公开(公告)号：EP4219760A3

公开(公告)日：2023-09-06

申请号：EP23156882.5

申请日：2009-11-10

申请人： Battelle Memorial Institute ,  The Institute for Systems Biology ,  The Ohio State University Research Foundation

发明人： GALAS, David ,  GELINAS, Richard, Evan ,  MARSH, Clay, Braden ,  PIPER, Melissa, Garnet ,  WANG, Kai ,  ZHANG, Shile

IPC分类号： C12Q1/6883 ,  C12Q1/6886

摘要： Methods, compositions, and devices are disclosed which use microRNA to detect, predict, treat, and monitor physiological conditions such as disease or injury. microRNA are isolated and their differential expression is measured to provide diagnostic information. This information may then be utilized for evaluation and/or treatment purposes.

公开(公告)号：EP2846689B1

公开(公告)日：2018-11-21

申请号：EP13787687.6

申请日：2013-05-09

申请人： The Ohio State University

发明人： KOLIPAKA, Arunark ,  ARNOLD, John, W. ,  LEE,F., Paul ,  WHITE, Richard, D.

IPC分类号： A61B5/055 ,  A61B5/00 ,  G01R33/563

CPC分类号： A61B5/0555 ,  A61B5/0051 ,  A61B5/055 ,  F04C2270/041 ,  G01R33/56358

摘要： A system for inducing tissue vibration for magnetic resonance elastography is described. The system includes a passive actuator component, a first hose, a second hose, and a driving component. The passive actuator component is positionable proximate to a target tissue and includes a linearly movable piston assembly enclosed in a housing. The driving component includes a fluid pumping system and is configured to alternatingly pump a fluid through the first hose and through the second hose. When fluid is pumped through the first hose, the piston assembly moves in a first linear direction and, when fluid is pumped through the second hose, the piston assembly moves in the opposite direction. The alternating linear movement of the piston assembly induces vibration in the target tissue.

公开(公告)号：EP2364367B8

公开(公告)日：2017-08-23

申请号：EP09760657.8

申请日：2009-11-10

申请人： Battelle Memorial Institute ,  Institute for Systems Biology ,  The Ohio State University Research Foundation

发明人： GALAS, David ,  GELINAS, Richard, Evan ,  MARSH, Clay, Braden ,  PIPER, Melissa, Garnet ,  WANG, Kai ,  ZHANG, Shile

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q1/6827 ,  C12Q1/6883 ,  C12Q2600/142 ,  C12Q2600/158 ,  C12Q2600/178

摘要： Methods, compositions, and devices are disclosed which use microRNA to detect, predict, treat, and monitor physiological conditions such as disease or injury. microRNA are isolated and their differential expression is measured to provide diagnostic information. This information may then be utilized for evaluation and/or treatment purposes.

摘要翻译： 公开了使用微RNA来检测，预测，治疗和监测诸如疾病或损伤的生理状况的方法，组合物和装置。 分离microRNA并测量其差异表达以提供诊断信息。 该信息然后可以用于评估和/或治疗目的。

公开(公告)号：EP2642856B1

公开(公告)日：2017-07-19

申请号：EP11843945.4

申请日：2011-11-21

申请人： The Ohio State University Research Foundation

发明人： CHEN, Ching-shih ,  LEE, Su-lin ,  KULP, Samuel, K.

IPC分类号： A01N43/56 ,  A61K31/415

CPC分类号： C07D231/14 ,  C07D231/12

公开(公告)号：EP1794354B1

公开(公告)日：2017-06-14

申请号：EP05858518.3

申请日：2005-09-09

申请人： HONDA MOTOR CO., LTD. ,  THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION

发明人： HARUTYUNYAN, Avetik ,  FERNANDEZ, Elena Mora ,  TOKUNE, Toshio

IPC分类号： C01B32/159 ,  C01B32/162 ,  B82Y30/00 ,  B82Y40/00 ,  D01F9/127

CPC分类号： C01B32/162 ,  B82Y30/00 ,  B82Y40/00 ,  C01B2202/02 ,  C01B2202/36 ,  D01F9/127 ,  D01F9/1272

摘要： Method and processes for synthesizing single-wall carbon nanotubes is provided. A carbon precursor gas is contacted with metal catalysts deposited on a support material. The metal catalysts are preferably nanoparticles having diameters less than about 50nm. The reaction temperature is selected such that it is near the eutectic point of the mixture of metal catalyst particles and carbon.

摘要翻译： 提供了用于合成单壁碳纳米管的方法和工艺。 碳前体气体与沉积在载体材料上的金属接触。 金属催化剂优选是直径小于约50nm的纳米粒子。 选择反应温度使其接近金属催化剂颗粒和碳的混合物的共晶点。

公开(公告)号：EP3158098A1

公开(公告)日：2017-04-26

申请号：EP15809942.4

申请日：2015-06-19

申请人： The Ohio State University Research Foundation

发明人： SMITH, Ryan, Thomas ,  LOLLA, Tapasvi ,  BABU, Sudarsanam, Suresh ,  GANDY, David, Wayne ,  SIEFERT, John, Albert ,  GREGORY, J. Frederick ,  LHERBIER, Lou ,  NOVOTNAK, David

IPC分类号： C22C38/00 ,  C22C38/58 ,  B22F7/02 ,  B22F3/15

摘要： A strain-hardenable stainless steel alloy includes hard secondary phases dispersed in an austenitic primary phase, the alloy including 0.3-0.6% nitrogen by weight.

