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    Enzyme assay method
    11.
    发明公开
    Enzyme assay method 失效
    Enzymatisches Bestimmungsverfahren。

    公开(公告)号：EP0313274A1

    公开(公告)日：1989-04-26

    申请号：EP88309624.0

    申请日：1988-10-14

    申请人： KINGS COLLEGE LONDON

    发明人： Abuknesha, Ramadan Arabi ,  Bennetto, Hugh Peter ,  Mason, Jeremy Richard ,  Nugent, Philip Giles ,  Stirling, John Laing ,  Thurston, Christopher Frank

    IPC分类号： G01N33/58 ,  G01N33/543 ,  G01N33/74 ,  G01N33/533

    CPC分类号： G01N33/581

    摘要： An immunoassay method involves the use of one or preferably two enzyme amplification steps to increase assay speed or sensitivity. In a first step, a first enzyme is generated in an amount related to the concentration of an analyte in a sample. In a second step, the first enzyme acts on a first substrate to reveal antigenic determinants of a first product. In a third step, the first product is reacted with an antibody. The extent of this immune reaction is determined, preferably by means of an enzyme signal system. Two assays for digoxin and one for 17α-­hydroxyprogesterone all using beta-galactosidase as the first enzyme are described.

    摘要翻译： 免疫测定方法包括使用一个或优选两个酶扩增步骤来提高测定速度或灵敏度。 在第一步中，以与样品中分析物的浓度相关的量产生第一酶。 在第二步中，第一种酶作用于第一底物以显示第一产物的抗原决定簇。 第三步，将第一产物与抗体反应。 该免疫反应的程度优选通过酶信号系统来确定。 描述了两种用于地高辛测定和一种用于17α-羟基孕酮的测定，所有这些使用β-半乳糖苷酶作为第一种酶。

    ABRASIVE AGENTS
    16.
    发明公开
    ABRASIVE AGENTS 审中-公开
    研磨介质

    公开(公告)号：EP2296605A2

    公开(公告)日：2011-03-23

    申请号：EP09750089.6

    申请日：2009-05-21

    申请人： KINGS COLLEGE LONDON

    发明人： COOK, Richard, James ,  WATSON, Timothy, F. ,  THOMPSON, Ian, D.

    IPC分类号： A61K6/00 ,  A61K6/083 ,  A61K8/81 ,  A61Q11/00

    CPC分类号： A61K6/0029 ,  C08L33/08

    摘要： The present invention relates to the use of a polyalkenoate acid, such as polyacrylic acid or polymaleic acid, in the manufacture of an air abrasive agent for use in conditioning dental tissue, methods of using such air abrasive agents, dental compositions comprising a polyalkenoate acid, air abrasive agents comprising a polyalkenoate acid and at least one of a bioactive glass, a glycine salt, baking soda and alumina, methods of treatment and/or prophylaxis using an air abrasive agent comprising a polyalkenoate acid.

    NEURAL INTERFACE
    17.
    发明公开
    NEURAL INTERFACE 审中-公开
    神经接口

    公开(公告)号：EP2249915A2

    公开(公告)日：2010-11-17

    申请号：EP09702839.3

    申请日：2009-01-16

    申请人： Cambridge Enterprise Limited ,  KINGS COLLEGE LONDON ,  THE UNIVERSITY OF BIRMINGHAM

    发明人： LACOUR, Stephanie ,  FAWCETT, James ,  FITZGERALD, James ,  TARTE, Edward ,  MCMAHON, Steve

    IPC分类号： A61N1/05 ,  A61B5/04

    CPC分类号： A61N1/0551 ,  A61B5/04001 ,  A61N1/0556 ,  A61N1/326 ,  A61N1/36003

    摘要： This invention relates to the neural interface comprising one or more electrode-coupled microchannels. Each electrode-coupled microchannel comprises a microchannel for accommodating regenerating nerve axons; and one or more electrodes exposed to the interior of said microchannel. The one or more electrodes may comprise (i) a stimulation array suitable for generating an extracellular stimulus current which induces an action potential in an axon in the microchannel; and/or (ii) a recording array which detects an extracellular signal in the microchannel indicative of an action potential in an axon in the microchannel. Interfaces as described may be useful in blocking pain, treating misrouted motor nerves; repair or treating nerve injury; or controlling or providing sensation and/or proprioception from a prosthesis.

