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21.发明公开SUSTAINED RELEASE COMPOSITION CONTAINING TETRAHYDROPYRIDO Ý4, 3-b¨INDOLE DERIVATIVE AND PREPARATION METHOD OF DERIVATIVE 有权WITH四氢吡啶并[4,3-b]吲哚衍生物及其制备方法，在Derivative RETARDZUSAMMENSETZUNG
公开(公告)号：EP2417973A4
公开(公告)日：2012-04-25
申请号：EP10761171
申请日：2010-03-29
发明人： LI SONG , ZHONG WU , ZHENG ZHIBING , XIAO JUNHAI , LI BING , XIE YUNDE , ZHOU XINBO
CPC分类号： A61K31/44 , A61K9/1641 , A61K9/2031 , A61K9/2077 , C07D471/04
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公开(公告)号：EP2354136A4
公开(公告)日：2012-04-18
申请号：EP09818738
申请日：2009-09-28
发明人： LI JIN , YANG RIFANG , SONG RUI , ZHU HUI , WU NING , YUN LIUHONG , SU RUIBIN , ZHAO RUSHENG
IPC分类号： C07D413/12 , A61K31/496 , A61P25/00 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号： A61K31/496 , C07D263/58 , C07D277/68 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
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23.发明公开DERIVATES OF SUBSTITUTED TARTARIC AICD AND USAGE FOR PREPARATING BETA SECRETASE INHIBITORS 有权衍生物取代中的葡萄酒酸和使用制备βSEKRETASEHEMMERN
公开(公告)号：EP2116526A4
公开(公告)日：2012-02-29
申请号：EP07702276
申请日：2007-02-05
发明人： LI SONG , LIAO GUOCHAO , XIAO JUNHAI , NIE AIHUA , WANG LILI , ZHONG WU , ZHENG ZHIBING
IPC分类号： C07C235/12 , A61K31/16 , A61K31/4965 , A61P25/00 , A61P25/28 , A61P43/00 , C07D235/06 , C07D241/04
CPC分类号： C07C235/16 , C07C235/12 , C07C237/42 , C07C2601/14 , C07D235/06 , C07D295/185
摘要： The present invention relates to compounds represented by formula (I), or isomers, prodrugs, pharmaceutically acceptable salts, solvates or hydrates thereof: in which each substituent of formula (I) is as defined in the specification. The present invention also relates to preparation methods of compounds represented by formula (I), a pharmaceutical composition comprising compounds represented by formula (I) and usage of compounds represented by formula (I) for treating chronic neurodegenerative diseases such as Alzheimer's disease and other diseases induced by aggregation or deposition of ²-amyloid peptide.
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24.发明公开AMINE DERIVATIVE WITH POTASSIUM CHANNEL REGULATORY FUNCTION, ITS PREPARATION AND USE 有权钾通道功能的调节谁的HERSTELUNG和使用AMIN衍生物
公开(公告)号：EP1386908A4
公开(公告)日：2006-07-12
申请号：EP02716048
申请日：2002-01-21
发明人： WANG HAI , YANG RIFANG , LONG CHAOLIANG , YUN LIUHONG , CUI WENYU , WANG LIN , FENG HUASONG , GAO QIXIU , LU XINQIANG , LI FULIN , HU GANG , LIU LIJUN , TANG XINGCHUN , ZHAO RUSHENG , YAN YUAN , HE HUAMEI , LIU WEI
IPC分类号： A61K31/13 , A61K31/131 , A61K31/132 , A61K31/136 , A61K31/137 , A61K31/16 , A61K31/165 , A61K31/18 , A61K31/405 , A61K31/455 , A61P1/06 , A61P3/10 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/06 , A61P17/12 , A61P25/00 , A61P25/08 , A61P25/24 , A61P25/28 , A61P43/00 , C07B61/00 , C07C209/04 , C07C209/28 , C07C211/08 , C07C211/09 , C07C211/17 , C07C211/21 , C07C211/27 , C07C213/04 , C07C215/08 , C07C231/02 , C07C233/11 , C07C235/34 , C07C237/06 , C07C237/20 , C07C243/02 , C07C303/38 , C07C311/16 , C07D209/20 , C07D213/82 , C07C209/18 , C07C211/18 , C07C215/00 , C07C229/06 , C07C233/64 , C07C311/17 , C07D233/44 , C07D263/28 , C07D295/15
CPC分类号： C07D213/82 , A61K31/13 , C07C211/08
摘要： The present invention relates to an amine derivative of formula I, its isomer, racemate or optical isomer, pharmaceutical salt, its amide or ester, a medicinal composition containing these, and the preparation of the same. The invention also relates to the use of these compounds in preparing medicines for preventing or treating cardiovascular diseases, diabetes, bronchus and urinary system smooth muscle convulsion, and nerve damage due to ischemia and anoxia. These compounds can be used to treat hypertension, angina, cardiac infraction, congestive heart-failure, arrhythmia, diabetes, bronchial spasm diseases, bladder or ureter spasm diseases, and depression.
