3-HYDROXYANTHRANILIC ACID (3-HAA) THERAPY FOR PREVENTION AND TREATMENT OF HYPERLIPIDEMIA AND ITS CARDIOVASCULAR COMPLICATIONS
    26.
    发明公开
    3-HYDROXYANTHRANILIC ACID (3-HAA) THERAPY FOR PREVENTION AND TREATMENT OF HYPERLIPIDEMIA AND ITS CARDIOVASCULAR COMPLICATIONS 有权
    疗法-3-羟基-2-氨基(3- HAA)心血管并发症及其高脂血症的预防和治疗

    公开(公告)号:EP2736505A1

    公开(公告)日:2014-06-04

    申请号:EP12820828.7

    申请日:2012-07-13

    发明人: KETELHUTH, Daniel

    IPC分类号: A61K31/196 A61P3/06

    CPC分类号: A61K31/196

    摘要: The present invention relates to the use of a tryptophan metabolite, 3- hydroxyanthranilic acid (3-HAA)or a functional analogue thereof, for prophylactic and/or therapeutic treatment of mammals, in special humans, against hyperlipidemia and its cardiovascular complications, i.e atheroma formation, myocardial infarction and heart failure, ischemic stroke and transient ischemic attacks, renal impairment, aortic aneurysms and critical limb ischemia caused by atherosclerosis.

    摘要翻译: 本发明涉及使用色氨酸代谢物,3-羟基邻氨基苯甲酸(3-HAA)或其功能类似物的,其用于哺乳动物的预防和/或治疗性治疗,在特殊人类,对高脂血症和其心血管并发症,即 动脉粥样硬化形成,心肌梗死和心脏衰竭,缺血性卒中和短暂性脑缺血发作,肾功能不全,主动脉瘤和动脉粥样硬化引起的严重肢体缺血。

    AVIAN-BASED TREATMENT FOR MICROBIAL INFECTIONS
    28.
    发明公开
    AVIAN-BASED TREATMENT FOR MICROBIAL INFECTIONS 审中-公开
    微生物感染禽流提取物治疗

    公开(公告)号:EP2704730A1

    公开(公告)日:2014-03-12

    申请号:EP12779872.6

    申请日:2012-05-02

    发明人: CHAMBERLAIN, John

    IPC分类号: A61K35/12 A61P17/00

    摘要: A method for treating or preventing microbial skin infections comprising the step of: administering to a subject in need thereof a composition comprising avian extract EP-2 in a therapeutically effective concentration together with a pharmaceutically acceptable carrier and/or diluent.

    PROCESS FOR CONTINUOUS FLOW SYNTHESIS OF BETA-AMINO CROTONATE
    29.
    发明公开
    PROCESS FOR CONTINUOUS FLOW SYNTHESIS OF BETA-AMINO CROTONATE 有权
    VERFAHRENFÜRKONTINUIERLICHE合成VON BETA-AMINO-CROTONAT

    公开(公告)号:EP2702035A2

    公开(公告)日:2014-03-05

    申请号:EP12729240.7

    申请日:2012-04-25

    IPC分类号: C07C227/06 C07C229/30

    CPC分类号: C07C227/06 C07C229/30

    摘要: Beta aminocrotonates are important intermediates for the synthesis of Ca channel blockers. The processes available in the art are batch processes with yields about 85%. There are no continuous processes available for the synthesis of such compounds. This gap in the art is addressed by the invention by disclosing a continuous process resulting in high yields of beta amino crotonates.

    摘要翻译: β-氨基巴豆酸钠是合成Ca通道阻滞剂的重要中间体。 本领域可获得的方法是分批方法,产率约85%。 没有可用于合成这种化合物的连续方法。 本发明通过公开连续的方法解决了本领域的这种差距,导致β-氨基巴豆酸酯的高产率。

    A METHOD OF SCREENING ANTI-TUBERCULAR COMPOUNDS
    30.
    发明公开
    A METHOD OF SCREENING ANTI-TUBERCULAR COMPOUNDS 审中-公开
    筛选 - VERFAHRENFÜRVERBINDUNGEN GEGEN TUBERKULOSE

    公开(公告)号:EP2686687A2

    公开(公告)日:2014-01-22

    申请号:EP12716669.2

    申请日:2012-03-16

    IPC分类号: G01N33/68

    摘要: Novel targets for screening anti tubercular targets and methods to use those targets to screen potential drugs for anti tubercular therapy are addressed through this invention. A method of screening anti-tubercular compounds that affect the binding between GroEL2 protein or a fragment thereof and a kit for screening of antitubercular drug candidates having an isolated gro EL 2 protein; Mts- Atf-Biotin Label Transfer Reagents and a culture medium comprising M. bovis BCG (ATCC 35745), M. smegmatis (ATCC 607) are disclosed.

    摘要翻译: 用于筛选抗结核靶标的新目标和使用这些靶标筛选潜在药物用于抗结核治疗的方法通过本发明来解决。 筛选影响GroEL2蛋白或其片段之间的结合的抗结核化合物和用于筛选具有分离的gro EL2蛋白的抗结核药物候选物的试剂盒的方法; Mts-Atf-生物素标记转移试剂和包含牛分枝杆菌BCG(ATCC 35745),耻垢分枝杆菌(ATCC 607)的培养基。