公开(公告)号：EP3931354A1

公开(公告)日：2022-01-05

申请号：EP20717354.3

申请日：2020-02-27

申请人： 10X Genomics, Inc.

发明人： RAMACHANDRAN IYER, Eswar Prasad ,  MIKKELSEN, Tarjei Sigurd ,  TENTORI, Augusto Manuel ,  BHARADWAJ, Rajiv ,  STOECKIUS, Marlon ,  CHELL, James Michael ,  UYTINGCO, Cedric

IPC分类号： C12Q1/6841

公开(公告)号：EP3894591A2

公开(公告)日：2021-10-20

申请号：EP19839184.9

申请日：2019-12-06

申请人： 10X Genomics, Inc.

发明人： UYTINGCO, Cedric ,  BENT, Zachary ,  RAMACHANDRAN IYER, Eswar Prasad ,  VALDECANAS, Fernandino ,  FREY, Meghan L. F. ,  SHORT, Steven William ,  YIN, Yifeng ,  TENTORI, Augusto Manuel ,  BHARADWAJ, Rajiv ,  COX, David Maurice ,  CHEW, Jennifer ,  LUNDEBERG, Joakim ,  BAVA, Felice Alessio ,  KVASTAD, Linda ,  PRICE, Andrew D.

IPC分类号： C12Q1/6837 ,  C12Q1/6841

公开(公告)号：EP3889325A1

公开(公告)日：2021-10-06

申请号：EP21166784.5

申请日：2015-06-26

申请人： 10X Genomics, Inc.

发明人： HINDSON, Benjamin, J. ,  HINDSON, Christopher, Martin ,  SCHNALL-LEVIN, Michael ,  NESS, Kevin, Dean ,  JAROSZ, Mirna ,  SAXONOV, Serge ,  HARDENBOL, Paul ,  BHARADWAJ, Rajiv ,  ZHENG, Xinying ,  BELGRADER, Philip

IPC分类号： C40B20/04 ,  C40B50/16 ,  C12Q1/6806 ,  C12N15/10

摘要： Methods, compositions and systems for analyzing individual cells or cell populations through the partitioned analysis of contents of individual cells or cell populations. Individual cells or cell populations are co-partitioned with processing reagents for accessing cellular contents, and for uniquely identifying the contents of a given cell or cell population, and subsequently analyzing the cell's contents and characterizing it as having derived from an individual cell or cell population, including analysis and characterization of the cell's nucleic acids through sequencing.

公开(公告)号：EP3559272A1

公开(公告)日：2019-10-30

申请号：EP18836715.5

申请日：2018-11-16

申请人： 10X Genomics, Inc.

发明人： BHARADWAJ, Rajiv ,  SAXONOV, Serge

IPC分类号： C12Q1/6806 ,  G16B35/00 ,  G16B20/00

公开(公告)号：EP3298164A2

公开(公告)日：2018-03-28

申请号：EP16730074.8

申请日：2016-05-18

申请人： 10X Genomics, Inc.

发明人： PRICE, Andrew D. ,  HINDSON, Christopher ,  BHARADWAJ, Rajiv ,  KAUR, Sukhvinder ,  MCDERMOTT, Geoffrey

IPC分类号： C12Q1/68

CPC分类号： C12N15/1006 ,  C12Q1/6806 ,  C12Q1/6834 ,  C12Q2527/119 ,  C12Q2527/125 ,  C12Q2527/153 ,  C12Q2563/149 ,  C12Q2563/179 ,  C12Q2565/629 ,  C12Q2563/159

摘要： Compositions that include particle suspensions where such particle suspensions have characteristics for use in a variety of applications including, for example, flow restriction, reagent delivery, and use in microfluidic systems. In some compositions provided, the particle suspension include deformable particles and in particular compositions the deformable particles are beads or gel beads.

公开(公告)号：EP3161160A2

公开(公告)日：2017-05-03

申请号：EP15811911.5

申请日：2015-06-26

申请人： 10X Genomics, Inc.

