公开(公告)号：EP3620517A3

公开(公告)日：2020-07-29

申请号：EP19201640.0

申请日：2015-07-10

申请人： Corbion Biotech, Inc.

发明人： DAVIS, David ,  RUDENKO, George ,  SOMANCHI, Aravind ,  CASOLARI, Jason ,  FRANKLIN, Scott ,  EWING, Aren

IPC分类号： C12N9/10 ,  C12P7/64 ,  C12R1/89 ,  C12P33/00

摘要： The present invention relates to beta-ketoacyl ACP synthase genes of the KASI/KASIV type and proteins encoded by these genes. The genes can be included in nucleic acid constructs, vectors or host cells. Expression of the gene products can alter the fatty acid profile of host cells. The KAS genes can be combined with a FATA or FATB thioesterase gene to create a cell that produces an increased amount of C8-C16 fatty acids. Suitable host cells include plastidic cells of plants or microalgae. Oleaginous microalga host cells with the new genes are disclosed

公开(公告)号：EP3180424B1

公开(公告)日：2020-03-18

申请号：EP15750704.7

申请日：2015-08-12

申请人： PharmaZell GmbH

发明人： HUMMEL, Werner ,  BAKONYI, Daniel

IPC分类号： C12N9/04 ,  C12P33/02

公开(公告)号：EP3569702A1

公开(公告)日：2019-11-20

申请号：EP18203650.9

申请日：2018-10-31

申请人： Intelligent Synthetic Biology Center

发明人： KIM, Sun-Chang ,  LEE, Ju Young ,  KIM, Jae Eung ,  JANG, In Seung ,  JEGAL, Jong Geon

IPC分类号： C12N9/04 ,  C07K14/395 ,  C12N9/02 ,  C12P33/00 ,  C12N1/19

摘要： The present invention relates to yeast with an enhanced ginsenoside-producing ability prepared by changing Ald2, Ald6, Zwf1, and Zms1, a method of preparing the yeast, and a method for producing ginsenosides using the yeast.

公开(公告)号：EP3167053B1

公开(公告)日：2019-10-09

申请号：EP15747630.0

申请日：2015-07-10

申请人： Corbion Biotech, Inc.

发明人： DAVIS, David ,  RUDENKO, George ,  SOMANCHI, Aravind ,  CASOLARI, Jason ,  FRANKLIN, Scott ,  EWING, Aren

IPC分类号： C12N9/10 ,  C12P7/64 ,  C12R1/89 ,  C12P33/00

公开(公告)号：EP2971027B1

公开(公告)日：2019-01-30

申请号：EP14714149.3

申请日：2014-03-14

申请人： Amyris, Inc. ,  Total Marketing Services

发明人： HAWKINS, Kristy Michelle ,  MAHATDEJKUL-MEADOWS, Tina Tipawan ,  MEADOWS, Adam Leon ,  PICKENS, Lauren Barbara ,  TAI, Anna ,  TSONG, Annie Ening

IPC分类号： C12P19/00 ,  C12P23/00 ,  C12P33/00 ,  C12P5/00 ,  C12P7/00 ,  C12P15/00 ,  C12P17/00 ,  C12N9/10 ,  C12N9/16 ,  C12N9/88

公开(公告)号：EP3351640A1

公开(公告)日：2018-07-25

申请号：EP16857826.8

申请日：2016-10-21

申请人： Amorepacific Corporation

发明人： NAM, Gi Baeg ,  KIM, Dong Hyun ,  HONG, Yong Deog ,  ZHANG, Cheng Yi ,  PARK, Jun Seong

IPC分类号： C12P19/44 ,  C12P33/16 ,  C12N9/24 ,  C12N9/42 ,  C07H17/00 ,  C07J17/00

CPC分类号： C12P33/16 ,  C07H17/00 ,  C07J17/00 ,  C12N9/24 ,  C12N9/2437 ,  C12P19/44 ,  C12P33/20 ,  C12Y302/01004 ,  C12Y302/01015 ,  C12Y302/0104

摘要： The present invention relates to a method for selectively producing compound K and compound Y, which are originally present in ginseng in a trace amount, from saponins of ginseng, and more specifically to a method capable of obtaining desired target compounds, that is, compound K and compound Y, in high yields, by treating saponins, obtained from ginseng, with particular enzymes to structurally convert the saponins.

