公开(公告)号：EP0888777A3

公开(公告)日：1999-06-02

申请号：EP98108774.5

申请日：1992-12-11

申请人： UNIVERSITY OF SASKATCHEWAN

发明人： Babiuk, Lorne ,  Van den Hurk, Sylvia ,  Zamb, Tim ,  Fitzpatrick, David

IPC分类号： A61K39/265 ,  C07K14/03 ,  C12N15/38

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/53 ,  A61K2039/70 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2710/14143 ,  C12N2710/16622 ,  C12N2710/16634 ,  C12N2710/16722 ,  C12N2710/16734 ,  C12N2710/16771 ,  C12N2710/24143 ,  C12N2830/30 ,  G01N33/6854 ,  G01N2333/03

摘要： Recombinant subunit vaccines against bovine herpesvirus type 1 (BHV-1) are provided, as well as methods of vaccination and methods of recombinantly producing the subunit antigens or nucleotide sequences employed in the vaccines. Preferably, the subunit is a truncated BHV-1 gIV antigen.

公开(公告)号：EP0618814B1

公开(公告)日：1999-04-14

申请号：EP92924523.1

申请日：1992-12-11

申请人： UNIVERSITY OF SASKATCHEWAN

发明人： BABIUK, Lorne ,  VAN DEN HURK, Sylvia ,  ZAMB, Tim ,  FITZPATRICK, David

IPC分类号： A61K39/265 ,  C07K14/06 ,  C12N15/38

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/53 ,  A61K2039/70 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2710/14143 ,  C12N2710/16622 ,  C12N2710/16634 ,  C12N2710/16722 ,  C12N2710/16734 ,  C12N2710/16771 ,  C12N2710/24143 ,  C12N2830/30 ,  G01N33/6854 ,  G01N2333/03

公开(公告)号：EP0253887B1

公开(公告)日：1993-08-04

申请号：EP87902456.0

申请日：1986-12-22

申请人： THE TEXAS A&M UNIVERSITY SYSTEM

发明人： CUMMINS, Joseph, M., Jr.

IPC分类号： A61K37/66 ,  A61K39/265

CPC分类号： A61K39/39 ,  A61K2039/55522 ,  Y10S435/811

摘要： A biologically active interferon can be administered to an animal in conjunction with the administration of a vaccine to improve the vaccine efficiency and allow the use of a smaller vaccination dose. This procedure will cause a less severe vaccine infection in the animal than if no interferon was administered.

公开(公告)号：EP0316658A1

公开(公告)日：1989-05-24

申请号：EP88118266.1

申请日：1988-11-02

申请人： NOVAGENE, INC. ,  BAYLOR COLLEGE OF MEDICINE

发明人： Kit, Malon ,  Kit, Saul ,  Otsuka, Haruki

IPC分类号： C12N15/38 ,  A61K39/265

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/265 ,  A61K2039/5254 ,  A61K2039/552 ,  C12N15/00 ,  C12N2710/16722 ,  C12N2710/16734

摘要： Infectious bovine rhinotracheitis virus (bovine herpesvirus type 1) mutants containing deletion and/or insertion mutations in a major viral glycoprotein gene, such that no antigenic polypeptides encoded by the viral gene are produced, vaccines for infectious bovine rhinotracheitis containing the same, methods for the production of the same and methods for use of the same. Animals vaccinated with these mutants do not develop antibodies to the viral glycoprotein and can be distinguished serologically from animals infected with infectious bovine rhinotracheitis virus field strains.

摘要翻译： 传染性牛鼻气管炎病毒（牛疱疹病毒1型）的突变体含有缺失和/或插入突变在一个主要的病毒糖蛋白基因，谋求确实由病毒基因编码的无抗原性多肽的生产，感染性牛鼻气管炎疫苗含有相同，对于方法 生产同样的方法，并使用相同的。 与合成的突变体接种的动物不产生抗体的病毒糖蛋白，可以从感染牛传染性鼻气管炎病毒野毒株的动物血清学区分。

公开(公告)号：EP0129923B1

公开(公告)日：1988-09-07

申请号：EP84200796.5

申请日：1984-06-05

申请人： DUPHAR INTERNATIONAL RESEARCH B.V

发明人： Roerink, Jan H.G.