发明人： HINDSON, Benjamin, J. ,  HINDSON, Christopher, Martin ,  SCHNALL-LEVIN, Michael ,  NESS, Kevin, Dean ,  JAROSZ, Mirna ,  SAXONOV, Serge ,  HARDENBOL, Paul ,  BHARADWAJ, Rajiv ,  ZHENG, Grace, X.y. ,  BELGRADER, Philip

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C12N15/1065

摘要： Methods, compositions and systems for analyzing individual cells or cell populations through the partitioned analysis of contents of individual cells or cell populations. Individual cells or cell populations are co-partitioned with processing reagents for accessing cellular contents, and for uniquely identifying the contents of a given cell or cell population, and subsequently analyzing the cell's contents and characterizing it as having derived from an individual cell or cell population, including analysis and characterization of the cell's nucleic acids through sequencing.

摘要翻译： 通过对单个细胞或细胞群的内容进行分区分析来分析个体细胞或细胞群的方法，组合物和系统。 单独的细胞或细胞群体与用于获取细胞内容物的处理试剂共同分配，并且用于唯一地鉴定给定细胞或细胞群体的内容物，随后分析细胞内容物并将其表征为源自单个细胞或细胞群体 包括通过测序分析和表征细胞核酸。

公开(公告)号：EP4214678A2

公开(公告)日：2023-07-26

申请号：EP21791150.2

申请日：2021-09-17

申请人： 10X Genomics, Inc.

发明人： TENTORI, Augusto Manuel ,  KIM, Hanyoup ,  XING, Siyuan ,  BAVA, Felice Alessio ,  BHARADWAJ, Rajiv ,  UYTINGCO, Cedric ,  GRAZIOSA, Erica

IPC分类号： G06T7/33 ,  C12Q1/6841 ,  C12Q1/6837

公开(公告)号：EP4212629A1

公开(公告)日：2023-07-19

申请号：EP22186351.7

申请日：2018-11-16

申请人： 10X Genomics, Inc.

发明人： BHARADWAJ, Rajiv ,  SAXONOV, Serge

IPC分类号： C12Q1/6806 ,  G16B35/00 ,  G16B20/00

摘要： Provided herein are methods and systems for processing a nucleic acid molecule from a biological particle (e.g., cell). A plurality of partitions (e.g., droplets) may be generated such that partitions of the plurality of partitions each include a biological particle (e.g., cell) comprising the nucleic acid molecule and a particle (e.g., bead). The partitions can be processed (e.g., imaged) to obtain one or more physical and/or optical properties of their respective biological particles. The nucleic acid molecules included in the partitions can be barcoded and sequenced (e.g., using nucleic acid barcode molecules coupled to the particles of the partitions) to generate nucleic acid sequences of the nucleic acid molecules. The nucleic acid sequences can be electronically associated with the one or more optical properties of the biological particles.

公开(公告)号：EP4144861A1

公开(公告)日：2023-03-08

申请号：EP22181577.2

申请日：2016-12-02

申请人： 10X Genomics, Inc.

发明人： ZHENG, Xinying ,  SAXONOV, Serge ,  SCHNALL-LEVIN, Michael ,  NESS, Kevin ,  BHARADWAJ, Rajiv

IPC分类号： C12Q1/68

摘要： The present invention is directed to methods, compositions and systems for analyzing sequence information while retaining structural and molecular context of that sequence information.

公开(公告)号：EP4053292A1

公开(公告)日：2022-09-07

申请号：EP21199180.7

申请日：2015-06-26

申请人： 10X Genomics, Inc.

发明人： HINDSON, Benjamin, J. ,  HINDSON, Christopher, Martin ,  SCHNALL-LEVIN, Michael ,  NESS, Kevin, Dean ,  JAROSZ, Mirna ,  SAXONOV, Serge ,  HARDENBOL, Paul ,  BHARADWAJ, Rajiv ,  ZHENG, Xinying ,  BELGRADER, Philip

IPC分类号： C12Q1/6806 ,  C12N15/10 ,  C40B20/04 ,  C40B50/16

摘要： Methods, compositions and systems for analyzing individual cells or cell populations through the partitioned analysis of contents of individual cells or cell populations. Individual cells or cell populations are co-partitioned with processing reagents for accessing cellular contents, and for uniquely identifying the contents of a given cell or cell population, and subsequently analyzing the cell's contents and characterizing it as having derived from an individual cell or cell population, including analysis and characterization of the cell's nucleic acids through sequencing.