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    ANTIOXIDANT POLYMERS CONTAINING [1,2]-DITHIOLANE MOIETIES AND USES THEREOF
    13.
    发明公开
    ANTIOXIDANT POLYMERS CONTAINING [1,2]-DITHIOLANE MOIETIES AND USES THEREOF 审中-公开
    含有[1,2] - 二十四烷结构的抗氧化剂聚合物及其用途

    公开(公告)号：EP2125775A1

    公开(公告)日：2009-12-02

    申请号：EP08731097.5

    申请日：2008-02-29

    申请人： Cedars-Sinai Medical Center

    发明人： YU, John, S. ,  LEE, Bong Seop

    IPC分类号： C07D339/02 ,  C07D341/00 ,  A61K31/385

    CPC分类号： C07D339/04 ,  C08B37/003

    摘要： The present invention describes polymers containing 1,2-dithiolanes capable of acting as scavengers of free radicals, metals and reactive oxygen species. Also described are methods of synthesizing the antioxidant 1,2-dithiolane derivatives and polymerization thereof to produce biodegradable antioxidant polymers. The antioxidant polymers of the present invention may be used to treat diseases or conditions caused by oxidative stress and other free radical mediated conditions. The antioxidant polymers may also be used for the preparation of antioxidant particulate delivery devices of therapeutic agents.

    摘要翻译： 本发明描述了含有能够充当自由基清除剂，金属和活性氧物质的1,2-二硫戊环的聚合物。 还描述了合成抗氧化剂1,2-二硫戊环衍生物及其聚合以生产可生物降解的抗氧化剂聚合物的方法。 本发明的抗氧化聚合物可用于治疗由氧化应激和其他自由基介导的病症引起的疾病或病症。 抗氧化剂聚合物也可以用于制备治疗剂的抗氧化剂颗粒递送装置。

    METHODS AND COMPOUNDS USEFUL IN INHIBITING OXIDATIVE AND/OR FREE RADICAL DAMAGE AND IN THE TREATMENT AND PREVENTION OF DISEASE
    14.
    发明公开
    METHODS AND COMPOUNDS USEFUL IN INHIBITING OXIDATIVE AND/OR FREE RADICAL DAMAGE AND IN THE TREATMENT AND PREVENTION OF DISEASE 审中-公开
    的氧化损坏的抑制和/或损害的方法和化合物自由基以及用于治疗和预防疾病都适合

    公开(公告)号：EP1476440A2

    公开(公告)日：2004-11-17

    申请号：EP03716163.5

    申请日：2003-02-24

    申请人： Albany College of Pharmacy

    发明人： LEVIN, Robert, M. ,  HASS, Martha, A.

    IPC分类号： C07D339/02 ,  A61K31/385

    CPC分类号： C07D409/12

    摘要： Disclosed are methods for treating obstructive and ischemic bladder diseases which include administering a compound which includes a cyclic or acyclic disulfide covalently bonded to a lipid-soluble antioxidant or which include administering a reduced sulfhydryl derivative thereof. Also disclosed are compounds that include a benzopyran moiety which is directly or indirectly covalently bonded to a cyclic or acyclic disulfide, as well as reduced sulfhydryl derivatives of such compounds. Methods for making such compounds and reduced sulfhydryl derivatives using tocopherol and lipoic acid starting materials are also disclosed, as are methods for inhibiting oxidative and/or free radical damage in a subject's cells, nerve membranes, sarcoplasmic reticula, mitochondrial membranes, and/or muscle plasma membranes and methods for treating and/or preventing obstructive and ischemic bladder diseases, conditions involving hypoxia, ischemia, and/or reoxygenation injury.