摘要翻译： 应变硬化不锈钢合金包括分散在奥氏体初级相中的硬质次生相，所述合金包含0.3-0.6重量％的氮。

公开(公告)号：EP3138926A3

公开(公告)日：2017-04-05

申请号：EP16184406.3

申请日：2008-09-08

申请人： The Ohio State University Research Foundation

发明人： CROCE, Carlo, M.

IPC分类号： C12Q1/68 ,  A61K31/7088 ,  A61P35/00

CPC分类号： C12Q1/6886 ,  A61K31/7088 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/154 ,  C12Q2600/16 ,  C12Q2600/178

摘要： The present invention provides novel methods for the diagnosis of ovarian cancer using at least one miR selected from miR-200b, miR-141, miR-199a, miR-140, miR-145 and miR-125b1miR-200c. The invention also provides methods of identifying anti-ovarian cancer agents and a kit for detecting ovarian cancer.

摘要翻译： 本发明提供了使用miR-200c诊断卵巢癌的新方法。 本发明还提供鉴定抗癌剂的方法。

公开(公告)号：EP3138926A2

公开(公告)日：2017-03-08

申请号：EP16184406.3

申请日：2008-09-08

申请人： The Ohio State University Research Foundation

发明人： CROCE, Carlo, M.

IPC分类号： C12Q1/68 ,  A61K31/7088 ,  A61P35/00

CPC分类号： C12Q1/6886 ,  A61K31/7088 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/154 ,  C12Q2600/16 ,  C12Q2600/178

摘要： The present invention provides novel methods for the diagnosis of ovarian cancer using at least one miR selected from miR-200b, miR-141, miR-199a, miR-140, miR-145 and miR-125b1miR-200c. The invention also provides methods of identifying anti-ovarian cancer agents and a kit for detecting ovarian cancer.

摘要翻译： 本发明提供了使用选自miR-200b，miR-141，miR-199a，miR-140，miR-145和miR-125b1miR-200c的至少一个miR诊断卵巢癌的新方法。 本发明还提供了鉴定抗卵巢癌药剂和用于检测卵巢癌的药盒的方法。

公开(公告)号：EP3107879A2

公开(公告)日：2016-12-28

申请号：EP15792961.3

申请日：2015-02-18

申请人： The Ohio State University ,  Hyper Tech Research, Inc.

发明人： XU, Xingchen ,  SUMPTION, Michael D. ,  PENG, Xuan

IPC分类号： C04B35/45

CPC分类号： H01B12/10 ,  B22F5/12 ,  B22F7/04 ,  C22C1/0491 ,  C22C32/0031 ,  C22F1/18 ,  H01B13/0016 ,  H01F6/06 ,  H01L39/14 ,  H01L39/2409

摘要： Disclosed herein are superconducting wires. The superconducting wires can comprise a metallic matrix and at least one continuous subelement embedded in the matrix. Each subelement can comprise a non-superconducting core, a superconducting layer coaxially disposed around the non-superconducting core, and a barrier layer coaxially disposed around the super-conducting layer. The superconducting layer can comprise a plurality of Nb3Sn grains stabilized by metal oxide particulates disposed therein. The Nb3Sn grains can have an average grain size of from 5 nm to 90 nm (for example, from 15 nm to 30 nm). The superconducting wire can have a high-field critical current density (Jc) of at least 5,000 A/mm2 at a temperature of 4.2 K in a magnetic field of 12 T. Also described are superconducting 4 wire precursors that can be heat treated to prepare super-conducting wires, as well as methods of making super-conducting wires.

摘要翻译： 这里公开了超导线。 超导线可以包括金属基体和嵌入基质中的至少一个连续子元件。 每个子元件可以包括非超导芯，同轴地设置在非超导芯周围的超导层，以及围绕超导层同轴设置的阻挡层。 超导层可以包括由设置在其中的金属氧化物颗粒稳定的多个Nb 3 Sn颗粒。 Nb 3 Sn粒子的平均粒径可以为5nm〜90nm（例如15nm〜30nm）。 在12T的磁场中，超导线可以在4.2K的温度下具有至少5,000A / mm 2的高场临界电流密度（Jc）。还描述了可以热处理以制备的超导4线前体 超导线，以及制造超导线的方法。

公开(公告)号：EP2637673B1

公开(公告)日：2016-10-26

申请号：EP11840508.3

申请日：2011-11-11

申请人： The Ohio State University Research Foundation

发明人： CROCE, Carlo, M. ,  VALERI, Nicola

IPC分类号： G01N33/574 ,  C12N15/113 ,  A61K31/7105 ,  A61K31/513

CPC分类号： C12N15/1135 ,  A61K31/513 ,  A61K31/7088 ,  A61K31/713 ,  C12N15/113 ,  C12Q1/6886 ,  C12Q2600/112 ,  G01N33/57419 ,  G01N2800/52 ,  G01N2800/56 ,  A61K2300/00