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75 条记录 (耗时 0.022 秒)

    Analogs of parathyroid hormone
    14.
    发明公开
    Analogs of parathyroid hormone 失效
    甲状旁腺激素类似物

    公开(公告)号：EP1405861A3

    公开(公告)日：2004-07-21

    申请号：EP03077383.2

    申请日：1996-07-03

    申请人： SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A.S.

    发明人： Dong, Zheng Xin

    IPC分类号： A61K38/29 ,  C07K1/06 ,  C07K14/635

    CPC分类号： C07K14/635 ,  A61K38/00

    摘要： Peptide variants of fragment (1-34) of parathyroid hormone, in which at least one of the amino acid residues at positions 7, 11, 23, 24, 27, 28 and 31 is cyclohexylalanine, or at least one of the amino acid residues at positions 3, 16, 17, 18, 19 and 34 is α-aminoisobutyric acid; or, alternatively, at least the amino acid residue at position 1 is α,β-diaminopropionic acid, the amino acid residue at position 27 is homoarginine, or the amino acid residue at position 31 is norleucine.

    摘要翻译： 甲状旁腺激素片段（1-34）的肽变体，其中7,11,23,24,27,28和31位的至少一个氨基酸残基是环己基丙氨酸，或至少一个氨基酸残基 在位置3,16,17,18,19和34是α-氨基异丁酸; 或者至少第1位的氨基酸残基是α，β-二氨基丙酸，第27位的氨基酸残基是高精氨酸，或第31位的氨基酸残基是正亮氨酸。

    SUSTAINED RELEASE FORMULATION OF A PEPTIDE
    16.
    发明授权
    SUSTAINED RELEASE FORMULATION OF A PEPTIDE 有权
    缓释制剂，肽

    公开(公告)号：EP1204429B1

    公开(公告)日：2003-10-29

    申请号：EP00954105.3

    申请日：2000-08-16

    申请人： SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A.S.

    发明人： MOREAU, Jacques-Pierre

    IPC分类号： A61K47/48

    CPC分类号： A61K47/62 ,  A61K47/593

    摘要： This invention pertains to a sustained release complex, Compound (I), which comprises Compound (A), having formula (A) or a pharmaceutically acceptable salt thereof, and a copolymer comprising poly-(I)-lactic-glycolic-tartaric acid (P(I)LGT), wherein the amino group of said Compound (A) is ionically bound to a carboxyl group of the P(I)LGT. The present invention further pertains to a process for making said sustained release complex. Further still, the present invention is directed to a pharmaceutical composition comprising said sustained release complex and a pharmaceutically acceptable carrier(s).

    Device for parenterally delivering solid drug compositions
    18.
    发明公开
    Device for parenterally delivering solid drug compositions 失效
    Gerätzur肠胃外Abgabe fester Wirkstoffzusammensetzungen

    公开(公告)号：EP1270032A1

    公开(公告)日：2003-01-02

    申请号：EP02017692.1

    申请日：1995-08-31

    申请人： SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A.S.

    发明人： Cherif-Cheikh, Roland

    IPC分类号： A61M5/142

    CPC分类号： A61K9/0024 ,  A61J1/201 ,  A61K9/0019 ,  A61K9/06 ,  A61K9/2018 ,  A61K9/70 ,  A61K38/09 ,  A61K38/25 ,  A61K38/28 ,  A61K38/31 ,  A61K47/26 ,  A61M5/14248 ,  A61M5/1452 ,  A61M5/31531 ,  A61M5/31575 ,  A61M5/31595 ,  A61M37/0069 ,  A61M2005/14268

    摘要： This invention relates to the parenteral administration of solid drug compositions. In particular the invention relates to an external, wearable device for the automatic, controlled administration of a solid drug composition to a patient comprising: a housing (32,34); a plunger (36) located within said housing; a dispensing tube (40) attached to said housing, said tube being designed to contain a solid drug composition consisting essentially of said drug and up to 50%, by weight, of a pharmaceutically acceptable carrier; an actuator (54) arranged within said housing to move said plunger from said housing into said dispensing tube; a controller that acts on said actuator to regulate the movement of said plunger through said housing and into said dispensing tube; and a power source (52) arranged to provide energy to said actuator and said controller; wherein said plunger moves the solid drug composition out of said dispensing tube at a controlled rate.

    摘要翻译： 本发明涉及固体药物组合物的肠胃外给药。 特别地，本发明涉及一种用于将固体药物组合物自动控制施用给患者的外部可穿戴装置，包括：壳体（32,34）; 位于所述壳体内的柱塞（36）; 连接到所述壳体的分配管（40），所述管设计成包含基本上由所述药物和高达50重量％的药学上可接受的载体组成的固体药物组合物; 布置在所述壳体内的致动器（54），用于将所述柱塞从所述壳体移动到所述分配管中; 作用于所述致动器以控制所述柱塞通过所述壳体并进入所述分配管的运动的控制器; 以及电源（52），其布置成向所述致动器和所述控制器提供能量; 其中所述柱塞以固定的速率将固体药物组合物移出所述分配管。

    Encapsulation of water soluble peptides
    19.
    发明公开
    Encapsulation of water soluble peptides 审中-公开
    Einkapseln vonwasserlöslischenPeptiden

    公开(公告)号：EP1240896A2

    公开(公告)日：2002-09-18

    申请号：EP02076666.3

    申请日：1999-07-09

    申请人： SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A.S.

    发明人： Ignatious, Francis X

    IPC分类号： A61K9/16 ,  A61K38/00

    CPC分类号： A61K9/1694 ,  A61K9/1647 ,  B01J13/02

    摘要： A process for preparing polymer microspheres and nanospheres comprising a polymer and a peptide, which comprises the steps of:

    dissolving a salt of a peptide complexed with an anionically or cationically functionalized biodegradable polyester in an organic solvent to form a solution;
    dispersing the solution in an aqueous solution of a surfactant; and
    evaporating the organic solvent to isolate the polymer microspheres and nanospheres.

    摘要翻译： 一种制备包含聚合物和肽的聚合物微球和纳米球的方法，其包括以下步骤：将与阴离子或阳离子官能化的可生物降解聚酯络合的肽的盐溶解在有机溶剂中以形成溶液; 将溶液分散在表面活性剂的水溶液中; 并蒸发有机溶剂以分离聚合物微球和纳米球。