利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

85 条记录 (耗时 0.018 秒)

    NOVEL PHOSPHOTRIAZOLE MRNA 5'-END CAP ANALOGS, COMPOSITION COMPRISING THE SAME, RNA MOLECULE INCORPORATING THE SAME, USES THEREOF AND METHOD OF SYNTHESIZING RNA MOLECULE, PROTEIN OR PEPTIDE
    11.
    发明公开
    NOVEL PHOSPHOTRIAZOLE MRNA 5'-END CAP ANALOGS, COMPOSITION COMPRISING THE SAME, RNA MOLECULE INCORPORATING THE SAME, USES THEREOF AND METHOD OF SYNTHESIZING RNA MOLECULE, PROTEIN OR PEPTIDE 审中-公开

    公开(公告)号：EP3484907A1

    公开(公告)日：2019-05-22

    申请号：EP17754482.2

    申请日：2017-07-12

    申请人： Uniwersytet Warszawski

    发明人： WALCZAK, Sylwia ,  KOWALSKA, Joanna ,  JEMIELITY, Jacek

    IPC分类号： C07H21/02 ,  C07H21/04 ,  C12N15/67 ,  A61K31/7084

    摘要： The object of the invention is a compound of formula (I), or a stereoisomer or salt thereof, wherein R1 and R2 are selected from the group consisting of N, N+-CH3, N+-C2H5, N+-C3H8, N+- C4H5, N+-CH2C6H5 wherein at least one of R1, R2 is not N. n and m are independently chosen from the group consisting of 0, 1 and 2; X is selected from the group consisting of O, NH, S, CH2 k is 1 or 2 Y is either void or selected from the group of -CH2-, -CH2CH2-, -CH2O-, -CH2S-, -CH2NH-, - CH2CH2O-, -CH2CH2NH-, -CH2CH2S- R3, R4, R5, R6 are selected from the group consisting of H, OH, OCH3, or OCH2CH3; wherein R3 and R4 may be the same or different; R5 and R6 may be the same or different; if either of R3, R4 is different than OH than R5 and R6 are both OH; if either of R5, R6 is different than OH than R3 and R4 are both OH. The object of the invention is also a composition comprising the compound of the invention, an RNA molecule incorporating the same, uses thereof and a method of synthesizing, in vitro or in vivo, the RNA molecule, as well as a method of synthesizing a protein or peptide in vitro, or in vivo or in cultured cells, said method comprising translating the RNA molecule.

    A METHOD OF SYNTHESIS OF UNSOLVATED MIXED CATION BOROHYDRIDES
    12.
    发明公开
    A METHOD OF SYNTHESIS OF UNSOLVATED MIXED CATION BOROHYDRIDES 审中-公开
    一种合成无溶剂混合阳离子硼氢化合物的方法

    公开(公告)号：EP3164358A1

    公开(公告)日：2017-05-10

    申请号：EP14789366.3

    申请日：2014-09-18

    申请人： Uniwersytet Warszawski

    发明人： JARO , Tomasz ,  WEGNER, Wojciech ,  GROCHALA, Wojciech

    IPC分类号： C01B6/24

    CPC分类号： C01B6/246

    摘要： The present invention relates to a novel method of synthesis of unsolvated mixed cation borohydrides of a general formula Μ
    x Μ'
    y (ΒΗ
    4 )
    z , where M and M' stand for metal cations, x, y and z are stoichiometric coefficients. The method of synthesis according to the present invention is characterized in that the precursors having a general formula M[An]
    u and [Cat]
    v M'(BH
    4 )
    w are used for the synthesis, where [An] stands for a weakly coordinating anion; [Cat] stands for a weakly coordinating cation; u, v and w are the stoichiometric coefficients; and the synthesis is carried out under an inert to the reagents atmosphere - according to the general reaction equation: x M[An]
    u + y [Cat]
    v M'(BH
    4 )w → M
    x M'
    y (BH
    4 )
    z + xu [Cat][An] where z = yw, xu = yv; M
    x M'
    y (BH
    4 )
    z is the product of the reaction; [Cat][An] is the by-product of the reaction which can be separated from the product using a properly selected solvent or a mixture of solvents, which neither dissolves, nor solvates the product M
    x M'
    y (BH
    4 )
    z , while completely dissolves the by-product [Cat] [An]. The method according to the present invention allows obtaining unsolvated mixed cation borohydrides in a pure form without impurities. The process is quick, efficient and environmentally friendly. Using the method according to the present invention it is possible to easily design composition of the synthesised mixed cation borohydrides. An additional advantage is the possibility of synthesis of simple borohydrides, which can not be obtained in a pure form using previously known methods.

