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公开(公告)号：EP3055836B1
公开(公告)日：2019-03-20
申请号：EP14795789.8
申请日：2014-10-13
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公开(公告)号：EP1461601B1
公开(公告)日：2017-08-23
申请号：EP02799106.6
申请日：2002-12-20
发明人： GENET, Magalie , BOURG-HECKLY, Geneviève , VILETTE, Sandrine , LACOMBE, François , LOISEAU, Alexandre , ABRAT, Benjamin
CPC分类号： G01N21/6486 , A61B5/0068 , A61B5/0071 , A61B5/0075 , A61B5/0084 , G01N21/6456
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公开(公告)号：EP2710551B1
公开(公告)日：2015-03-11
申请号：EP12756553.9
申请日：2012-05-16
发明人： SAVOIRE, Nicolas , VERCAUTEREN, Tom
IPC分类号： G06T5/00
CPC分类号： G06T5/20 , G02B21/365 , G06T5/006 , G06T5/008 , G06T2207/10056
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公开(公告)号：EP2459101B1
公开(公告)日：2014-08-20
申请号：EP10768547.1
申请日：2010-07-19
CPC分类号： A61B5/0084 , A61B1/00154 , A61B1/313 , A61B5/0068 , A61B5/0071 , A61B5/6814 , A61B5/6864 , A61B5/6868 , A61B5/6882 , A61B90/11 , A61B2503/40 , A61B2560/063 , A61B2562/0238 , G02B23/26
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公开(公告)号：EP1706017B1
公开(公告)日：2013-11-27
申请号：EP05717462.5
申请日：2005-01-21
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , Observatoire de Paris , Mauna Kea Technologies
IPC分类号： A61B3/00
CPC分类号： A61B3/0091
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16.发明公开DISPOSITIF D'IMAGERIE MODULAIRE, MODULE DE BALAYAGE ET D'INJECTION POUR CE DISPOSITIF ET PROCEDE D'IMAGERIE 审中-公开模块化的摄像装置，用于器件模块及其实现方法与设备
公开(公告)号：EP2198273A2
公开(公告)日：2010-06-23
申请号：EP08843195.2
申请日：2008-10-10
发明人： VIELLEROBE, Bertrand , LACOMBE, François , BOULAROT, Nicolas , DOUSSOUX, François , LAVILLONNIERE, Nicolas
CPC分类号： G01N21/6458 , A61B1/00165 , A61B1/00186 , A61B1/043 , A61B1/0638 , A61B1/07 , A61B5/0068 , A61B5/0071 , A61B5/0084 , G01N2021/6419 , G01N2021/6421 , G01N2201/024 , G01N2201/0846 , G01N2201/086
摘要： An imaging device includes an illumination module comprising at least one emitter for emitting at least one excitation beam; a scanning and injection module comprising an image guide, a proximal end and a distal end of which are linked by a plurality of optical fibers; a scanning and injection optical system configured to alternately inject the at least one excitation beam into an optical fiber of the image guide from the proximal end of the image guide; a detection module comprising a detector for detecting a luminous flux collected at the distal end of the image guide, wherein at least one of the illumination module and the detection module is optically conjugated with the scanning and injection module using a conjugating optical fiber.
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17.发明公开Procédé et appareillage d'imagerie de fluorescence fibrée haute résolution 审中-公开一种用于高分辨率的光纤荧光成像方法和设备
公开(公告)号：EP1986031A3
公开(公告)日：2009-05-20
申请号：EP08159710.6
申请日：2003-07-11
CPC分类号： H04N1/0281 , A61B5/0062 , A61B5/0068 , A61B5/0071 , A61B5/0073 , A61B5/0084 , G02B21/0028 , G02B21/0032 , G02B21/0048 , G02B21/0072 , G02B21/0076 , G02B21/0084 , G02B23/26 , G02B26/101
摘要： Le procédé utilise un guide d'image fait de plusieurs milliers de fibres optiques, un signal d'excitation étant émis par une source, dévié et injecté tour à tour dans l'une des fibres dudit guide, chaque point d'excitation du tissu en sortie de fibre émettant en retour un signal de fluorescence collecté par ladite fibre, puis détecté et numérisé pour former un élément d'image. Selon l'invention, le procédé prévoit de produire un faisceau divergent en sortie de fibre susceptible d'exciter un microvolume du tissu depuis la surface. Selon l'invention, le procédé est caractérisé en ce que l'on dévie le signal d'excitation à une vitesse correspondant à l'acquisition d'un nombre d'images par seconde suffisant pour une utilisation en temps réel et en ce que l'on détecte le signal de fluorescence à une fréquence de détection correspondant à une fréquence minimale d'échantillonnage des fibres une à une.