IPC分类号： A61K9/00 ,  A61K39/39 ,  A61K39/245 ,  A61K39/155 ,  A61K39/265 ,  A61K39/295

CPC分类号： A61K39/245 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/55566 ,  A61K2039/70 ,  C12N2710/16734 ,  C12N2760/16134 ,  C12N2760/18534 ,  Y10S424/813 ,  Y10S424/815

公开(公告)号：EP0226029A1

公开(公告)日：1987-06-24

申请号：EP86115455.7

申请日：1986-11-07

申请人： NOVAGENE, INC. ,  Baylor College of Medicine

发明人： Kit, Malon ,  Kit, Saul

IPC分类号： A61K39/265

CPC分类号： C12N15/00 ,  A61K39/12 ,  A61K39/245 ,  C12N2710/16734 ,  Y10S424/813 ,  Y10S424/822 ,  Y10S930/224

摘要： Bovine herpesvirus type 1 (infectious bovine rhinotracheitis virus) mutants which fail to produce any functional thymidine kinase as a result of a deletion in the thymidine kinase gene. The deletion in the thymidine kinase gene attenuates the viruses so that they can be used as an active agent in a modified live-virus vaccine against infectious bovine rhino­tracheitis. This invention also relates to methods for the production and use of the same.

公开(公告)号：EP3766514A1

公开(公告)日：2021-01-20

申请号：EP19743855.9

申请日：2019-01-24

申请人： National Federation of Agricultural Cooperative Associations ,  Uchida, Tetsuya

发明人： NAKANISHI, Makoto ,  SHIMA, Ryouichi ,  NAMIMATSU, Takanori ,  SUZUKI, Goro ,  UCHIDA, Tetsuya

IPC分类号： A61K39/00 ,  A61K9/127 ,  A61K39/265 ,  A61K47/69 ,  A61P31/12 ,  A61P37/04 ,  C07K14/165

摘要： Disclosed is a vaccine for non-human animals, which vaccine enables effective immune induction in non-human animals such as livestock or poultry. The vaccine for non-human animals of the present invention comprises liposomes each comprising an antigen molecule(s) bound to the surface thereof, the antigen molecule(s) being derived from a pathogen infectious to the non-human animals. The non-human animals are, for example, livestock or poultry. One most preferred example of the vaccine according to the present invention is an infectious bronchitis virus (IBV) vaccine, which is effective against various isolated IBV strains, and which is expected to be sufficiently applicable even to cases where a mutant strain appeared. Another preferred example of the vaccine according to the present invention is a PRRSV vaccine, which was confirmed to have an effect that reduces fever, lung lesion development, and the like caused by the infection. The present invention enables development of liposome vaccines effective for prevention of infections caused by various non-human animal pathogens including PRRSV as well as IBV.

公开(公告)号：EP2712624B1

公开(公告)日：2019-11-06

申请号：EP13195822.5

申请日：2006-11-15

申请人： Boehringer Ingelheim Vetmedica GmbH

发明人： Elbers, Knut ,  Knittel, Jeffrey P ,  Meyers, Gregor ,  Tremblay, Gregor ,  Jones, Craig ,  Lischewski, Axel

IPC分类号： A61K39/00 ,  C12N7/00 ,  A61K39/12 ,  A61K39/155 ,  A61K39/265 ,  A61K39/02 ,  C07K14/005

公开(公告)号：EP2968511B1

公开(公告)日：2019-02-27

申请号：EP14710257.8

申请日：2014-03-14

申请人： Intervet International B.V.

发明人： EDDY, Brad ,  QIAO, Zhisong ,  O'CONNELL, Kevin

IPC分类号： A61K39/12 ,  A61K39/155 ,  A61K39/245 ,  A61K39/295 ,  A61K39/265 ,  A61K39/00 ,  A61K35/76 ,  A61K47/18 ,  A61K47/26 ,  A61P31/12

公开(公告)号：EP3389706A1

公开(公告)日：2018-10-24

申请号：EP16822318.8

申请日：2016-12-12

申请人： Boehringer Ingelheim Vetmedica, Inc.

发明人： HESS, Jennifer Christine

IPC分类号： A61K39/125 ,  A61K39/23 ,  A61K39/265 ,  A61K39/00

CPC分类号： A61K39/265 ,  A61K39/12 ,  A61K39/23 ,  A61K2039/525 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/552 ,  A61K2039/70 ,  C12N2710/16734 ,  C12N2750/14034 ,  C12N2770/16034

摘要： The present invention relates to a hybrid vaccine for protecting a feline against diseases associated with respiratory diseases. The vaccine commonly includes a feline antigen. Methods for protecting felines against diseases associated with feline gastrointestinal and respiratory diseases, including but not limited to feline calicivirus, feline rhinotracheitis and feline panleukopenia, and methods of producing the feline vaccine are also provided.