    摘要翻译： 本发明涉及合成通式为M x M'y（BH 4）z的非溶剂化混合阳离子硼氢化物的新方法，其中M和M'代表金属阳离子，x，y和z是化学计量系数。 根据本发明的合成方法的特征在于具有通式M [An] u和[Cat] vM'（BH4）w的前体用于合成，其中[An]代表弱配位阴离子 ; [Cat]代表弱配位阳离子; u，v和w是化学计量系数; 根据以下一般反应方程式对反应气氛进行合成：x M [An] u + y [Cat] v M'（BH4）w→MxM'y（BH4）z + xu [ Cat] [An]其中z = yw，xu = yv; MxM'y（BH4）z是反应的产物。

    NOVEL PEPTIDOMIMETICS WITH ANTIANGIOGENIC ACTIVITY
    13.
    发明公开
    NOVEL PEPTIDOMIMETICS WITH ANTIANGIOGENIC ACTIVITY 有权
    牛皮EN EN IT IT IT IT IT IT IT IT IT IT IT IT IT IT IT IT IT IT IT

    公开(公告)号：EP3036251A1

    公开(公告)日：2016-06-29

    申请号：EP14780911.5

    申请日：2014-08-23

    申请人： Uniwersytet Warszawski

    发明人： MISICKA-KESIK, Aleksandra ,  TYMECKA, Dagmara ,  FEDORCZYK, Bartlomiej ,  SOSNOWSKI, Piotr ,  WILENSKA, Beata ,  WITKOWSKA, Ewa ,  LADAM, Patrick ,  PERRET, Gerard Y.

    IPC分类号： C07K5/02

    CPC分类号： C07K5/0215 ,  A61K38/00

    摘要： 25 Abstract We disclose novel peptidomimetics with antiangiogenic activity and their uses, particularly in the treatment of neoplasms and chronic inflammation (in particular of: rheumatoid arthritis, colitis), in eczema, diabetes, age-related macular degeneration (ARMD), nephropathy and neuropathy, in particular for use in the form of intravenous infusions or injections, or implants releasing the active ingredient.

    摘要翻译： 我们公开具有抗血管生成活性的新型肽模拟物及其用途，特别是在治疗赘生物和慢性炎症（特别是类风湿性关节炎，结肠炎），湿疹，糖尿病，年龄相关性黄斑变性（ARMD），肾病和神经病变中的用途 特别用于静脉内输注或注射的形式，或释放活性成分的植入物。

    New derivatives of phenyl 3-phenylbutyrate, a method of obtaining new derivatives of phenyl 3-phenylbutyrate and the application of new derivatives of phenyl 3-phenylbutyrate for liquid crystalline mixtures
    16.
    发明公开
    New derivatives of phenyl 3-phenylbutyrate, a method of obtaining new derivatives of phenyl 3-phenylbutyrate and the application of new derivatives of phenyl 3-phenylbutyrate for liquid crystalline mixtures 失效
    苯基3-苯基丁酸的酯衍生物，涉及用于苯基3-Phenylbuttersäureestern的新衍生物的制备和使用对于液晶混合物的苯基3-Phenylbuttersäureestern的新衍生物的方法。

    公开(公告)号：EP0337489A2

    公开(公告)日：1989-10-18

    申请号：EP89106741.5

    申请日：1989-04-14

    申请人： UNIWERSYTET WARSZAWSKI

    发明人： Pyzuk, Wieslaw Jan ,  Boncza-Tomaszewski, Zbigniew ,  Krupkowski, Teodor

    IPC分类号： C07C79/46 ,  C09K19/20 ,  C09K19/30 ,  C09K19/24 ,  C07C69/75 ,  C07C107/06 ,  C07C105/00 ,  C07C121/75

    CPC分类号： C07C255/00 ,  C07C205/56 ,  C07C245/08 ,  C09K19/2028 ,  C09K19/24 ,  C09K19/3001

    摘要： The subject of the invention are new derivatives of phenyl 3-phenylbutyrate and a method of obtaining new derivatives of phenyl 3-phenylbutyrate of the general formula 1,
    wherein
    A denotes a hydrogen atom, the radical C₁-C₁₂-alkyl, the residue -O(C₁-C₁₂-alkyl), -CO(C₁-C₁₂-alkyl), -COO(C₁-C₁₂-alkyl), -OOC(C₁-C₁₂-alkyl) and the group -CN, -NCS or -NO₂,
    B denotes residues of formulas
    wherein R denotes substituents mentioned for A, R′ denotes the radical C₁-C₁₂-alkyl, while X denotes the group -N=N-, -N(O)N-, -COO- or -OOC-,
    consisting in that the acid of the general formula 2
    wherein A has the above mentioned meaning,
    or in the form of an acid chloride, is reacted with phenol of the general formula 3
    wherein B has the above mentioned meaning.
    New derivatives of phenyl 3-phenylbutyrate are applied for the preparation of chiral or achiral liquid-crystall­ine mixtures.

    摘要翻译： 本发明的主题是苯基-3-苯基丁并获得通式1的苯基3-苯基丁的新衍生物的方法的新的衍生物， worin A表示氢原子，基团C 1 -C 12烷基时，该 残余物-O（C1-C12烷基）， - CO（C1-C12烷基），-COO（C1-C12烷基），-OOC（C1-C12烷基）和基团-CN，-NCS或 - NO 2，B表示通式 worin R表示提到的A，R取代基“表示基团C 1 -C 12烷基，而X表示基团-N = N-，-N（O）N，COO的残基 - 或--OOC--，在DASS由......组成死通式酸2 worin A具有上述含义，或者在的酰氯的形式，进行反应与通式3 worin B的苯酚 具有上述含义。 苯基-3-苯基丁的新衍生物的应用手性或非手性液晶的混合物的制备。