公开(公告)号：EP2010089A2

公开(公告)日：2009-01-07

申请号：EP07755754.4

申请日：2007-04-20

申请人： The Children's Hospital of Philadelphia ,  Drexel University

发明人： LEVY, Robert, J. ,  ALFERIEV, Ivan ,  CHORNY, Michael ,  FISHBEIN, Ilia ,  FRIEDMAN, Gary ,  POLYAK, Boris ,  WILLIAMS, Darryl

IPC分类号： A61B19/00

CPC分类号： A61K9/0009 ,  A61B2017/00876 ,  A61B2017/00893 ,  A61K9/0019 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/624 ,  A61L2400/12 ,  A61N2/002 ,  A61N2/06

摘要： A therapeutic system and a method that uses stents, and/or other implantable devices (104) for local delivery of a therapeutic agent is disclosed. A therapeutic formulation (102) may include particles of a biocompatible magnetic or magnetizable material that carry the therapeutic agent, or magnetically responsive cells. The therapeutic formulation (102) is intravenously administered to a mammalian subject. A portion of the formulation (102) is delivered to the proximity of a device (104) implanted in the vascular system of the subject by externally generating a magnetic field gradient (106) on the implantable device (104). The portion of the therapeutic formulation (102) not delivered to the proximity of the implantable device (104) is removed from the vascular system. The method allows for the repeated administration of the same or different therapeutic agent, and further, has the option of locally injecting, or alternatively, peripherally administering, the therapeutic agent.

公开(公告)号：EP1977224A2

公开(公告)日：2008-10-08

申请号：EP07762595.2

申请日：2007-01-23

申请人： Drexel University

发明人： MUTHARASAN, Rajakkannu ,  MARALDO, David ,  CAMPBELL, Gossett ,  RIJAL, Kishan

IPC分类号： G01N27/00 ,  B06B1/06 ,  G01N29/02 ,  G01N29/036 ,  B81B3/00 ,  H01L41/113

CPC分类号： G01N29/022 ,  G01H11/08 ,  G01H13/00 ,  G01N29/036 ,  G01N33/54373 ,  G01N2291/0256 ,  G01N2291/0426 ,  G01N2291/0427 ,  H01L41/1132

摘要： A piezoelectric cantilever sensor includes a piezoelectric layer and a non-piezoelectric layer, a portion of which is attached to the piezoelectric layer. In one embodiment, one end of the non-piezoelectric layer extends beyond the end of piezoelectric layer to provide an overhang. The overhang piezoelectric cantilever sensor enables increased sensitivity allowing application of the device in more viscous environments, such as liquid media, as well as application in liquid media at higher flow rates than conventional piezoelectric cantilevers. In another embodiment, the sensor includes first and second bases and at least one of the piezoelectric layer and the non- piezoelectric layer is affixed to each of the first and second bases to form the piezoelectric cantilever sensor. In this embodiment, the sensor is robust and exhibits excellent sensing characteristics in both gaseous and liquid media, even when subjected to relatively high flow rates.

公开(公告)号：EP1544071B1

公开(公告)日：2008-02-13

申请号：EP04029607.1

申请日：2004-12-14

申请人： NISSAN MOTOR CO., LTD. ,  Drexel University

发明人： Kuge, Nobuyuki ,  Yamamura, Tomohiro ,  Salvucci, Dario

IPC分类号： B60T8/00

CPC分类号： B60W40/09 ,  B60T2201/08 ,  B60T2201/086 ,  B60W50/10

公开(公告)号：EP1876986A2

公开(公告)日：2008-01-16

申请号：EP06751183.2

申请日：2006-04-25

申请人： Drexel University

发明人： GUTSOL, Alexander ,  FRIDMAN, Alexander ,  FRIEDMAN, Gary ,  FRIDMAN, Gregory ,  BALASUBRAMANIAN, Manjula

