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    MICROORGANISMS FOR DITERPENE PRODUCTION
    4.
    发明公开
    MICROORGANISMS FOR DITERPENE PRODUCTION 审中-公开

    公开(公告)号：EP3502264A3

    公开(公告)日：2019-11-06

    申请号：EP19154743.9

    申请日：2014-06-02

    申请人： DSM IP Assets B.V.

    发明人： BOER, Viktor Marius ,  SUIR, Erwin

    IPC分类号： C12P15/00 ,  C12P19/56 ,  C12N9/02 ,  C12N9/10 ,  C12N9/16 ,  C12N9/24 ,  C12N9/88 ,  C12N9/90 ,  C07K14/39 ,  C07K14/395 ,  C12N15/52 ,  A23L2/60 ,  A23L27/30 ,  C07H15/256

    摘要： The present invention relates to a recombinant microorganism comprising one or more nucleotide sequence(s) encoding: a polypeptide having ent-copalyl pyrophosphate synthase activity; a polypeptide having ent-Kaurene synthase activity; a polypeptide having ent-Kaurene oxidase activity; and a polypeptide having kaurenoic acid 13-hydroxylase activity, whereby expression of the nucleotide sequence(s) confer(s) on the microorganism the ability to produce at least steviol, and wherein said recombinant microorganism has been modified in its genome such that it results in a deficiency in the production of one or more of: (i)
    a phosphatase capable of acting on geranylgeranylpyrophosphate (GGPP) resulting in the formation of geranylgeraniol (GOH); (ii) a phosphatase capable of acting on farnesylpyrophosphate (FPP) resulting in the formation of farnesol and nerolidol; (iii) an exo-1,3-β glucanase; (iv) a glycogen synthase (or a polypeptide that influences glycogen accumulation); (v) a transcriptional repressor of hypoxic genes (ROX1) (vi) an NADPH oxidase; or (vii) a monocarboxylate transporter (JEN1) (viii) a polypeptide having activity as encoded for by the open reading frame, YJL064w; or (ix) a polypeptide The recombinant microorganism may also be capable of expressing one or more UDP-glucosyltransferases such that the microorganism is capable of producing one or more steviol glycosides.

    TRICYCLIC CONDENSED HETEROCYCLIC COMPOUND, METHOD FOR PRODUCING SAME, AND USE THEREOF
    8.
    发明公开
    TRICYCLIC CONDENSED HETEROCYCLIC COMPOUND, METHOD FOR PRODUCING SAME, AND USE THEREOF 有权
    TRICYCLISCHE KONDENSIERTE HETEROCYCLISCHE VERBINDUNG，HERSTELLUNGSVERFAHRENDAFÜRUND VERWENDUNG DAVON

    公开(公告)号：EP2415768A1

    公开(公告)日：2012-02-08

    申请号：EP10758499.7

    申请日：2010-03-24

    申请人： Nippon Suisan Kaisha, Ltd.

    发明人： SATO, Seizo ,  IWATA, Fumie ,  YAMADA, Shoichi ,  TAKEO,Jiro ,  ABE, Akihisa ,  KAWAHARA, Hiroyuki

    IPC分类号： C07D307/77 ,  A61K31/343 ,  A61K35/74 ,  A61P35/00 ,  C12P15/00 ,  C12P17/04

    CPC分类号： C07D307/93 ,  C07D307/77 ,  C12P17/04 ,  C12R1/465

    摘要： A novel compound derived from the culture product of an actinomycete and having an antitumor activity is provided. Provided is a compound represented by any one of formulas (I), (II) and (III)



    or an optical isomer thereof or a pharmaceutically acceptable salt thereof which can be isolated from the culture fluid of an actinomycete which belongs to the genus Streptomyces,
    wherein R 1 R 2 , R 5 and R 6 each independently represent a hydrogen atom, a methyl group, a hydroxymethyl group, a hydroxyl group, or a double bond by which R 1 and R 2 or R 5 and R 6 are bonded; R 3 , R 4 , R 7 and R 8 each independently represent a methyl group or a hydroxymethyl group; and R 9 represents a hydrogen atom or a hydroxyl group.

    摘要翻译： 提供衍生自放线菌培养物并具有抗肿瘤活性的新化合物。 提供可以从属于链霉菌属的放线菌的培养液中分离的由式（I），（II）和（III）中的任何一种表示的化合物或其旋光异构体或其药学上可接受的盐， 其中R 1 R 2，R 5和R 6各自独立地表示氢原子，甲基，羟甲基，羟基或R 1和R 2或R 5和R 6键合的双键。 R 3，R 4，R 7和R 8各自独立地表示甲基或羟甲基; R 9表示氢原子或羟基。

    ENHANCED PRODUCTION OF TAXANES BY CELL CULTURES OF TAXUS SPECIES
    10.
    发明授权
    ENHANCED PRODUCTION OF TAXANES BY CELL CULTURES OF TAXUS SPECIES 失效
    提高了生产的紫杉烷红豆杉树种的细胞培养物

    公开(公告)号：EP0954596B1

    公开(公告)日：2006-01-04

    申请号：EP97926731.7

    申请日：1997-05-27

    申请人： PHYTON, INC.

    发明人： BRINGI, Venkataraman ,  KADKADE, Prakash, G. ,  PRINCE, Christopher, L. ,  ROACH, Braden, L.

    IPC分类号： C12P15/00

    CPC分类号： C12N5/0025 ,  C12P15/00 ,  C12P17/02

    摘要： This invention provides methods whereby taxol, baccatin III, and other taxol-like compounds, or taxanes, can be produced in very high yield from all known Taxus species, e.g., brevifolia, canadensis, cuspidata, baccata, globosa, floridana, wallichiana, media and chinensis. Particular modifications of culture conditions (i.e., media composition and operating modes) have been discovered to enhance the yield of various taxanes from cell culture of all species of Taxus. Particularly preferred enhancement agents include silver ion or complex, jasmonic acid (especially the methyl ester), auxin-related growth regulators, and inhibitors of the phenylpropanoid pathway, such as 3,4-methylenedioxy-6-nitrocinnamic acid. These enhancement agents may be used alone or in combination with one another or other yield-enhancing conditions. While the yield of taxanes from plant cell culture of T. chinensis is particularly enhanced by use of one or more of these conditions, yield of taxanes for all Taxus species has been found to benefit from use of these conditions.