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公开(公告)号：EP3504234A1
公开(公告)日：2019-07-03
申请号：EP17854952.3
申请日：2017-09-28
发明人： LIU, Jiawang , SONG, Nanmeng , YANG, Dongge , YANG, Yaping , KIM, Maengsup
IPC分类号： C07K16/00 , A61K39/395 , C12N15/13 , A61P37/02 , A61P35/00
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公开(公告)号：EP3336091A1
公开(公告)日：2018-06-20
申请号：EP15900787.1
申请日：2015-08-13
发明人： XUE, Baoyu , ZHENG, Runa , CHA, Mi Young , KIM, Maengsup
IPC分类号： C07D495/04 , A61K31/519 , A61K31/5377 , A61P7/02 , A61P1/04 , A61P19/02 , A61P35/00 , A61P37/00
CPC分类号： A61K31/519 , A61K31/5377 , C07D495/04
摘要： The present invention relates to a compound inhibiting the activity of an IRAK4 kinase, a pharmaceutical composition thereof, a use thereof in preparing drugs, a method in which same is used for inhibiting the activity of the IRAK4 kinase and a method in which same is used for treating and/or preventing IRAK4 kinase mediated diseases or conditions in mammals (particularly humans). The compound has a structural formula I .
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23.发明公开BIFUNCTIONAL FUSION PROTEIN, PREPARATION METHOD THEREFOR, AND USE THEREOF 审中-公开BIFUNKTIONELLES FUSIONSPROTEIN，HERSTELLUNGSVERFAHRENDAFÜRUND VERWENDUNG DAVON
公开(公告)号：EP3101035A1
公开(公告)日：2016-12-07
申请号：EP15742538.0
申请日：2015-01-28
发明人： CHEN, Guoqiang , LIU, Jiawang , SONG, Nanmeng , YANG, Yaping , CHA, Mi Young
IPC分类号： C07K19/00 , C07K16/24 , C07K14/705 , C12N15/62 , C12N15/63 , C12N5/10 , A61K38/17 , A61K39/395 , A61P37/02
CPC分类号： C07K16/244 , A61K38/00 , A61K39/00 , C07K14/7051 , C07K14/70521 , C07K16/24 , C07K2317/24 , C07K2317/92 , C07K2319/00
摘要： The present invention provides a bifunctional fusion protein comprising the extracellular region of CTLA4 and an anti-IL-17 antibody, a gene encoding the protein, a vector comprising the gene, a host cell comprising the vector, and a pharmaceutical composition containing the protein.
摘要翻译： 本发明提供了包含CTLA4的细胞外区域和抗IL-17抗体的双功能融合蛋白，编码该蛋白质的基因，包含该基因的载体，包含载体的宿主细胞和含有该蛋白质的药物组合物。
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公开(公告)号：EP3336091B1
公开(公告)日：2020-12-02
申请号：EP15900787.1
申请日：2015-08-13
发明人： XUE, Baoyu , ZHENG, Runa , CHA, Mi Young , KIM, Maengsup
IPC分类号： C07D495/04 , A61K31/519 , A61K31/5377 , A61P7/02 , A61P1/04 , A61P19/02 , A61P35/00 , A61P37/00
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公开(公告)号：EP3336090B1
公开(公告)日：2020-07-22
申请号：EP16834688.0
申请日：2016-08-12
发明人： XU, Jiangcheng , CAI, Qingyuan , CHA, Mi Young , KIM, Maengsup
IPC分类号： C07D487/04 , A61K31/4162 , A61P29/00
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公开(公告)号：EP3252038B1
公开(公告)日：2020-04-08
申请号：EP16742703.8
申请日：2016-01-22
发明人： XUE, Hai , ZHAO, Tao , CHA, Mi Young , KIM, Maengsup
IPC分类号： C07D209/08 , C07D209/10 , A61K31/404 , A61P29/00
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公开(公告)号：EP2753348B1
公开(公告)日：2019-12-11
申请号：EP12830783.2
申请日：2012-09-05
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公开(公告)号：EP3514176A1
公开(公告)日：2019-07-24
申请号：EP17850230.8
申请日：2017-09-08
发明人： SONG, Nanmeng , LIU, Jiawang , YANG, Yaping , YANG, Yang , YANG, Dongge , ZHANG, Hongjuan , JIN, Mengxie
IPC分类号： C07K16/24 , A61K47/68 , A61K39/395 , A61P37/02 , A61P19/02
摘要： An antibody specifically binding to IIL-17A or a functional fragment thereof. The antibody or functional fragment thereof includes an IL-17A chimeric antibody and a functional fragment thereof, and an IIL-17A humanized antibody and a functional fragment thereof.
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29.发明授权
公开(公告)号：EP2718317B1
公开(公告)日：2018-11-14
申请号：EP12797613.2
申请日：2012-06-08
发明人： MA, Tao , XU, Shusen , LIU, Zhijun , ZHANG, Bo , SHEN, Ning , YANG, Hai , ZHANG, Wei , LI, Yuhua , MOON, Sunghwan , KIM, Maengsup
IPC分类号： C07K14/575 , A61K38/22 , A61P3/00 , A61P3/04
CPC分类号： C07K14/575 , A61K38/00 , A61K38/16 , A61K38/22 , C07K14/00 , C07K14/605
摘要： The present invention provides a GIP analog, which is derived from GIP (1-29, SEQ ID NO: 1), has both GLP-1 agonist activity and GIPR stimulation activity, and comprises an amino acid sequence represented by the following formula I: Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp-Leu- A27-A28-A29-Y. The present invention also provides a pharmaceutical composition comprising the GIP analog and use thereof.
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30.发明公开GLUCOSE DEPENDENT INSULINOTROPIC POLYPEPTIDE ANALOGS, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF 审中-公开葡萄糖依赖性促胰岛素多肽类似物，其药物组合物及其用途
公开(公告)号：EP2718317A1
公开(公告)日：2014-04-16
申请号：EP12797613.2
申请日：2012-06-08
发明人： MA, Tao , XU, Shusen , LIU, Zhijun , ZHANG, Bo , SHEN, Ning , YANG, Hai , ZHANG, Wei , LI, Yuhua , MOON, Sunghwan , KIM, Maengsup
IPC分类号： C07K14/575 , A61K38/22 , A61P3/00 , A61P3/04
CPC分类号： C07K14/575 , A61K38/00 , A61K38/16 , A61K38/22 , C07K14/00 , C07K14/605
摘要： The present invention provides a GIP analog, which is derived from GIP (1-29, SEQ ID NO: 1), has both GLP-1 agonist activity and GIPR stimulation activity, and comprises an amino acid sequence represented by the following formula I: Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13- A14-A15-Lys-A17-A18-A19-A20-A21 -A22-A23-A24-Trp-Leu-A27-A28-A29-Y. The present invention also provides a pharmaceutical composition comprising the GIP analog and use thereof.
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