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2961 条记录 (耗时 0.029 秒)

    TUBE-SHAPED ROBOTIC DEVICE WITH ANISOTROPIC SURFACE STRUCTURE
    23.
    发明公开
    TUBE-SHAPED ROBOTIC DEVICE WITH ANISOTROPIC SURFACE STRUCTURE 审中-公开

    公开(公告)号：EP4260830A1

    公开(公告)日：2023-10-18

    申请号：EP22167673.7

    申请日：2022-04-11

    申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

    发明人： WANG, Tianlu ,  SITTI, Metin ,  HU, Wenqi

    IPC分类号： A61B34/00 ,  A61B34/30 ,  A61F2/915

    摘要： The invention relates to a tube (100) with a hollow cylindrical elastic base structure (102) for insertion into a blood vessel (200) of a vascular system (202). The tube (100) comprises an outer anisotropic surface structure (104) comprising a geometrical anisotropy between a direction circumferential to the tube and a direction longitudinal to the tube (100). The anisotropic surface structure (104) is configured for establishing an anisotropic friction between the anisotropic surface structure (104) and an inner surface of the blood vessel (200). The anisotropic friction results in a surface propulsion of the tube (100), when the tube (100) is rotated around a central longitudinal body axis (106) of the tube (100). The tube (100) further comprises a magnetic material (108) distributed circumferentially around the tube (100) and configured for establishing within an external magnetic field a rotation of the tube (100) around the central longitudinal body axis (106) of the tube (100).

    METHOD FOR THE GENERATION OF OUTER RADIAL GLIAL (ORG) CELLS
    25.
    发明公开
    METHOD FOR THE GENERATION OF OUTER RADIAL GLIAL (ORG) CELLS 审中-公开

    公开(公告)号：EP4239061A1

    公开(公告)日：2023-09-06

    申请号：EP22160074.5

    申请日：2022-03-03

    申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

    发明人： The designation of the inventor has not yet been filed

    IPC分类号： C12N5/0793 ,  C12N5/079 ,  C12N5/0797

    摘要： The present invention relates to a method for the generation of outer radial glial (oRG) cells of the outer sub-ventricular (oSVZ)-like region in cerebral organoids comprising (a) culturing primate stem cells in a primate stem cell medium until about day 6, thereby inducing the formation of embryonic bodies; (b) culturing the embryonic bodies as obtained in step (a) in a neural induction medium until about day 11, thereby inducing the formation of organoids; wherein an inhibitor of TGF-β, an inhibitor of BMP and an inhibitor of WNT is present from about day 2 until about day 11; (c) embedding the organoids as obtained after steps (a) and (b) and if they display a size of at least 300 µm into a hydrogel that mimics the extracellular matrix (ECM), preferably Matrigel and culturing the organoids in a cerebral differentiation medium at least until about day 40, preferably at least until about day 60 and most preferably at least until about day 80, thereby obtaining cerebral organoids with oRG cells in oSVZ-like regions, wherein the organoids in step (c) are subjected to agitation from about day 15 onward, preferably by using an orbital shaker or a spinning bioreactor; and (d) optionally isolating one or more oRG cells from the oSVZ-like region.

    IMPROVED BIOLUMINESCENT SYSTEM
    30.
    发明公开
    IMPROVED BIOLUMINESCENT SYSTEM 审中-公开

    公开(公告)号：EP4183875A1

    公开(公告)日：2023-05-24

    申请号：EP21209450.2

    申请日：2021-11-22

    申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

    发明人： GREGOR, Carola

    IPC分类号： C12N9/02 ,  C12N9/10 ,  C12N15/63

    摘要： The present invention relates in a first aspect to an isolated nucleic acid molecule, comprising at least nucleic acid sequences encoding the luxC polypeptide with specific mutations compared to the wild type sequence as well as nucleic acid sequences encoding the luxD polypeptide containing amino acid substitutions as well as nucleotide derivatives thereof. Moreover, the polypeptides encoded are disclosed as well as operons, vectors and bacteriophages containing said nucleic acid sequences. In addition, cells in particular bacterial cells are provided containing the mutated luxC and luxD genes encoding the specific luxC and luxD polypeptides according to the present invention. Moreover, a method of generation of bright autobioluminescent cells is provided as well as kits comprising at least one isolated nucleic acid molecule according to the present invention or operons or vectors or bacteriophages. Finally, the use of molecules according to present inventions, proteins, operons, vectors and bacteriophages or cells in a process of bioluminescence imaging in living cells is provided.