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21.发明公开
公开(公告)号：EP0615444A1
公开(公告)日：1994-09-21
申请号：EP92924546.0
申请日：1992-12-04
申请人： ALFATEC-PHARMA GmbH
CPC分类号： A61K9/5169 , A61K9/1658 , A61K9/2063 , A61K9/209 , A61K9/2846 , A61K9/4891 , A61K9/5026 , A61K9/5084 , A61K38/28 , G03C2001/0471
摘要： Une forme d'administration perorale de médicaments peptidiques contient un médicament peptidique, notamment l'insuline, répartie dans une matrice en gélatine ou en un dérivé de gélatine, en plus des excipients et des additifs pharmaceutiques usuels. La sélection d'une gélatine appropriée permet de libérer le médicament dans l'intestin grêle ou dans le gros intestin, de sorte qu'il ne soit plus enzymatiquement décomposé par les peptidases.
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22.发明授权PEPTIDARZNEISTOFFE ENTHALTENDE PELLETS UND IHRE HERSTELLUNG SOWIE DEREN VERWENDUNG 失效多肽药物材中含有颗粒和生产及其用途
公开(公告)号：EP0621775B1
公开(公告)日：1997-08-06
申请号：EP93902032.7
申请日：1993-01-18
申请人： ALFATEC-PHARMA GmbH
CPC分类号： A61K9/1694 , A61K9/1617 , A61K9/1623 , A61K9/1658
摘要： Described are pellets containing peptide drugs incorporated in a matrix consisting of gelatin or fractionated gelatin and plasticizers, the pellets having a semi-solid to gel-like consistency. Such drug forms exhibit, after application, bioadhesive properties and, by virtue of the matrix materials specified, allow or enhance the resorption of the peptide drug by the body.
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23.发明授权WIRKSTOFF-ENTHALTENDE FESTKÖRPER MIT EINEM GERÜST AUS HYDROPHILEN MAKROMOLEKÜLEN UND VERFAHREN ZU IHRER HERSTELLUNG 失效ACTIVE-含有固体带支架关闭生产亲水性大分子和过程
公开(公告)号：EP0621777B1
公开(公告)日：1996-09-11
申请号：EP93902034.3
申请日：1993-01-18
申请人： ALFATEC-PHARMA GmbH
CPC分类号： A61K8/64 , A61K8/0225 , A61K8/65 , A61K8/97 , A61K9/1617 , A61K9/1623 , A61K9/1658 , A61K9/1694 , A61Q19/00
摘要： The invention concerns precisely meterable moulded bodies, for instance granules or pellets, containing hydrophilic macromolecules, active substances and, optionally, other pharmaceutically acceptable structure-forming agents and auxiliaries, the active substance being dissolved in, suspended in or emulsified with a matrix. The invention also concerns a method for producing such moulded bodies, the method being particularly cost-effective and environmentally acceptable, and the use of the moulded bodies as drugs in which bio-availability, storability and compatability are increased. In addition, the moulded bodies described, or mixtures of them, are also useful in preparing intermediates or end-products for use in pharmaceutics, cosmetics, diagnosis, analysis or dietary health care.
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公开(公告)号：EP0615443B1
公开(公告)日：1996-08-14
申请号：EP92923694.1
申请日：1992-12-04
申请人： ALFATEC-PHARMA GmbH
CPC分类号： A61K9/5169 , A61K9/0056 , A61K9/0095 , A61K9/1658 , A61K9/2063 , A61K9/2095 , A61K9/5138 , A61K31/19
摘要： A medicament for immediately treating painful, inflammatory and/or febrile acute diseases contains flurbiprofen as a racemate, a mixture of a racemate with its enantiomers, a pseudoracemate (mixtures of equal parts of S- and R-flurbiprofen) or as a mixture of different parts of S- and R-flurbiprofen in the range extending between pure S- and pure R-flurbiprofen as active substance in the form of a pharmaceutically applicable nanosol. This medicament satisfies all requirements of an immediate-effect pharmaceutic form.
