公开(公告)号：EP2008669A1

公开(公告)日：2008-12-31

申请号：EP07012298.1

申请日：2007-06-22

申请人： Maco Pharma S.A.

发明人： Walker, Wolfram Hubert ,  Tolksdorf, Frank ,  Verpoort, Thierry ,  Goudaliez, Francis ,  Behague, Maurice ,  Chavatte, Arnaud

IPC分类号： A61L2/10 ,  A61K41/00 ,  A61M1/36 ,  C12N7/04

CPC分类号： A61L2/0047 ,  A61K41/0019 ,  A61L2/0011 ,  A61L2/10 ,  A61M1/0277

摘要： The invention relates to an irradiation apparatus for inactivating pathogens and/or leukocytes in a biological fluid such as a platelet suspension and/or plasma comprising : a casing 2, a support member 3 for carrying at least one irradiation bag containing the biological fluid, a light source 4 comprising two banks of light 5,6 disposed above and below the support member 3, and an agitating system 25 for moving the support member 3, the light source generating UVC light of suitable intensity to inactivate pathogens and/or leukocytes and the agitation system moving the support member in an orbital path with predetermined with predetermined amplitude and rotational frequency suitable to expose the whole biological fluid to UVC.

摘要翻译： 本发明涉及在照射装置用于灭活病原体和/或白细胞在生物流体：如血小板悬浮液和/或等离子体，包括：壳体2，用于承载至少一个照射袋含有生物流体中的支撑件3，一 lightsource 4包括光5,6-上方和下方支撑件3设置在两个银行，并且在搅动系统25，用于移动支撑部件3，该光源产生适合强度的UVC光以灭活病原体和/或白细胞和 搅拌系统在轨道路径移动所述支撑部件与预定的振幅和适合于整个生物流体暴露于UVC旋转频率预先确定。

公开(公告)号：EP1614694A4

公开(公告)日：2008-11-05

申请号：EP04724768

申请日：2004-03-31

申请人： TOTO LTD

发明人： SONEZAKI SHUJI ,  KANEHIRA KOKI ,  YAGI SHINICHI ,  OGAMI YUMI

IPC分类号： A61P43/00 ,  A61K9/00 ,  A61K33/24 ,  A61K41/00 ,  A61K47/02 ,  A61K47/48 ,  A61L2/16 ,  A61P35/00 ,  C07K17/14 ,  G01N33/554

CPC分类号： A61K41/0019 ,  A61K9/0014 ,  A61K33/24 ,  A61K41/0042 ,  A61K47/02 ,  A61K47/6883 ,  A61K47/6923 ,  A61K47/6929 ,  A61L2/16 ,  B82Y5/00 ,  C07K17/14 ,  G01N33/554

摘要： A titanium dioxide complex capable of distinguishing molecules is obtained by modifying the surface of a fine titanium dioxide particle with a hydrophilic polymer in such a manner that titanium dioxide is bonded via an ester bond to a carboxyl group of the hydrophilic polymer and immobilizing a molecule having an ability to specifically bind to a target molecule to the carboxyl residue of the hydrophilic polymer. Due to the molecule distinguishability, this titanium dioxide complex can bind specifically to an endocrine disrupting chemical, a pathogenic factor, a cancer cell, etc. and decompose the same by a photocatalytic function.

公开(公告)号：EP0840624B1

公开(公告)日：2007-07-25

申请号：EP96923791.6

申请日：1996-07-15

申请人： CAF - DCF cvba - scrl

发明人： LAUB, Ruth ,  DE WAEL, Luc ,  DI GIAMBATTISTA, Mario

IPC分类号： A61L2/10 ,  A61K35/14 ,  A61L2/24

CPC分类号： A61L2/0011 ,  A61K35/14 ,  A61K41/0019 ,  A61M1/3681 ,  A61M2205/053

摘要： A method for inactivating parvoviruses in a blood product, wherein the blood product is exposed to one or more emissions of ultraviolet C radiation.