公开(公告)号：EP2998404B1

公开(公告)日：2018-06-27

申请号：EP15185757.0

申请日：2015-09-17

申请人： Korea Advanced Institute of Science and Technology ,  Intelligent Synthetic Biology Center

发明人： KIM, Sun-Chang ,  CHOI, Giltsu ,  JUNG, Suk-Chae ,  KIM, Woohyun ,  LIM, Soohwan ,  IM, Wan-Taek

IPC分类号： C12P33/00 ,  C12P19/56 ,  C12N9/10 ,  A61K31/704

CPC分类号： C12P33/20 ,  C12N9/1051 ,  C12P19/56 ,  C12P33/00 ,  C12Y204/01

摘要： Provided are a novel UDP-glycosyltransferase (uridine diphosphate glycosyltransferase) protein from Dolwoe (Gynostemma pentaphyllum) having glycosyltransfer activity for glucose linked by a glycosidic bond at the C-20 position of PPD (protopanaxadiol)-type or PPT (protopanaxatriol)-type ginsenoside, and use thereof.

公开(公告)号：EP3095874A4

公开(公告)日：2017-08-30

申请号：EP15737840

申请日：2015-01-14

申请人： KYOWA HAKKO BIO CO LTD

发明人： UJIHARA TETSURO ,  MITSUHASHI SATOSHI

IPC分类号： C12P33/00 ,  C07C401/00 ,  C07J9/00

CPC分类号： C07C401/00 ,  C07C2101/14 ,  C07C2102/24 ,  C07C2601/14 ,  C07C2602/24 ,  C07J9/00 ,  C12P33/00

公开(公告)号：EP3201315A2

公开(公告)日：2017-08-09

申请号：EP15797018.7

申请日：2015-09-30

申请人： Evolva SA

发明人： HOUGHTON-LARSEN, Jens ,  KRZYSTANEK, Katarzyna ,  SEMMLER, Angelika ,  HANSEN, Iver Klavs Riishede ,  DAMKIAER, Soren ,  LIU, Gary ,  LIU, Yaoquan ,  HANSEN, Jorgen ,  KUMAR, Sathish ,  MURALI, Muthuswamy Panchapagesa ,  RASMUSSEN, Nina Nicoline

IPC分类号： C12N1/19 ,  C12N9/06 ,  C12N9/90 ,  C12N9/02 ,  C12N9/14 ,  C12N9/10 ,  C12P19/18 ,  C12P19/56 ,  C12P33/00

CPC分类号： C12P33/00 ,  A23L27/36 ,  A23V2002/00 ,  C07H1/06 ,  C12N9/0014 ,  C12N9/0042 ,  C12N9/0071 ,  C12N9/0073 ,  C12N9/1051 ,  C12N9/14 ,  C12N9/90 ,  C12N15/00 ,  C12P19/18 ,  C12P19/56

摘要： Methods for recombinant and enzymatic production of mogroside compounds and compositions containing mogroside compounds are provided by this invention.

摘要翻译： 本发明提供了用于重组和酶促生产罗汉果苷化合物和含有罗汉果苷化合物的组合物的方法。

公开(公告)号：EP3161144A2

公开(公告)日：2017-05-03

申请号：EP15731902.1

申请日：2015-06-24

申请人： PharmaZell GmbH

发明人： WEUSTER-BOTZ, Dirk ,  SUN, Boqiao ,  QUIRIN, Christian

IPC分类号： C12P33/00 ,  C12N9/04

摘要： The invention relates to novel biocatalytic processes, comprising the whole cell reduction of dehydrocholic acid (DHCS) compounds, novel 7ß-hydroxysteroid dehydrogenase mutants, to the sequences encoding said enzyme mutants, to methods for producing the enzyme mutants and to the use thereof in enzymatic conversion of cholic acid compounds, and especially in the production of ursodeoxycholic acid (UDCS); The invention also relates to novel methods for the synthesis of UDCS using the enzyme mutants; and in particular to a further improved method for producing UDCS using recombined whole-cell biocatalysts.

摘要翻译： 本发明涉及新型生物催化方法，包括将脱氢胆酸（DHCS）化合物，新型7β-羟基类固醇脱氢酶突变体全细胞还原为编码所述酶突变体的序列，涉及生产酶突变体的方法及其在酶促 胆酸化合物的转化，尤其是在熊去氧胆酸（UDCS）的生产中; 本发明还涉及使用酶突变体合成UDCS的新方法; 并且具体涉及使用重组全细胞生物催化剂生产UDCS的进一步改进的方法。