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25.发明授权
公开(公告)号：EP0615444B1
公开(公告)日：1996-03-06
申请号：EP92924546.2
申请日：1992-12-04
申请人： ALFATEC-PHARMA GmbH
CPC分类号： A61K9/5169 , A61K9/1658 , A61K9/2063 , A61K9/209 , A61K9/2846 , A61K9/4891 , A61K9/5026 , A61K9/5084 , A61K38/28 , G03C2001/0471
摘要： A peroral administration form for peptidic medicaments contains the peptidic medicament, in particular insulin, distributed in a gelatine or gelatine derivate matrix, besides usual pharmaceutical excipients and additives. By selecting an appropriate gelatine, the medicament is released in the small or large intestine, so that it is no longer enzymatically decomposed by peptidases.
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公开(公告)号：EP0623018B1
公开(公告)日：1995-12-27
申请号：EP93901686.1
申请日：1993-01-18
申请人： ALFATEC-PHARMA GmbH
CPC分类号： A61K9/4833 , A61J3/07
摘要： The invention concerns a drip-feed method for the manufacture of soft gelatin capsules, the preferably soft or liquid contents being enclosed in soft gelatin which is then solidified in a low-temperature cooling bath containing a chemically inert liquified gas which leaves no biologically undesirable or toxic residues on the capsules. Liquid nitrogen is preferably used as the cooling-bath liquid.
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27.发明授权EIN DIHYDROPYRIDINDERIVAT IN NANOSOLFORM ENTHALTENDES RETARD-ARZNEIMITTEL UND SEINE HERSTELLUNG 失效在纳米溶胶含药物和延迟-生产二氢吡啶衍生物。
公开(公告)号：EP0615446B1
公开(公告)日：1995-11-15
申请号：EP92924551.2
申请日：1992-12-04
申请人： ALFATEC-PHARMA GmbH
CPC分类号： A61K9/5169 , A61K9/2063 , A61K9/2095 , A61K31/44 , G03C2001/0471
摘要： Slow-release medicaments containing a pharmacologically active dihydropyridine derivate as a pharmaceutically applicable nanosol have considerably improved bioavailabilities and resorption rates, with an increased tolerability of the active substances.
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公开(公告)号：EP0615439B1
公开(公告)日：1995-11-08
申请号：EP92924545.4
申请日：1992-12-04
申请人： ALFATEC-PHARMA GmbH
CPC分类号： A61K9/5169 , A61K9/2063 , A61K9/2095 , A61K31/19
摘要： A medicament contains a slow-release composition of ibuprofen as a racemate, a mixture of racemate with its enantiomers, a pseudoracemate (mixtures of equal parts of S- and R-ibuprofen) or a mixture of different parts of S- and R-ibuprofen in the range between pure S- and ibuprofene as active substance. The slow-release ibuprofen composition constitutes a gelatine-based pharmaceutically applicable nanosol and satisfies the requirements of an efficient thereapy for rheumatism.
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公开(公告)号：EP0650354A1
公开(公告)日：1995-05-03
申请号：EP93914598.0
申请日：1993-07-05
申请人： ALFATEC-PHARMA GmbH
CPC分类号： A61K9/146 , A61K9/1658 , A61K47/42
摘要： Active substances, such as drugs, which are not readily soluble in water, are converted to the dissolved (molecular-dispersed) state by dissolving them in a hydrophilic peptide with a molecular weight of more than 100 Daltons, such as a gelatin. This ensures the solubility of the drugs both during storage and when the preparation is used by the end-user or patient, without the need for organic solvents or for solubilizers with undesirable side-effects.
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30.发明公开
公开(公告)号：EP0623018A1
公开(公告)日：1994-11-09
申请号：EP93901686.0
申请日：1993-01-18
申请人： ALFATEC-PHARMA GmbH
CPC分类号： A61K9/4833 , A61J3/07
摘要： Procédé en goutte pour la fabrication de capsules de gélatine molle, dans lequel on enrobe d'une masse de gélatine molle la matière de remplissage, de préférence pâteuse ou liquide, on solidifie la masse de gélatine dans un bain réfrigérant formé par un gaz chimiquement inerte, liquéfié à basse température, ne laissant sur la capsule aucun résidu nocif ou biologiquement nuisible. Comme bain réfrigérant, ou utilise de préférence de l'azote liquide.
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