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公开(公告)号：EP1089714A2
公开(公告)日：2001-04-11
申请号：EP99930387.8
申请日：1999-06-18
申请人： RTP Pharma Inc.
发明人： PACE, Gary, W. , VACHON, G., Michael , MISHRA, K., Awadhesh , HENRIKSEN, Inge, B. , KRUKONIS, Val , GODINAS, Anthony
CPC分类号： A61K9/1688 , A61K9/10 , A61K9/14 , A61K9/145 , A61K9/146 , B01F3/1214 , B01F5/0287 , B01F2003/0064 , B01F2003/125 , B01F2215/0032 , B01J3/008 , Y10S977/773 , Y10S977/801 , Y10S977/906
摘要： Submicron particles of water-insoluble compounds, particularly drugs, are prepared by simultaneously stabilizing microparticulate suspensions of same with surface modifier molecules by rapid expansion into an aqueous medium from a compressed solution of the compound and surface modifiers in a liquefied gas and optionally homogenizing the aqueous suspension thus formed with a high pressure homogenizer.
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公开(公告)号：EP0627910B1
公开(公告)日：1997-10-01
申请号：EP93906094.3
申请日：1993-02-19
CPC分类号： B01F3/068 , A61K9/0073 , A61K9/12 , A61K9/124 , A61K9/1688 , A61M15/00 , B01F3/0092 , B01F3/06 , B01F5/02 , B01F5/0287 , B01F2003/0064 , B01F2003/061 , B01F2215/0032 , B01J3/008 , B05B7/32 , B05D1/025 , B05D2401/90 , Y02P20/544
摘要： Methods and apparatus for delivering physiologically active compounds to a target human or animal employ a supercritical fluid solution comprising a supercritical fluid solvent and a physiologically active solute. The supercritical fluid solution is passed into a subcritical region to evaporate the solvent and form a gas-borne dispersion of solute particles. The gas-borne dispersion of solute particles is administered directly to the target human or animal. The apparatus for delivering the physiologically active compound are of the hand-held type.
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公开(公告)号：EP0627910A1
公开(公告)日：1994-12-14
申请号：EP93906094.0
申请日：1993-02-19
CPC分类号： B01F3/068 , A61K9/0073 , A61K9/12 , A61K9/124 , A61K9/1688 , A61M15/00 , B01F3/0092 , B01F3/06 , B01F5/02 , B01F5/0287 , B01F2003/0064 , B01F2003/061 , B01F2215/0032 , B01J3/008 , B05B7/32 , B05D1/025 , B05D2401/90 , Y02P20/544
摘要： L'invention concerne des procédés et des appareils d'administration de composés physiologiquement actifs à un être humain ou à un animal cible, qui utilise une solution liquide supercritique contenant un solvant liquide supercritique et un soluté physiologiquement actif. On fait passer ladite solution supercritique dans une zone sous-critique afin d'entraîner l'évaporation du solvant et une dispersion des particules du soluté dans du gaz. La dispersion dans du gaz des particules du soluté est administrée directement à l'être humain ou à l'animal cible. Les appareils d'administration du composé physiologiquement actif tiennent dans la main.
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14.发明授权PROCESS FOR THE MANUFACTURE OF (SUB)MICRON SIZED PARTICLES BY DISSOLVING IN COMPRESSED GAS AND SURFACTANTS 有权过程不到大测微颗粒的制备爆破成气体压力和表面活性物质
公开(公告)号：EP1071402B1
公开(公告)日：2006-09-13
申请号：EP99919195.0
申请日：1999-04-06
发明人： BAUSCH, Alexander , HIDBER, Pirmin
CPC分类号： B01F3/1214 , A61K9/14 , A61K9/145 , A61K9/1688 , B01F3/1271 , B01F5/0287 , B01F2003/0064 , B01F2003/125 , B01F2215/0032 , B01J2/04 , B01J3/008 , B01J13/02 , Y02P20/544 , Y10S977/906
摘要： The present invention relates to a process for manufacturing a pulverous preparation of a (sub)micron-sized biologically active compound comprising the steps of: (1) dissolving a biologically active compound under elevated pressure in a compressed gas, liquid or supercritical fluid containing a surface modifier; or in compressed dimethylether optionally containing a surface modifier; (2a) rapidly expanding the compressed solution of step (1) thereby precipitating the dissolved compound; or (2b) spraying the compressed solution of step (1) into an antisolvant phase optionally containing a surface modifier under vacuum, atmospheric pressure or elevated pressure; and (3) optionally converting the antisolvant phase of step (2b) into a pulverous preparation using conventional powder processing techniques. With the process according to the present invention formation of aggregations or flocculations of particles dissolved in the supercritical solution is prevented; moreover, the addition of cosolvents is not required, thus increasing the stabilisation of the suspension on an industrial scale.