公开(公告)号：EP1701740A1

公开(公告)日：2006-09-20

申请号：EP04802247.9

申请日：2004-12-02

申请人： UNIVERSITE DE MONTREAL ,  Hopital Maisonneuve-Rosemont

发明人： ROY, Denis Claude ,  VAILLANCOURT, Marc ,  VILLENEUVE, Luc

IPC分类号： A61K41/00 ,  A61N5/06 ,  A61K35/04 ,  A61K35/12 ,  A61K39/00 ,  A61P7/02

CPC分类号： A61K31/353 ,  A61K31/365 ,  A61K35/28 ,  A61K38/193 ,  A61K38/2013 ,  A61K38/21 ,  A61K39/0008 ,  A61K39/0011 ,  A61K41/0019 ,  A61K41/0057 ,  A61K2039/5154 ,  Y02A50/414 ,  A61K2300/00

摘要： The present invention relates to the use of PDT-treated cells (whole or fragments thereof) and/or supernatant thereof in the preparation of vaccines for immunoprotection or immunomodulation. More particularly, the use of PDT-treated cells (whole or fragments thereof) and/or supernatant thereof in the preparation of an immunologic compound for prevention, protection, prophylaxis or treatment of an immunological disorder, infection and/or a cancer in an individual, which comprises treatment of the individual cells or components thereof with a photoactivatable molecule selected from the group consisting of compounds I to XVIII, wherein the photoactivatable molecule is activated by a light of appropriate wavelength, thereby activating the photoactivatable molecule and causing prevention, protection, prophylaxis or treatment of the immunological disorder, infection and/or a cancer.

公开(公告)号：EP1531823A2

公开(公告)日：2005-05-25

申请号：EP03799774.9

申请日：2003-05-12

申请人： THE OHIO STATE UNIVERSITY

发明人： PLATZ, Matthew, S.

IPC分类号： A61K31/50 ,  A61K31/501 ,  A61K31/497 ,  C07H19/207

CPC分类号： C07D475/14 ,  A61K31/525 ,  A61K31/7056 ,  A61K41/00 ,  A61K41/0019 ,  A61K41/0038 ,  A61K45/06 ,  A61K2300/00

摘要： Compounds comprising flavin N-oxides for treatments of solid tumors, non-solid tumor masses, leukemias, and non-small cell lung cancers and for eradicating contaminants in blood products. Methods of treating patients having solid type cancers comprising administering a therapeutically effective amount of flavin N-oxide to a subject in need of treatment and exposing the flavin n-oxide to an activator such that activation of the flavin N-oxide results in damage to the DNA in the cancer cells without substantial damage to the DNA of normal cells are also provided. Methods of using a flavin N-oxide as part of a combination therapy with chemotherapy, radiation therapy, or both are also provided. methods of reducing pathogenic bacterial or rival contamination in a composition comprising a) mixing the composition with an efficacious amount of flavin N-oxide and b) exposing the mixture of the composition and the flavin N-oxide to an activator for a period of time sufficient to activate the flavin N-oxide such that the flavin N-oxide reduces the contamination in the composition are also provided. Preferably, the composition is a blood product selected from plasma, platelets, and red blood cells, and the activator is an enzyme.

公开(公告)号：EP1530571A1

公开(公告)日：2005-05-18

申请号：EP03751901.4

申请日：2003-08-25

申请人： Gambro, Inc.

发明人： LOCKERBIE, Robert, Owen ,  KUMAR, Vijay ,  KEIL, Shawn, D. ,  GOODRICH, Raymond, P.

IPC分类号： C07D475/14 ,  A61L2/00 ,  A61L2/08 ,  A61L2/10

CPC分类号： A61L2/0082 ,  A61K41/0019 ,  A61L2/0011 ,  A61M1/3681 ,  A61M1/3683

摘要： A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process comprises adding to the blood or blood component containing pathogens an effective amount of riboflavin, and exposing the fluid to light of an appropriate wavelength to damage the nucleic acid of the pathogen and to substantially maintain the damage to the pathogenic nucleic acids to allow for subsequent transfusion into a recipient.

摘要翻译： 一种损害和维护病原体核酸如血液或血液成分中可能含有的白细胞，细菌和病毒的损害的方法。 该方法包括向含有病原体的血液或血液成分中加入有效量的核黄素，并将该液体暴露于适当波长的光以损害病原体的核酸，并基本维持致病性核酸的损伤，以允许 随后输血到接受者。

公开(公告)号：EP1283047A4

公开(公告)日：2005-01-26

申请号：EP00935752

申请日：2000-02-29

申请人： OWEN HOLDING LTD

发明人： SHESTAKOV VITALY ALEXANDROVICH ,  SHESTAKOVA EKATERINA VITALIEVN

IPC分类号： A61K35/16 ,  A61K38/02 ,  A61K38/17 ,  A61K41/00 ,  A61P15/10 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P27/16

CPC分类号： A61K35/16 ,  A61K38/1709 ,  A61K41/00 ,  A61K41/0019

摘要： The invention relates to medicine and can be used for producing a bioactive substance from the blood serum of domestic animals and poultry. The inventive substance is used for curing or correcting an ear disturbance, a sexual activity, spatial memory, for stimulating the proliferation of brain embryo cells and also for treating Parkinson's disease. The active substance is a special fraction of a low-molecular peptide (a.m.u. of 2-4 thousand daltons) obtained by exposing the blood to X-ray radiation (in vitro) and by a sequential separation of the required product.

