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公开(公告)号：EP3341476A1
公开(公告)日：2018-07-04
申请号：EP16763598.6
申请日：2016-08-24
申请人： Ajinomoto Co., Inc. , Evolva SA
发明人： SCHWAB, Markus , BABAU, Maud , FISCHER, David , HATSCH, Anaelle , TAVARES, Sabina de Andrade Pereira , NIELSEN, Curt Aime Friis , KLEIN, Jens , WIRDNAM, Corina Daniela
CPC分类号： C12P13/001 , C07C215/10 , C07F9/09 , C12N1/16 , C12N9/12 , C12N9/1205 , C12P1/02 , C12P7/6481 , C12Y207/01091 , C12Y207/11001
摘要： A method for producing an objective substance such as phytosphingosine and sphinganine using yeast is provided. An objective substance is produced by cultivating yeast having an ability to produce the objective substance and modified so that the expression and/or activities of proteins encoded by LCB4 and CKA2 genes are reduced in a culture medium, and collecting the objective substance from cells of the yeast and/or the culture medium.
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12.发明公开MODULATION OF EGFR SIGNALLING BY MODULATION OF SPHINGOSINE KINASE SIGNALLING 审中-公开EGFR信号由穿梭鞘氨醇信号传导的调节
公开(公告)号：EP1910523A4
公开(公告)日：2009-05-27
申请号：EP06752619
申请日：2006-06-21
发明人： XIA PU , SUKOCHEVA OLGA , VADAS MATHEW ALEXANDER
CPC分类号： C12N15/1137 , A61K48/00 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/3517 , C12Y207/01091
摘要： The present invention relates generally to a method of modulating EGFR-mediated cellular functional activity and agents useful for same. More particularly, the present invention relates to a method of modulating agonist induced EGFR-mediated cellular proliferation by modulating upstream intracellular sphingosine kinase signalling. The method of the invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant EGFR-mediated cellular functioning, in particular aberrant EGFR-mediated cellular proliferation.
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公开(公告)号：EP1910525A1
公开(公告)日：2008-04-16
申请号：EP06752621.0
申请日：2006-06-21
CPC分类号： C12N9/1205 , A61K48/00 , C12Y207/01091
摘要： The present invention relates generally to a method of modulating cellular activity and to agents for use therein. More particularly, the present invention provides a method of modulating the level of sphingosine kinase functional activity. In a related aspect, the present invention provides a method of modulating sphingosine kinase mediated signalling via modulation of its intracellular level of activity. The present invention still further extends to novel molecules which exhibit the capacity to induce sphingosine kinase activity. The methods and molecules of the present invention are useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate cellular functional activity and/or aberrant, unwanted or otherwise inappropriate sphingosine kinase mediated signalling. The present invention is further directed to methods for identifying and/or designing agents capable of modulating the level of sphingosine kinase activity.
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公开(公告)号：EP1910524A1
公开(公告)日：2008-04-16
申请号：EP06752620.2
申请日：2006-06-21
CPC分类号： C12Y207/01091 , A61K48/00 , C12N9/1205
摘要： The present invention relates generally to a method of modulating cellular activity and to agents for use therein. More particularly, the present invention provides a method of modulating the level of sphingosine kinase functional activity. In a related aspect, the present invention provides a method of modulating sphingosine kinase mediated signalling via modulation of its intracellular level of activity. The present invention still further extends to novel molecules which exhibit the capacity to induce sphingosine kinase activity. The methods and molecules of the present invention are useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate cellular functional activity and/or aberrant, unwanted or otherwise inappropriate sphingosine kinase mediated signalling. The present invention is further directed to methods for identifying and/or designing agents capable of modulating the level of sphingosine kinase activity.
摘要翻译： 本发明一般涉及调节细胞活性的方法和用于其中的试剂。 更具体地说，本发明提供了调节鞘氨醇激酶功能活性水平的方法。 在相关方面，本发明提供了通过调节其胞内活性水平来调节鞘氨醇激酶介导的信号传导的方法。 本发明还进一步扩展到表现出诱导鞘氨醇激酶活性的能力的新型分子。 本发明的方法和分子尤其可用于治疗和/或预防以异常的，不需要的或其他不适当的细胞功能活性和/或异常的，不需要的或其他不适当的鞘氨醇激酶介导的信号传导为特征的病症。 本发明还涉及鉴定和/或设计能够调节鞘氨醇激酶活性水平的药剂的方法。
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