IPC分类号： A61B18/18

CPC分类号： A61B18/042 ,  A61N1/40 ,  H05H1/2406 ,  H05H2001/2412 ,  H05H2240/20 ,  H05H2245/122

摘要： Method for the non-thermal treatment of human or animal tissue with high- voltage electrical discharge plasma is disclosed. The disclosed method employs current through plasma and through tissue not for the purpose of heating the tissue, but instead to maintain the plasma proximate to the tissue being treated. Also disclosed is a method of limiting the current through plasma and through tissue to minimize tissue heating by placement of an insulator or semiconductor between an electrode and tissue resulting in generation of a high- voltage discharge similar to a dielectric barrier discharge. The disclosed non-thermal plasma treatment can be employed to promote coagulation of blood, sterilization, disinfection, re- connection of tissue, and treatment of tissue disorders without causing significant thermal tissue damage.

公开(公告)号：EP1742974A2

公开(公告)日：2007-01-17

申请号：EP05804814.1

申请日：2005-05-06

申请人： Drexel University ,  THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE ARMY

发明人： PALMESE, Guiseppe, Raffaello ,  LA SCALA, John, Joseph ,  SANDS, James, Matthew

IPC分类号： C08F20/44

CPC分类号： C08F220/26 ,  C08F212/08 ,  C08F220/06 ,  C08F220/28 ,  C08F220/62 ,  C08F290/064 ,  C08G59/1466 ,  C08L63/10 ,  C08L2666/14

摘要： Multi-modal vinyl ester resins having one or more of good fracture toughness, good processing viscosity, and low volatile organic compound emissions are provided. The multi-modal vinyl ester resins are the reaction product of a liquid or crystalline epoxy and an amorphous, solid epoxy, as determined at 25°C, with a vinyl carboxylic acid. The multi-modal vinyl ester resins may contain a reactive diluent, though generally, lower reactive diluent contents are required for such resins than for similar, commercially available vinyl ester resins.

公开(公告)号：EP1229873A2

公开(公告)日：2002-08-14

申请号：EP00976709.6

申请日：2000-10-27

申请人： Drexel University

发明人： MARCOLONGO, Michele, Staud ,  LOWMAN, Anthony, Michael

IPC分类号： A61F2/44

CPC分类号： A61L27/26 ,  A61F2/441 ,  A61L2430/38 ,  A61L27/52 ,  C08L29/04 ,  C08L39/06

摘要： A prosthetic nucleus prepared from blends of polyvinylalcohol and polyvinyl pyrollidone or its copolymers for replacement of the nucleus pulposus in intervertebral discs is provided. Also provided are methods of replacing the nucleus pulposus and treating disc degeneration-associated pain in mammals using this prosthetic nucleus.

公开(公告)号：EP0868403A1

公开(公告)日：1998-10-07

申请号：EP96940401.0

申请日：1996-11-13

申请人： DREXEL UNIVERSITY

发明人： BARSOUM, Michel ,  EL-RAGHY, Tamer ,  BRODKIN, Dmitri ,  ZAVALIANGOS, Antonios ,  KALIDINDI, Surya

IPC分类号： C01B35 ,  C04B35

CPC分类号： C04B35/645 ,  C01B35/04 ,  C04B35/5611 ,  C04B35/5615 ,  C04B35/58014 ,  C04B35/58071 ,  C04B35/6455

摘要： Products having single phases or solid solutions of the formula M3X1Z2 wherein M is a transition metal, X is Si, Al or Ge and Z is B, C or N can be prepared by taking a powdered mixture containing M, X and Z to a temperature of about 1000 °C to about 1800 °C, optionally simultaneously under a pressure of about 5 MPa to about 200 MPa. The products so formed have excellent shock resistance, oxidation resistance and machinability. The products may also be present as composites, preferably composites which are in thermal equilibrium with the single phase or solid solutions of the formula M3X1Z2.

公开(公告)号：EP0809613A1

公开(公告)日：1997-12-03

申请号：EP96905481.0

申请日：1996-02-14

申请人： DREXEL UNIVERSITY ,  By-Products Development Co.