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公开(公告)号：EP0734724A4
公开(公告)日：1998-02-04
申请号：EP94930141
申请日：1994-10-22
发明人： LIU CHUANHUI , YUN LIUHONG , WEN GUANGLING , ZENG FANZHONG , YU RUIQI , YU GUIHUA , WANG XIAOMING , WANG WEIXIAN , WANG AIPING
IPC分类号： C07D471/08 , A61K9/20 , A61K9/70 , A61K31/435 , B01J23/04 , C07B61/00 , C07D221/22 , A61K31/445 , C07D487/02
CPC分类号： C07D221/22 , A61K31/435 , A61K31/439
摘要： The invention relates to a pharmaceutical composition for preventing and/or treating kinetotia syndrome, method for treatment of knetotia syndrome thereof, and method of preparing α-configuration benzene ring ester hydrochloride as active component of the pharmaceutical composition. The pharmaceutical composition according to the invention shows more effective with lower side-effect, compared with known medicines used to treat kinetotia syndrome. Furthermore, the pharmaceutical composition according to the invention is useful for preventing and/or treating various conditions, such as, centric and peripheral choline dysfunction caused by centric and peripheral hyperacetylcholine.
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26.发明公开JOINT PRODUCT CONTAINING PHENTERMINE AND TOPIRAMATE AND PREPARATION METHOD THEREFOR 有权随着产品芬特明和托吡酯及其制造方法CONNECTION
公开(公告)号：EP2829266A4
公开(公告)日：2015-11-11
申请号：EP13763543
申请日：2013-03-20
发明人： LI SONG , GAO CHUNSHENG , ZHONG WU , WANG YULI , YANG MEIYAN , SHAN LI , ZHOU XINBO , ZHENG ZHIBING , WANG XIAOKUI
CPC分类号： A61K31/357 , A61K9/4808 , A61K9/5047 , A61K9/5078 , A61K9/5084 , A61K9/5089 , A61K31/137 , A61K2300/00
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27.发明公开TOPIRAMATE SUSTAINED-RELEASE PHARMACEUTICAL COMPOSITION, METHOD FOR PREPARING SAME, AND USE THEREOF 审中-公开具有延迟释放的药物头痛眼组合物，其制备方法及其用途
公开(公告)号：EP2829267A4
公开(公告)日：2015-09-30
申请号：EP13763714
申请日：2013-03-07
发明人： LI SONG , GAO CHUNSHENG , ZHONG WU , WANG YULI , YANG MEIYAN , SHAN LI , ZHOU XINBO , ZHENG ZHIBING , WANG XIAOKUI
IPC分类号： A61K9/22 , A61K31/7048 , A61K47/32 , A61K47/38 , A61P3/10 , A61P9/12 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/24
CPC分类号： A61K31/357 , A61K9/1676 , A61K9/5026 , A61K9/5042 , A61K9/5078 , A61K9/5089 , A61K31/7048
摘要： A sustained-release pharmaceutical composition of topiramate, which is free of binding agent. The sustained-release pharmaceutical composition of topiramate is a sustained-release pellet, comprising a blank pellet core, a drug layer, and a sustained-release coating layer.
