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    LIPOIC ACID ANALOGS
    5.
    发明公开
    LIPOIC ACID ANALOGS 审中-公开
    硫酸类似物

    公开(公告)号：EP1061914A1

    公开(公告)日：2000-12-27

    申请号：EP99912301.1

    申请日：1999-03-05

    申请人： REGENTS OF THE UNIVERSITY OF CALIFORNIA

    发明人： PACKER, LesterDept. of Molecular & Cell Biology ,  TIROSH, OrenDept. of Molecular & Cell Biology ,  SEN, Chandan, K.Dept. of Molecular & Cell Biology ,  ROY, SashwatiDept. of Molecular & Cell Biology

    IPC分类号： A61K31/385 ,  C07D339/02

    CPC分类号： C07D339/04

    摘要： A compound is provided having formula (I) wherein R?1 and R2¿ independently denote a methylene, ethylene or unbranched or branched C¿3-16? alkylene, alkenylene or alkynylene group which is unsubstituted or substituted with one or more halogen, hydroxyl or amine groups, wherein in the unbranched or branched C3-16 alkylene, alkenylene or alkynylene group an internal alkylene carbon atom in the carbon backbone thereof can be replaced by an oxygen atom, R?3 and R4¿ (i) independently denote (a) hydrogen, (b) a methyl, ethyl, vinyl or unbranched or branched C¿3-16? alkyl, alkenyl or alkynyl group which is unsubstituted or substituted with one or more halogen, hydroxyl or amine groups, wherein in said unbranched or branched C3-16 alkyl, alkenyl or alkynyl group an internal alkylene carbon atom in the carbon backbone thereof can be replaced by an oxygen atom, (c) a cycloalkyl, alkylcycloalkyl, alkynylcycloalkyl or alkynylcycloalkyl group having 5 to 16 carbon atoms which is unsubstituted or substituted with one or more halogen, hydroxyl or amine groups, or (d) an aryl, alkaryl, aralkyl, alkenylaryl, aralkenyl, alkynylaryl or aralkynyl group having 6 to 16 carbon atoms which is unsubstituted or substituted with one or more halogen, hydroxyl or amine groups, or (ii) jointly with the nitrogen atom form a cyclic or aromatic amine which is unsubstituted or substituted with one or more alkyl, alkenyl, alkynyl, halogen, hydroxyl or amine groups, X denotes O, S, -NH- or -NR?5¿-, and R5 denotes methyl, ethyl, or unbranched or branched C¿3-16? alkyl, or a pharmaceutically acceptable salt thereof, wherein t he compound is in equilibrium at physiological pH with a protonated form thereof. Methods of making the compounds, compositions including the compounds and methods of treatment of conditions involving reactive oxygen species are also provided.

    摘要翻译： 提供具有式（I）的化合物，其中R 1和R 2独立地表示亚甲基，亚乙基或未分支或分支的C 3-16 - 亚烷基，亚烯基或亚炔基，其未被取代或被一个或多个卤素，羟基或胺基取代，其中在未支化或支化的C3-16亚烷基，亚烯基或亚炔基中，其碳主链中的内亚烷基碳原子可被取代 （i）独立地表示（a）氢，（b）甲基，乙基，乙烯基或直链或支链的C 3-16烯基， 烷基，烯基或炔基，其未被取代或被一个或多个卤素，羟基或胺基取代，其中在所述未支化或支化的C 3-16烷基，烯基或炔基中，其碳主链中的内部亚烷基碳原子可被取代 （c）未取代或被一个或多个卤素，羟基或胺基取代的具有5至16个碳原子的环烷基，烷基环烷基，炔基环烷基或炔基环烷基，或（d）芳基，烷芳基，芳烷基， 具有6-16个碳原子的未取代或被一个或多个卤素，羟基或胺基团取代的烯基芳基，芳烯基，炔基芳基或芳炔基，或（ii）与氮原子一起形成未取代或取代的环状或芳族胺 与一个或多个烷基，烯基，炔基，卤素，羟基或胺基团相连，X表示O，S，-NH-或-NR 5+，并且R 5表示甲基，乙基或直链或支链C 3-16 ？ 烷基或其药学上可接受的盐，其中化合物在生理pH下与其质子化形式处于平衡。 还提供了制备所述化合物的方法，包含所述化合物的组合物以及涉及活性氧种类的治疗方法。

    Use of polymer material containing ultraviolet absorbent
    8.
    发明授权
    Use of polymer material containing ultraviolet absorbent 有权
    使用的聚合物材料的与UV吸收剂

    公开(公告)号：EP2113536B1

    公开(公告)日：2012-07-04

    申请号：EP08720776.7

    申请日：2008-02-20

    申请人： FUJIFILM Corporation

    发明人： YAWATA, Toshihiko ,  HANAKI, Naoyuki ,  MIKOSHIBA, Hisashi ,  KANEKO, Akihiro

    IPC分类号： C08L101/00 ,  C08K5/45 ,  C09K3/00 ,  C07D339/02

    CPC分类号： C08K5/45 ,  C07D339/02 ,  C09K15/12

    摘要： Disclosed is a polymer material obtained by having at least one polymer selected from the group consisting of acrylic acid polymers, polyester polymers and polycarbonate polymers contain a compound represented by the following general formula (2). (In the formula, A21 and A22 represent an atom other than a hydrogen atom or a carbon atom; Y21 and Y22 independently represent a hydrogen atom or a monovalent substituent, provided that at least one of Y21 and Y22 represents a substituent having a Hammett substituent constant σp of not less than 0.2, or alternatively Y21 and Y22 may combine together to form a ring; and (B) represents an atomic group necessary for forming a five-membered or six-membered ring together with A21, A22 and a carbon atom.)