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公开(公告)号：EP1845971A4
公开(公告)日：2009-12-30
申请号：EP06700570
申请日：2006-01-17
发明人： XIA PU , WANG LIJUN , VADAS MATHEW ALEXANDER
IPC分类号： A61K31/352 , A61K31/133 , A61K31/277 , A61P9/10 , A61P9/14
CPC分类号： A61K31/133 , A61K31/277 , A61K31/352 , C12Y207/01091
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公开(公告)号：EP1299548A1
公开(公告)日：2003-04-09
申请号：EP01942904.2
申请日：2001-06-20
发明人： PITSON, Stuart , MORETTI, Paul , XIA, Pu , VADAS, Matthew , WATTENBERG, Binks
CPC分类号： C12N9/1205 , A61K38/00 , C12Y207/01091 , G01N2333/91205 , G01N2500/02 , G01N2500/04
摘要： The present invention relates generally to a sphingosine kinase variant and to derivatives, analogues, chemical equivalents and mimetics thereof exhibiting reduced catalytic activity and, more particularly, to sphingosine kinase variants which exhibit a reduced capacity to phosphorylate sphingosine to sphingosine-1-phosphate. The present invention also contemplates genetic sequences encoding said sphingosine kinase variants and derivatives, analogues and mimetics thereof. The variants of the present invention are useful in a range of therapeutic and prophylactic applications.
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公开(公告)号：EP3341488A1
公开(公告)日：2018-07-04
申请号：EP16763597.8
申请日：2016-08-24
申请人： Ajinomoto Co., Inc. , Evolva SA
发明人： SCHWAB, Markus , WIRDNAM, Corina Daniela , TANGE, Thomas Oestergaard , BABAU, Maud , HATSCH, Anaelle , DELEGRANGE, Fanny , FISCHER, David , TAVARES, Sabina de Andrade Pereira
IPC分类号： C12P13/02
CPC分类号： C12P13/02 , C12N2500/05 , C12N2500/30 , C12P13/001 , C12Y101/01102 , C12Y114/13169 , C12Y114/18 , C12Y203/01 , C12Y203/01024 , C12Y203/0105 , C12Y203/01199 , C12Y204/0108 , C12Y207/01091 , C12Y207/11001 , C12Y305/01023 , C12Y403/01017
摘要： A method for producing an objective substance such as sphingoid bases and sphingolipids using yeast is provided. An objective substance is produced by cultivating yeast having an ability to produce the objective substance in a culture medium containing an additive that is able to associate with, bind to, solubilize, and/or capture the objective substance, and collecting the objective substance from cells of the yeast and/or the culture medium.
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公开(公告)号：EP2744896B1
公开(公告)日：2016-03-16
申请号：EP12738448.5
申请日：2012-07-23
申请人： Evonik Degussa GmbH
发明人： KÖHLER, Tim , SCHORSCH, Christoph , BOLES, Eckhard , ANDREA, Heiko , FARWICK, Mike , SCHAFFER, Steffen
CPC分类号： C12P13/02 , C07K14/39 , C12N9/0006 , C12N9/0073 , C12N9/1014 , C12N9/1029 , C12N9/1205 , C12N9/88 , C12N15/815 , C12P7/6436 , C12Y114/13169 , C12Y203/0105 , C12Y207/01091 , C12Y401/02027 , Y02P20/52
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公开(公告)号：EP2744896A1
公开(公告)日：2014-06-25
申请号：EP12738448.5
申请日：2012-07-23
申请人： Evonik Degussa GmbH
发明人： KÖHLER, Tim , SCHORSCH, Christoph , BOLES, Eckhard , ANDREA, Heiko , FARWICK, Mike , SCHAFFER, Steffen
CPC分类号： C12P13/02 , C07K14/39 , C12N9/0006 , C12N9/0073 , C12N9/1014 , C12N9/1029 , C12N9/1205 , C12N9/88 , C12N15/815 , C12P7/6436 , C12Y114/13169 , C12Y203/0105 , C12Y207/01091 , C12Y401/02027 , Y02P20/52
摘要： The invention relates to Pichia ciferrii cells modified by genetic engineering, to the use thereof, and to a method for producing sphingoid bases and sphingolipids.
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公开(公告)号：EP1845971A1
公开(公告)日：2007-10-24
申请号：EP06700570.2
申请日：2006-01-17
发明人： XIA, Pu , WANG, Lijun , VADAS, Mathew, Alexander
IPC分类号： A61K31/352 , A61K31/277 , A61P9/14 , A61K31/133 , A61P9/10
CPC分类号： A61K31/133 , A61K31/277 , A61K31/352 , C12Y207/01091
摘要： The present invention relates generally to a method of modulating hyperglycaemia-induced endothelial cell functioning and agents useful for same. More particularly, the present invention relates to a method of modulating hyperglycaemia-induced vascular endothelial cell functioning by modulating intracellular sphingosine kinase-mediated signalling. The method of the present invention is useful, inter alia, in the treatment and/or prophylaxis of the adverse vascular endothelial cell functioning associated with conditions characterised by hyperglycaemia, and/or diabetes mellitus, per se.
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公开(公告)号：EP1299548A4
公开(公告)日：2004-12-01
申请号：EP01942904
申请日：2001-06-20
发明人： PITSON STUART , MORETTI PAUL , XIA PU , VADAS MATTHEW , WATTENBERG BINKS
IPC分类号： C12N15/09 , A61K38/43 , A61K38/48 , A61P1/04 , A61P7/00 , A61P9/10 , A61P11/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P35/00 , A61P43/00 , C12N9/12 , C12N15/54 , C12Q1/02 , C12Q1/48 , A61K38/45 , G01N33/68
CPC分类号： C12N9/1205 , A61K38/00 , C12Y207/01091 , G01N2333/91205 , G01N2500/02 , G01N2500/04
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公开(公告)号：EP1910525A4
公开(公告)日：2009-05-06
申请号：EP06752621
申请日：2006-06-21
CPC分类号： C12N9/1205 , A61K48/00 , C12Y207/01091
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公开(公告)号：EP1910524A4
公开(公告)日：2009-04-01
申请号：EP06752620
申请日：2006-06-21
CPC分类号： C12Y207/01091 , A61K48/00 , C12N9/1205
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10.发明公开MODULATION OF EGFR SIGNALLING BY MODULATION OF SPHINGOSINE KINASE SIGNALLING 审中-公开EGFR信号由穿梭鞘氨醇信号传导的调节
公开(公告)号：EP1910523A1
公开(公告)日：2008-04-16
申请号：EP06752619.4
申请日：2006-06-21
CPC分类号： C12N15/1137 , A61K48/00 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/3517 , C12Y207/01091
摘要： The present invention relates generally to a method of modulating EGFR-mediated cellular functional activity and agents useful for same. More particularly, the present invention relates to a method of modulating agonist induced EGFR-mediated cellular proliferation by modulating upstream intracellular sphingosine kinase signalling. The method of the invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant EGFR-mediated cellular functioning, in particular aberrant EGFR-mediated cellular proliferation.
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