Grâce à l'invention, on peut réaliser une image in vivo in situ et en temps réel.-
18.发明公开TETE OPTIQUE MINIATURISEE A HAUTE RESOLUTION SPATIALE ET HAUTE SENSIBILITE, NOTAMMENT POUR L'IMAGERIE DE FLUORESCENCE CONFOCALE FIBREE 有权对光纤共聚焦荧光成像特别是高空间分辨率和高灵敏度的微型光学头
公开(公告)号：EP2020896A1
公开(公告)日：2009-02-11
申请号：EP07731377.3
申请日：2007-04-27
发明人： GENET, Magalie , MATHIEU, Gilles , VIELLEROBE, Bertrand , DOUSSOUX, François , BOULAROT, Nicolas , LAVILLONNIERE, Nicolas
CPC分类号： A61B1/00188 , G02B21/0028 , G02B21/0072 , G02B23/243 , G02B27/0025
摘要： The invention concerns a miniaturized optical head provided to equip the distal end of a beam of flexible optical fibres scanned by a laser beam, said optical head being designed to come in contact with a sample and to excite said sample confocally; this optical head consisting of means for correcting spherical aberrations and focusing means. According to the invention, the focusing means comprise: at least a first lens (L4) of high convergence associated with a spherical or hemispherical lens (L5) arranged at the distal end of the optical head, and means for correction of the axial and lateral chromatic aberration provided with a single divergent lens (3b) the curvature of which is substantially centred on the pupil of the optical fibre beam and arranged at the exact distance for this pupil for which the conditions of lateral achromatization coincide with the conditions of axial achromatization; this divergent lens being associated with a second convergent lens (L3a) in the form of a doublet (L3).
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19.发明授权
公开(公告)号：EP1581833B1
公开(公告)日：2008-05-21
申请号：EP03815393.8
申请日：2003-12-12
CPC分类号： G02B21/0072 , A61B1/0008 , A61B1/00172 , G02B21/0028 , G02B23/2407 , G02B26/0875 , G02B26/101
摘要： The invention concerns an optical head comprising: a point source (2b) producing an excitation beam, optical means (12, 13) adapted in particular to converge said optical beam into an excitation point S located in a subsurface plane P relative to the surface of a sample, said plane being perpendicular to the optical axis of the optical head; and means for scanning said excitation point so as to define an observation field in said subsurface plane along two perpendicular scanning directions, a rapid online scanning and a slow columnar scanning. The invention is characterized in that it comprises micro-electrical mechanical systems (MEMS) (14a, b) designed to move in translation along a selected displacement (Dc) at least one of the optical means (12, 13), which is mobile along a direction perpendicular to said optical axis so as to obtain at least one of the scanning directions. The invention provides the advantages of maintaining an axial illumination of the sample and of using a miniature head.
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20.发明公开
公开(公告)号：EP1703837A2
公开(公告)日：2006-09-27
申请号：EP04817613.5
申请日：2004-12-29
CPC分类号： G02B21/0036 , A61B1/00188 , A61B1/05 , G02B7/027 , G02B21/0032
摘要： The invention concerns a miniature confocal optical head (4) for a confocal imaging system, in particular endoscopic, said head comprising a point source (2a) for producing a light beam (13); a ball lens (12) arranged at the tip of the optical head, partly outside, to cause said light beam to converge in an excitation point (19) located in a subsurface field under observation (14) of a sample (15), the digital aperture of said lens and the dimension of the point source being adapted to ensure confocality of the assembly; and scanning means (10, 211, 22) for rotating the point source so that the excitation point (19) scans said field under observation. The inventive system produces a real-time confocal image (about 10 images/sec.) of very high quality and homogeneous in the entire field (the optical aberrations are constant in the entire field due to the spherical symmetry of the ball lens), and this is achieved through a miniature head.
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