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1.发明授权
公开(公告)号：EP2718317B1
公开(公告)日：2018-11-14
申请号：EP12797613.2
申请日：2012-06-08
发明人： MA, Tao , XU, Shusen , LIU, Zhijun , ZHANG, Bo , SHEN, Ning , YANG, Hai , ZHANG, Wei , LI, Yuhua , MOON, Sunghwan , KIM, Maengsup
IPC分类号： C07K14/575 , A61K38/22 , A61P3/00 , A61P3/04
CPC分类号： C07K14/575 , A61K38/00 , A61K38/16 , A61K38/22 , C07K14/00 , C07K14/605
摘要： The present invention provides a GIP analog, which is derived from GIP (1-29, SEQ ID NO: 1), has both GLP-1 agonist activity and GIPR stimulation activity, and comprises an amino acid sequence represented by the following formula I: Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp-Leu- A27-A28-A29-Y. The present invention also provides a pharmaceutical composition comprising the GIP analog and use thereof.
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2.发明公开GLUCOSE DEPENDENT INSULINOTROPIC POLYPEPTIDE ANALOGS, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF 审中-公开葡萄糖依赖性促胰岛素多肽类似物，其药物组合物及其用途
公开(公告)号：EP2718317A1
公开(公告)日：2014-04-16
申请号：EP12797613.2
申请日：2012-06-08
发明人： MA, Tao , XU, Shusen , LIU, Zhijun , ZHANG, Bo , SHEN, Ning , YANG, Hai , ZHANG, Wei , LI, Yuhua , MOON, Sunghwan , KIM, Maengsup
IPC分类号： C07K14/575 , A61K38/22 , A61P3/00 , A61P3/04
CPC分类号： C07K14/575 , A61K38/00 , A61K38/16 , A61K38/22 , C07K14/00 , C07K14/605
摘要： The present invention provides a GIP analog, which is derived from GIP (1-29, SEQ ID NO: 1), has both GLP-1 agonist activity and GIPR stimulation activity, and comprises an amino acid sequence represented by the following formula I: Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13- A14-A15-Lys-A17-A18-A19-A20-A21 -A22-A23-A24-Trp-Leu-A27-A28-A29-Y. The present invention also provides a pharmaceutical composition comprising the GIP analog and use thereof.
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