公开(公告)号：EP1487494A2

公开(公告)日：2004-12-22

申请号：EP03713709.8

申请日：2003-02-26

申请人： North Shore-Long Island Jewish Research Institute

发明人： IVANOVA, Svetlana, M. ,  TRACEY, Kevin, J.

IPC分类号： A61K45/00 ,  A61K31/341 ,  A61K38/16 ,  A61K31/27 ,  A61P29/00

CPC分类号： A61K31/00 ,  A61K31/155 ,  A61K31/341 ,  A61K41/0019 ,  A61N1/32 ,  Y02A50/385 ,  Y02A50/411

摘要： Methods for inhibiting pro-inflammatory cytokine release or inflammation in a vertebrate are provided. The methods comprise activating a brain muscarinic receptor of the vertebrate, or directly stimulating a vagus nerve pathway in the brain of the vertebrate. Also provided are methods for conditioning a vertebrate to inhibit the release of a pro-inflammatory cytokine or reduce inflammation in the vertebrate upon experiencing a sensory stimulus. The methods comprise (a) activating a muscarinic brain receptor or directly stimulating the vagus nerve pathway in the brain of the vertebrate and providing the sensory stimulus to the vertebrate within a time period sufficient to create an association between the stimulus and the activation of the brain muscarinic receptor; and (b) repeating step (a) at sufficient time intervals and duration to reinforce the association sufficiently for the inflammation to be reduced by the sensory stimulus alone.

公开(公告)号：EP1456359A2

公开(公告)日：2004-09-15

申请号：EP02805649.7

申请日：2002-12-20

申请人： Gambro, Inc.

发明人： GOODRICH, Raymond, P.

IPC分类号： C12N7/04 ,  A61K39/00 ,  A61K39/02 ,  A61K39/12 ,  A61L2/08 ,  A61L2/16

CPC分类号： A61K41/0019 ,  A61K39/00 ,  A61K2039/521 ,  A61K2039/5252

摘要： Methods are provided for treating a vaccine containing infectious particles which may be viral, bacterial, and/or cellular in nature. Preferred methods include the steps of adding an effective, non-toxic amount of an endogenous photosensitizer to the fluid and exposing the fluid to photoradiation sufficient to inactivate the infectious particles but not enough to damage the antigenic characteristics of the infectious particles.

公开(公告)号：EP1382572A1

公开(公告)日：2004-01-21

申请号：EP03007518.8

申请日：2003-04-01

申请人： Vast Light Ltd.

发明人： Wong, Chi-Kin Tommy

IPC分类号： C02F1/32 ,  A61L2/10 ,  A61L9/20 ,  A23L3/28

CPC分类号： C02F1/325 ,  A23L3/28 ,  A61K41/0019 ,  A61L2/10 ,  A61L9/20 ,  C02F2201/328 ,  C02F2301/024 ,  C02F2301/026 ,  C02F2303/04 ,  H05B3/0085

摘要： A turbine-boosted ultraviolet-radiation sterilizing fluid processor that includes a quartz sleeve installed inside a tube unit, an ultraviolet-radiation lamp, a fluid inlet tube and a fluid outlet tube arranged at the upper and lower end of the tube unit respectively. A diversion mechanism is disposed under the fluid inlet tube. The diversion mechanism is composed of a plurality of diversion channels arranged in a ring unit. The total area of the fluid outlet hole of the diversion channel is smaller than the cross-sectional area of the passage of said tube unit so as to form a fluid-pressurizing chamber on top of the tube unit. Thus a whirlpool spinning at a high speed is created so that the fluid is blended properly. The fluid spinning at high speed also flushes the wall of the quartz sleeve thus increasing the sterilizing effects and reducing the frequency of maintenance.

摘要翻译： 一种涡轮增压紫外线辐射灭菌流体处理器，其包括安装在管单元内的石英套筒，紫外线辐射灯，流体入口管和流体出口管，分别布置在管单元的上端和下端。 分流机构设置在流体入口管的下方。 引导机构由设置在环形单元中的多个分流通道构成。 导流通道的流体出口孔的总面积小于所述管单元的通道的横截面积，以便在管单元的顶部上形成流体加压室。 因此，产生高速旋转的涡流，使得流体适当地混合。 流体高速旋转也冲刷石英套筒的壁，从而增加了消毒效果，降低了维护的频率。