    Improvements in or relating to broadcast networks
    19.
    发明公开
    Improvements in or relating to broadcast networks 审中-公开
    Rendfunknetzwerken的Verbesserungen bei oder im Zusammenhang

    公开(公告)号：EP2061166A2

    公开(公告)日：2009-05-20

    申请号：EP08169197.4

    申请日：2008-11-14

    申请人： KINGS COLLEGE LONDON

    发明人： Shanker, Uma ,  Aghvami, Abdol, Hamid ,  Pangalos, Paul, Anthony

    IPC分类号： H04H20/26

    CPC分类号： H04H20/26 ,  H04H20/57 ,  H04H2201/16

    摘要： In a broadcast network environment comprising a first broadcast network and a second broadcast network, each broadcast network for broadcasting a plurality of services, each service identifiable by a respective service identity, and in which mobile receivers are assisted to handover reception of a service from one of said first and second broadcast network to the same or a similar service in the other of said first and second broadcast networks, by transmitting handover data toward said mobile receivers, which handover data comprises a mapping between a service identity of a service in said first broadcast network and a corresponding service identity of the same or a similar service in said second broadcast network, a method of generating said handover data for transmission to said mobile receivers,
    characterised by the steps of said first broadcast network:
    (a) receiving a broadcast signal from said second broadcast network;
    (b) for said service identity in said first broadcast network, using a likely common identifier to search for one or more corresponding service in service information data found in said broadcast signal, whereby if available said corresponding service identity of the same or a similar service in said second broadcast network is discovered.

    摘要翻译： 在包括第一广播网络和第二广播网络的广播网络环境中，每个广播网络用于广播多个服务，每个服务可由相应的服务身份识别，并且其中移动接收机被辅助从一个服务的接收切换 所述第一广播网络和所述第二广播网络通过向所述移动接收机发送切换数据，所述第一广播网络和所述第二广播网络中的另一个广播网络中的另一个广播网络中的相同或类似服务包括所述第一和第二广播网络中的服务的服务标识 广播网络和所述第二广播网络中相同或类似服务的对应服务标识，产生所述移动数据以便发送给所述移动接收机的方法，其特征在于所述第一广播网络的步骤：（a）接收广播 来自所述第二广播网络的信号; （b）对于所述第一广播网络中的所述服务身份，使用可能的公共标识符来搜索在所述广播信号中找到的服务信息数据中的一个或多个对应服务，由此如果有的话，相同或类似服务的相应服务身份 在所述第二广播网络中被发现。

    Methods for producing immunoglobulins containing protection proteins in plants and their use
    20.
    发明公开
    Methods for producing immunoglobulins containing protection proteins in plants and their use 失效
    一种用于生产含有免疫球蛋白和其使用的保护蛋白质的过程

    公开(公告)号：EP1911767A2

    公开(公告)日：2008-04-16

    申请号：EP07113307.8

    申请日：1995-12-27

    申请人： PLANET BIOTECHNOLOGY, INC. ,  KINGS COLLEGE LONDON ,  The Regents of the University of California

    发明人： Hiatt, Andrew ,  Ma, Julian ,  Lehner, Thomas ,  Mostov, Keith

    IPC分类号： C07K16/00 ,  C07K14/705 ,  C12N15/82 ,  C12N15/13 ,  C12N15/12

    CPC分类号： C12N15/8258 ,  C07K14/705 ,  C07K16/00 ,  C12N15/8242

    摘要： The immunoglobulins of the present invention are useful therapeutic immunoglobulins against mucosal pathogens such as S. mutans. The immunoglobulins contain a protective protein that protects the immunoglobulins in the mucosal environment. The invention also includes the greatly improved method of producing immunoglobulins in plants by producing the protection protein in the same cell as the other components of the immunoglobulins. The components of the immunoglobulin are assembled at a much improved efficiency. The method of the invention allows the assembly and high efficiency production of such complex molecules. The invention also contemplates the production of immunoglobulins containing protection proteins in a variety of cells, including plant cells, that can be selected for useful additional properties. The use of immunoglobulins containing protection proteins as therapeutic antibodies against mucosal and other pathogens is also contemplated.

    摘要翻译： 本发明的免疫球蛋白是针对粘膜病原体有用的治疗的免疫球蛋白：如变形链球菌。 免疫球蛋白含有保护性蛋白也保护了环境粘膜免疫球蛋白。 因此本发明包括通过在同一细胞作为免疫球蛋白的其它部件的制造保护蛋白质生产在植物中的免疫球蛋白的大大改进的方法。 免疫球蛋白的组分以显着改善的效率装配。 本发明的方法允许装配和高效率的生产检测复杂分子。 因此，本发明考虑制造中的各种细胞，包括植物细胞的含保护蛋白质的免疫球蛋白，也可以选择用于有用的附加属性。 因而使用含保护蛋白作为对粘膜和其他病原体的治疗性抗体的免疫球蛋白是预期的。