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公开(公告)号：EP2699591A4
公开(公告)日：2014-05-07
申请号：EP12774217
申请日：2012-04-17
发明人： PERI KRISHNA G , HABI ABDELKRIM
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公开(公告)号：EP2382984A2
公开(公告)日：2011-11-02
申请号：EP11168850.3
申请日：2003-05-29
IPC分类号： A61K38/25
摘要： There is provided a GRF compound or analog thereof for use in improving daytime vigilance and/or cognitive function in a subject.
摘要翻译： 提供了GRF化合物或其类似物用于改善受试者的白天警觉和/或认知功能。
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14.发明公开BIFUNCTIONAL FUSION PROTEINS OF THE ALPHA-MELANOCYTE STIMULATING HORMONE (ALPHA-MSH) AND ATRIAL NATRIURETIC PROTEIN (ANP) AND USES IN HYPERTENSION AND ACUTE KIDNEY INJURY 审中-公开双功能融合蛋白的所述α-黑素细胞刺激素（ALPHA-MSH）和蛋白心房钠尿（ANP）及它们在高压及急性肾损伤
公开(公告)号：EP2173773A4
公开(公告)日：2010-07-07
申请号：EP08783182
申请日：2008-07-04
发明人： PERI KRISHNA , HABI ABDELKRIM
IPC分类号： C07K19/00 , A61K38/22 , A61P9/12 , A61P13/12 , C07K14/575 , C07K14/58 , C07K14/685
CPC分类号： C07K14/575 , C07K14/58 , C07K14/68 , C07K14/685 , C07K2319/00
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15.发明公开BIFUNCTIONAL FUSION PROTEINS OF THE ALPHA-MELANOCYTE STIMULATING HORMONE (ALPHA-MSH) AND ATRIAL NATRIURETIC PROTEIN (ANP) AND USES IN HYPERTENSION AND ACUTE KIDNEY INJURY 审中-公开双功能融合蛋白的所述α-黑素细胞刺激素（ALPHA-MSH）和蛋白心房钠尿（ANP）及它们在高压及急性肾损伤
公开(公告)号：EP2173773A1
公开(公告)日：2010-04-14
申请号：EP08783182.2
申请日：2008-07-04
发明人： PERI, Krishna , HABI, Abdelkrim
IPC分类号： C07K19/00 , A61K38/22 , A61P13/12 , A61P9/12 , C07K14/575 , C07K14/58 , C07K14/685
CPC分类号： C07K14/575 , C07K14/58 , C07K14/68 , C07K14/685 , C07K2319/00
摘要： A bifunctional hormone exhibiting an alpha-MSH activity and a natriuretic peptide activity is described. The bifunctional hormone comprises for example a first domain having alpha-MSH related hormonal activity covalently linked to a second domain having natriuretic peptide related hormonal activity. The bifunctional hormone of the present invention is useful for example for the prevention and/or treatment of renal related diseases or conditions, such as acute renal failure (ARF) or acute kidney injury (AKI).
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公开(公告)号：EP1628676A1
公开(公告)日：2006-03-01
申请号：EP03724755.8
申请日：2003-05-29
摘要： The present invention relates to compositions for improving daytime vigilance and/or cognitive function, for improving a metabolic condition, for improving anabolism in a catabolic condition and for improving and/or reconstituting immune function in a subject, the composition comprising an effective amount of a GRF compound or analog thereof in association with a pharmaceutically acceptable carrier, excipient or diluent.
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17.发明公开PROCESS FOR THE PREPARATION OF PLATELET GROWTH FACTORS EXTRACT FOR WOUND HEALING COMPOSITIONS 失效用于生产SLIDE生长因子筹备工作的提取物用于伤口愈合
公开(公告)号：EP1007061A1
公开(公告)日：2000-06-14
申请号：EP97908091.8
申请日：1997-03-19
IPC分类号： A61K35/14
CPC分类号： A61K38/39 , A61K35/19 , A61K38/18 , A61K38/38 , A61K2300/00
摘要： The present invention relates to a process for the preparation of porcine platelet-extract containing matured growth factors, which comprises the steps of: a) centrifuging whole porcine blood at about 1000 g to about 5000 g to isolate the platelets from the platelet-rich-plasma; b) resuspending the isolated platelets of step a) in Plasma-Lyte A and centrifuging to concentrate the platelets; c) washing the concentrated platelets of step b); d) lyophilizing the washed platelets of step c); whereby causing lysis of the platelets and producing the platelet extract in optimal amount.
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18.发明公开CHIMERIC FATTY BODY-PRO-GRF ANALOGS WITH INCREASED BIOLOGICAL POTENCY 失效CHIMERA脂质体PRO-GRF与生物效价ERHÖHETERANALOG
公开(公告)号：EP0828758A1
公开(公告)日：1998-03-18
申请号：EP96914826.0
申请日：1996-05-22
发明人： IBEA, Michel , ABRITAT, Thierry , BRAZEAU, Paul
CPC分类号： C07K14/60 , A61K38/00 , Y10S930/12
摘要： The present invention relates to chimeric fatty body-pro-GRF analogs with increased biological potency, their application as anabolic agents and in the diagnosis and treatment of growth hormone deficiencies. The chimeric fatty body-pro-GRF analogs include a hydrophobic moiety (tail), and can be prepared, either by anchoring one or several hydrophobic tails to the GRF, or by substituting one or several amino-acids by a pseudomicellar residue in the chemical synthesis of GRF. The GRF analogs of the present invention are biodegradable, non-immunogenic and exhibit an improved anabolic potency with a reduced dosage and prolonged activity.
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19.发明授权FORMULATIONS OF GROWTH HORMONE RELEASING FACTOR (GRF) MOLECULES WITH IMPROVED STABILITY 有权具有改善的稳定性的生长激素释放因子（GRF）分子的制剂
公开(公告)号：EP2961432B1
公开(公告)日：2018-04-25
申请号：EP14756414.0
申请日：2014-02-26
发明人： SHINGEL, Kirill , FLEURY, Daniel
CPC分类号： A61K38/26 , A61K9/0019 , A61K38/25 , A61K47/40 , A61K47/542 , A61K47/61
摘要： Stabilized solid and liquid pharmaceutical formulations comprising a GRF molecule as active ingredient, such as GRF analogs including those comprising an N-terminal-attached hydrophobic moiety, such as [trans-3-hexenoyl]hGHRH (1-44) amide, are disclosed. The formulation comprises a GRF molecule or a pharmaceutically acceptable salt thereof and a &bgr;-cyclodextrin which is not conjugated to the GRF molecule or salt thereof. Also disclosed is the use of the formulation for the treatment of various conditions, methods of preparing the formulation, as well as kits containing it. Methods of stabilizing (e.g., with respect to chemical stability) such GRF molecules, as well as methods of inhibiting their deamidation at Asn8, are also disclosed.
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20.发明授权
公开(公告)号：EP1511764B1
公开(公告)日：2012-08-22
申请号：EP03735223.4
申请日：2003-06-11
摘要： The invention relates to compositions which are useful for inhibiting prostaglandin F2alpha receptor. The compositions include, but are not limited to, linear peptides, peptide analogs, and peptidomimetics. Methods of using the compositions of the invention to treat preterm labor and dysmenorrhea are disclosed.
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