts thereof. Said invention also relates to the production and use of the inventive compound or the pharmaceutically acceptable salts thereof, in particular for treating and preventing auricular arrhythmia, for example auricular fibrillation (atrial fibrillation) or auricular flutter (atrial flutter).
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7.发明公开KOMBINATION VON PHENYLCARBONSÄUREAMIDEN MIT BLOCKERN DES IKR-KANALS UND DEREN VERWENDUNG ZUR BEHANDLUNG VON VORHOFARRHYTHMIEN 有权phenylcarboxamides与受体阻滞剂的IR通道与它们用于房性心律失常疗法相结合
公开(公告)号：EP1605976A1
公开(公告)日：2005-12-21
申请号：EP04717614.4
申请日：2004-03-05
发明人： BRENDEL, Joachim , WIRTH, Klaus , GOEGELEIN, Heinz , ALLESSIE, Maurits,Department of Physiology , BLAAUW, Yuri,Department of Physiology
CPC分类号： A61K31/18 , A61K31/165 , A61K31/44 , A61K45/06 , A61K2300/00
摘要： The invention relates to a combination of one or several IKr channel inhibitors and one or several Kv1.5 inhibitors, in particular phenylcarboxyl acid amides represented by the formula (Ia) and/or (Ib), and/or acceptable pharmaceutical salts thereof and to the use of the inventive combination for treating atrial arrhythmia.
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8.发明公开
公开(公告)号：EP1592669A2
公开(公告)日：2005-11-09
申请号：EP04703371.7
申请日：2004-01-20
IPC分类号： C07D233/50 , C07D235/30 , A61K31/4168 , A61K31/4184 , A61P1/10 , A61P9/12 , A61P11/16 , A61P13/12 , A61P33/02 , A61P39/00
CPC分类号： C07D233/50
摘要： The invention relates to compounds of formula (I) whose radicals R1-R8 are defined as in the claims. Compounds of this type are useful in the prevention or treatment of diverse disorders. They can be used, among other things, in the treatment of: kidney diseases such as acute or chronic kidney failure; failures in biliary function; breathing disturbances such as snoring or sleep apnea or; cerebrovascular accidents.
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9.发明授权SUBSTITUIERTE 4-PHENYLTETRAHYDROISOCHINOLINE, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS MEDIKAMENT, SOWIE SIE ENTHALTENDES MEDIKAMENT 有权取代的4- PHENYLTETRAHYDROISOCHINOLINE，工艺所周之，它们作为药品和含药
公开(公告)号：EP1453810B1
公开(公告)日：2009-03-18
申请号：EP02804183.8
申请日：2002-11-20
发明人： HOFMEISTER, Armin , HEINELT, Uwe , LANG, Hans-Jochen , BLEICH, Markus , WIRTH, Klaus , GEKLE, Michael
IPC分类号： C07D217/22 , C07D401/12 , C07D403/12 , C07D417/12 , C07D409/12 , A61K31/47 , A61P9/12
CPC分类号： C07D401/12 , C07D217/18 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The invention relates to compounds of formula (I), wherein R1 - R9 which have the meaning as cited in the claims, are extremely suitable as antihypertensives for reducing or preventing ischemically induced injuries, as medicaments for operative intervention for the treatment of ischemics of the nervous system, strokes and swelling of the brain, shocks, disturbed respiratory functions, for the treatment of snorers, as a laxative, as agents against ectopic parasites, for the prevention of gallstones, as antiatherosclerotic agents, agents against diabetic late complications, cancer, fibrotic diseases, endothelial dysfunctions, organ hypertrophia and hyperplasia. Said compounds are also inhibitors of the cellular sodium-proton-antiporters, they influence serum lipoproteins and can be used in the prophylaxis of and for the regression of atherosclerotic alterations.
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10.发明授权N-SUBSTITUIERTE (BENZOIMIDAZOL-2-YL)-PHENYL-AMINE, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS MEDIKAMENT ODER DIAGNOSTIKUM SOWIE SIE ENTHALTENDES MEDIKAMENT 有权的N-取代的（苯并咪唑-2-基）苯基胺，METHOD FOR THE PRODUCTION，它们作为药物或诊断和药物含
公开(公告)号：EP1592671B1
公开(公告)日：2008-04-09
申请号：EP04703374.1
申请日：2004-01-20
IPC分类号： C07D235/30 , A61K31/4184 , A61P11/00
CPC分类号： C07D235/30
摘要： The invention relates to compounds of formula (I), in which R1 to R7 are defined as cited in the claims. Medicaments containing compounds of this type are used to prevent or treat diverse diseases. Said compounds are used to treat renal diseases such as acute or chronic renal failure, gall-bladder dysfunction, respiratory disorders such as snoring or sleep apnoea, or to treat strokes.
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