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公开(公告)号：EP1413351A4
公开(公告)日：2005-11-09
申请号：EP02733498
申请日：2002-06-13
申请人： KARASAWA FINE CO LTD
发明人： KARASAWA YUKIHIKO
CPC分类号： B02C19/065 , B01F3/0807 , B01F3/12 , B01F5/0256 , B01F5/0268 , B01F5/0275 , B01F5/0287 , B01F2003/1257
摘要： A particle pulverizer capable of suppressing the wear of parts, comprising two flow passages (8a) and (8a) positioned on an approximately same straight line and having outlets disposed so as to be close and opposed to each other and through-holes (9) and (9) provided at any positions of the flow passages and having diameters smaller than the diameters of the flow passages, wherein liquid injected from one through-hole (9) does not reach the other through-hole (9).
摘要翻译： 本发明公开了一种能够抑制部件磨损的颗粒粉碎机，包括位于近似相同的直线上且具有设置成彼此靠近且彼此相对的出口的两个流动通道（8a）和（8a）以及通孔（9） 和（9）设置在流路的任何位置处，并且其直径小于流动通道的直径，其中从一个通孔（9）注入的液体不会到达另一个通孔（9）。
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公开(公告)号：EP1413351A1
公开(公告)日：2004-04-28
申请号：EP02733498.6
申请日：2002-06-13
发明人： KARASAWA, Yukihiko
CPC分类号： B02C19/065 , B01F3/0807 , B01F3/12 , B01F5/0256 , B01F5/0268 , B01F5/0275 , B01F5/0287 , B01F2003/1257
摘要： To provide a particle pulverizer capable of suppressing the wear of parts. The particle pulverizer comprises: two flow passages 8a, 8a positioned on an approximately same straight line and having outlets disposed so as to be close and opposed to each other; through-holes 9, 9 provided at any positions of passages and having diameters smaller than the diameters of the flow passages, wherein liquid jetted out of one through-hole 9 does not reach the other through-hole 9.
摘要翻译： 提供一种能够抑制零件磨损的颗粒粉碎机。 颗粒粉碎机包括：两个流动通道8a，8a，它们位于近似相同的直线上并具有设置成彼此靠近和相对的出口; 设置在通路的任意位置且直径比流路的直径小的贯通孔9,9，从一个贯通孔9喷出的液体不会到达另一个贯通孔9。
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公开(公告)号：EP0855906A1
公开(公告)日：1998-08-05
申请号：EP96936782.0
申请日：1996-10-17
发明人： HENRIKSEN, Inge, B. , MISHRA, Awadesh, K. , PACE, Gary, W. , JOHNSTON, Keith, P. , MAWSON, Simon
CPC分类号： B01J3/008 , A61K9/14 , A61K9/145 , A61K9/146 , A61K9/1688 , B01F1/00 , B01F3/1214 , B01F3/1271 , B01F5/02 , B01F5/0287 , B01F2003/0064 , B01F2003/125 , B01F2215/0032 , Y02P20/544 , Y10S977/896 , Y10S977/906
摘要： Particles of water insoluble biologically active compounds, particularly water-insoluble drugs, with an average size of 100 nm to about 300 nm, are prepared by dissolving the compound in a solution then spraying the solution into compressed gaz, liquid or supercritical fluid in the presence of appropriate surface modifiers.
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18.发明公开Methods and apparatus for fine particle formation 失效Verfahren und Apparat zur Erzeugung von feinen Partikeln。
公开(公告)号：EP0677332A2
公开(公告)日：1995-10-18
申请号：EP95302078.1
申请日：1995-03-29
申请人： Sievers, Robert, E.
发明人： Sievers, Robert E , Karst, Uwe
IPC分类号： B05B7/24
CPC分类号： A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/12 , A61K9/124 , A61K9/1688 , A61M15/00 , B01F3/0092 , B01F3/06 , B01F3/068 , B01F5/02 , B01F5/0287 , B01F2003/0064 , B01F2003/061 , B01F2215/0032 , B01J2/04 , B01J3/008 , B05B7/32 , B05B12/1418 , B05D1/025 , B05D2401/90 , Y02P20/544
摘要： Methods and apparatuses are provided for forming fine particles of a desired substance comprising dissolving said substance in a fluid such as water to form a solution and mixing the solution with a second fluid such as supercritical carbon dioxide which becomes a gas upon rapid pressure release, and with which the first fluid is at least partially immiscible, and releasing the pressure to form an air-borne dispersion or aerosol comprising particles having an average diameter between about 0.1 and about 6.5 µm.
摘要翻译： 提供了用于形成所需物质的细颗粒的方法和装置，包括将所述物质溶解在诸如水的流体中以形成溶液并将该溶液与快速释放时成为气体的第二流体例如超临界二氧化碳混合，以及 其中第一流体至少部分地不混溶，并且释放压力以形成包含平均直径在约0.1至约6.5μm之间的颗粒的空气传播分散体或气溶胶。
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