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28.发明公开JOINT PRODUCT CONTAINING SYNEPHRINE AND TOPIRAMATE 审中-公开VERBINDUNGSPRODUKT MIT SYNEPHRIN UND TOPIRAMAT
公开(公告)号：EP2829270A4
公开(公告)日：2015-09-23
申请号：EP13764754
申请日：2013-03-22
发明人： LI SONG , GAO CHUNSHENG , ZHONG WU , WANG YULI , YANG MEIYAN , SHAN LI , ZHOU XINBO , ZHENG ZHIBING , WANG XIAOKUI
IPC分类号： A61K31/357 , A61K9/16 , A61K9/30 , A61K9/50 , A61K31/137 , A61P3/04
CPC分类号： A61K31/357 , A61K9/1635 , A61K9/1652 , A61K9/1676 , A61K9/5026 , A61K9/5047 , A61K9/5078 , A61K9/5084 , A61K9/5089 , A61K31/137 , A61K31/7048 , A61K45/06 , A61K2300/00
摘要： The present invention provides a joint product comprising synephrine and topiramate, in which the synephrine or salt thereof is administered in form of rapid-release preparation, preferably rapid-release pellet, having daily dose of 2mg to 25mg, preferably 5mg to 20mg; the topiramate is administered in form of sustained-release or controlled-release preparation, preferably sustained-release pellet, having daily dose of 20mg to 100mg, preferably 23mg to 92mg. The composition is used for treatment of obesity or other diseases associated with obesity.
摘要翻译： 本发明提供了包含昔萘福芬和托吡酯的联合产品，其中以每日剂量为2mg至25mg，优选5mg至20mg的快速释放制剂，优选快速释放丸剂的形式施用昔萘福林或其盐; 托吡酯以持续释放或控释制剂的形式施用，优选缓释丸剂，其日剂量为20mg至100mg，优选为23mg至92mg。 该组合物用于治疗与肥胖相关的肥胖或其它疾病。
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29.发明公开
公开(公告)号：EP2792372A4
公开(公告)日：2015-07-01
申请号：EP12846724
申请日：2012-10-31
发明人： LIU KELIANG , XU LIANG , ZHANG QINGSONG , CAI DAZHEN , MENG QINGBIN
IPC分类号： A61L24/06 , A61L24/00 , C08F222/32 , C08L35/04 , C09J4/04 , C09J135/04
CPC分类号： A61L24/06 , A61L24/0015 , A61L24/0042 , A61L24/043 , C08F222/32 , C08F283/02 , C08F2222/324 , C08F2222/326 , C08L2312/00 , C09J4/00 , C09J133/14 , C09J133/20 , C08L35/04 , C08F2222/322 , C08F2220/286 , C08F2222/328
摘要： Provided is a medical adhesive with good biodegradable performance capable of undergoing crosslinking copolymerization, comprising a mono-alpha-cyanoacrylate and a bis-alpha-cyanoacrylic acid diol ester monomer molecule. The olefinic bonds in the mono-alpha-cyanoacrylate structure are polymerized in the presence of infinitesimal anions to form a solid 3D high polymer; the 3D high polymer is provided with degradation sites on the web-like backbone chain, with clear degradation path and absorbable degradation products. The medical adhesive can be used for wound adhesive, large area wound hemostasia, and visceral and soft tissue wound closure. Furthermore, the medical adhesive also has the potential to be used as a tissue engineered material.
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30.发明公开
公开(公告)号：EP2573067A4
公开(公告)日：2014-10-29
申请号：EP11782849
申请日：2011-05-16
发明人： LI SONG , ZHONG WU , LIU PING , XIAO JUNHAI , ZHENG ZHIBING , XIE YUNDE , ZHAO GUOMING , WANG XIAOKUI , WANG LILI , LI XINGZHOU , ZHOU XINBO
IPC分类号： C07C215/62 , A61K31/137 , A61P31/06 , C07C217/72
CPC分类号： C07C217/72 , A61K31/137 , C07C213/00 , C07C215/62
摘要： The present invention relates to aromatic butan-2-ol compounds and preparation methods and uses thereof. Specifically, the present invention relates to the compound of Formula I, or an optical isomer, racemate, diastereomer, pharmaceutically acceptable salt or solvate thereof: wherein each of the substituents have the definitions as given in the specification. The present invention further relates to a pharmaceutical composition containing the compound, and the use of the compound in manufacture of a medicament for the treatment and/or prophylaxis of a disease or disorder caused by tubercle bacillus infection. The compound of Formula I of the present invention has advantages in treatment and/or prophylaxis of a disease or disorder caused by tubercle bacillus infection.
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