发明人： SILVERSTRIM, Thomas ,  ROSTAMI, Hossein ,  LARRALDE, Jesus ,  SAMADI, Anamolah

IPC分类号： C04B12 ,  C04B28

CPC分类号： C04B12/04 ,  C04B28/26 ,  Y02W30/92 ,  Y10S106/01 ,  C04B7/02 ,  C04B18/08 ,  C04B20/0048 ,  C04B40/0263

摘要： Rapid curing, high strength cementitious binder mixtures are provided containing fly ash and an alkali silicate binder that has a weight ratio of SiO2:M2O of about 0.20:1 to about 0.75:1 wherein M is selected from the group consisting of Li, Na, K, Ca and Mg. The cementitious binder mixtures can be mixed with aggregates to provide mortar and concrete mixtures. Any of the binder, mortar and concrete mixtures can be cured under elevated temperatures to yield high strenght products.

公开(公告)号：EP0668798A1

公开(公告)日：1995-08-30

申请号：EP94904375.0

申请日：1993-11-08

申请人： DREXEL UNIVERSITY ,  OPHTHALMIC RESEARCH CORPORATION

发明人： KAMEL, Ihab ,  SOLL, David, B.

IPC分类号： A61L27 ,  A61F2 ,  A61L33 ,  B05D3 ,  B05D7 ,  B29C59 ,  C08J7 ,  C23C8

CPC分类号： A61L27/14 ,  A61F2/16 ,  A61F2002/009 ,  A61L27/16 ,  A61L27/34 ,  A61L33/0088 ,  A61L33/08 ,  B05D1/62 ,  B05D3/144 ,  B29C59/14 ,  B29K2995/0056 ,  C08J7/18 ,  C23C8/36 ,  C08L51/00 ,  C08L5/00

摘要： The surface of a substrate material may be permanently modified so as to develop a microscopically smooth, biocompatible surface thereon. A biocompatible polymeric material may be covalently grafted to the surface of the substrate material by radio frequency plasma-induced grafting. The biocompatible polymeric material is preferably the same as the substrate material but may be different. Before grafting, a portion of the substrate surface may be first removed, as by etching, in a radio frequency plasma reactor using inert argon gas. Alternatively, the surface of the substrate material may be subjected to radio frequency plasma sufficient to raise the temperature at the substrate surface to just above the glass transition temperature (Tg) of the substrate material for a time sufficient to produce a microscopically smooth, biocompatible surface on the substrate material. The methods may be used to produce a prosthesis used in mammals, including an intraocular lens, having a polymeric material core and a biocompatible polymeric material covalently grafted to the polymer core by radio frequency plasma treatment.

公开(公告)号：EP0543896A1

公开(公告)日：1993-06-02

申请号：EP91915007.0

申请日：1991-07-16

申请人： DREXEL UNIVERSITY

发明人： ZUCKERMAN, Ralph

IPC分类号： A61B5 ,  A61B3 ,  G01N21

CPC分类号： A61B5/14555 ,  A61B3/1241

摘要： Méthode de mesure in vivo de niveaux de concentration d'oxygène dans des fluides ou des tissus d'animaux, consistant notamment: à administrer à l'animal une substance sonde fluorescente, biocompatible, sensible à la réduction d'oxygène et possédant une intensité de fluorescence non réduite connue, en une quantité suffisante pour permettre à la sonde de s'accumuler dans le fluide ou dans les tissus; à exposer le fluide ou les tissus à la lumière d'excitation; à mesurer l'intensité de l'émission de lumière fluorescente de la sonde dans le fluide ou dans les tissus et à déterminer le niveau de concentration d'oxygène du fluide ou des tissus en comparant l'intensité de fluorescence non réduite connue avec l'intensité de fluorescence mesurée. Ladite méthode utilise de préférence une sonde fluorescente biocompatible comprenant de l'acide pyrènebutyrique ou sa forme de sel biocompatible.