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    SALACIA COMPOSITIONS, METHODS OF TREATMENT BY THEIR ADMINISTRATION, AND METHODS OF THEIR PREPARATION
    11.
    发明公开
    SALACIA COMPOSITIONS, METHODS OF TREATMENT BY THEIR ADMINISTRATION, AND METHODS OF THEIR PREPARATION 审中-公开
    SALACIA-ZUSAMMENSETZUNGEN，BEHANDLUNGSVERFAHREN MITTELS VERABREICHUNG DAVON UND VERFAHREN ZU DEREN HERSTELLUNG

    公开(公告)号：EP3071214A4

    公开(公告)日：2017-09-06

    申请号：EP14864855

    申请日：2014-11-19

    申请人： OMNIACTIVE HEALTH TECH (CANADA) LTD

    发明人： DESHPANDE JAYANT ,  GHANAM KHADIJA ,  EWART STEPHEN ,  JUTURU VIJAYA

    IPC分类号： A61K36/37 ,  A61K31/352 ,  A61K31/575 ,  A61P3/04 ,  C07H7/04 ,  C07J71/00 ,  C12N9/04 ,  C12N9/16

    CPC分类号： A61K36/37 ,  A23L33/10 ,  A23L33/105 ,  A61K31/122 ,  A61K31/192 ,  A61K31/7048

    摘要： A Salacia composition described herein significantly reduces appetite, activates Hormone Sensitive Lipase, and manages a healthy lipid profile through inhibition of HMG-CoA Reductase enzyme. Salacia compositions described herein include of at least 12% of polyphenols, 2% of mangiferin and 1% of 25,26-oxidofriedelane-1,3-dione by weight of the composition in the form of extract. The composition is obtained by continuous solvent extraction, employing non-aqueous food grade solvents. Salacia compositions herein reduce appetite by about 18% of routine diet, when effective amounts are administered to a subject in need thereof. Effective management of a healthy lipid profile is thus possible with synergistic combination of reduction in energy intake, activation of Hormone Sensitive Lipase, and inhibition of HMG-CoA Reductase enzyme responsible for cholesterol metabolism.

    摘要翻译： 本文所述的五层龙组合物显着降低食欲，激活激素敏感性脂肪酶，并通过抑制HMG-CoA还原酶来管理健康的脂质特征。 本文所述的沙拉西亚组合物包含按提取物形式的组合物的重量计至少12％的多酚，2％的芒果苷和1％的25,26-氧化十三烯-1,3-二酮。 该组合物通过使用非水性食品级溶剂的连续溶剂萃取而获得。 当将有效量给予有需要的受试者时，本文中的Salacia组合物减少约18％常规饮食的食欲。 因此，通过协同减少能量摄入，激活激素敏感性脂肪酶和抑制负责胆固醇代谢的HMG-CoA还原酶，可以有效管理健康的血脂谱。

    SALACIA COMPOSITIONS, METHODS OF TREATMENT BY THEIR ADMINISTRATION, AND METHODS OF THEIR PREPARATION
    12.
    发明公开
    SALACIA COMPOSITIONS, METHODS OF TREATMENT BY THEIR ADMINISTRATION, AND METHODS OF THEIR PREPARATION 审中-公开
    五层组合物，处理情况其施用方法和方法及其

    公开(公告)号：EP3071214A1

    公开(公告)日：2016-09-28

    申请号：EP14864855.3

    申请日：2014-11-19

    申请人： Omniactive Health Technologies (Canada) Limited

    发明人： DESHPANDE, Jayant ,  GHANAM, Khadija ,  EWART, Stephen ,  JUTURU, Vijaya

    IPC分类号： A61K36/37 ,  A61K31/352 ,  A61K31/575 ,  A61P3/04 ,  C07H7/04 ,  C07J71/00 ,  C12N9/04 ,  C12N9/16

    CPC分类号： A61K36/37 ,  A23L33/10 ,  A23L33/105 ,  A61K31/122 ,  A61K31/192 ,  A61K31/7048

    摘要： A Salacia composition described herein significantly reduces appetite, activates Hormone Sensitive Lipase, and manages a healthy lipid profile through inhibition of HMG-CoA Reductase enzyme. Salacia compositions described herein include of at least 12% of polyphenols, 2% of mangiferin and 1% of 25,26-oxidofriedelane-1,3-dione by weight of the composition in the form of extract. The composition is obtained by continuous solvent extraction, employing non-aqueous food grade solvents. Salacia compositions herein reduce appetite by about 18% of routine diet, when effective amounts are administered to a subject in need thereof. Effective management of a healthy lipid profile is thus possible with synergistic combination of reduction in energy intake, activation of Hormone Sensitive Lipase, and inhibition of HMG-CoA Reductase enzyme responsible for cholesterol metabolism.

    摘要翻译： 中记载的组合物，五层龙极大减少食欲，所述激活激素敏感脂肪酶，并管理通过抑制HMG-CoA还原酶酶的健康脂质谱。 在描述的五层龙的组合物包括的多酚的至少12％，芒果苷的2％和按重量计在提取物的形式该组合物中的25,26-oxidofriedelane -1,3-二酮1％。 该组合物通过连续溶剂萃取获得，使用非水性食品级溶剂。 五层龙的组合物通过常规的饮食，当有效量施用给需要其的受试者的约18％降低食欲。 一个健康的脂质分布的有效管理是可能的减少的能量摄入，激素敏感脂肪酶的活化，以及抑制负责胆固醇代谢的HMG-CoA还原酶的。因此协同组合。