公开(公告)号：EP2315751A1

公开(公告)日：2011-05-04

申请号：EP09770549.5

申请日：2009-06-26

申请人： Amgen Inc.

发明人： CHEN, Guoqing ,  CUSHING, Timothy, D. ,  FISHER, Benjamin ,  HE, Xiao ,  LI, Kexue ,  LI, Zhihong ,  MCGEE, Lawrence, R. ,  PATTAROPONG, Vatee ,  FAULDER, Paul ,  SEGANISH, Jennifer, L. ,  SHIN, Youngsook ,  WANG, Zhulun ,  LIU, Wen

IPC分类号： C07D213/82 ,  C07D233/88 ,  C07D407/08 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/06 ,  C07D487/10 ,  C07D487/16 ,  C07D491/10 ,  C07D495/10 ,  A61K31/506 ,  A61K31/404

CPC分类号： C07D413/14 ,  C07D213/82 ,  C07D233/88 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D407/08 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/06 ,  C07D487/10 ,  C07D487/16 ,  C07D491/10 ,  C07D495/10

摘要： Selected compounds are effective for prophylaxis and treatment of inflammation and inflammatory disorders, such as NIK-mediated disorders. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, inflammation and the like.

公开(公告)号：EP2132207A2

公开(公告)日：2009-12-16

申请号：EP08742272.1

申请日：2008-03-24

申请人： Amgen Inc.

发明人： CHEN, Yi ,  CUSHING, Timothy D. ,  HAO, Xiaolin ,  HE, Xiao ,  REICHELT, Andreas ,  RZASA, Robert M. ,  SEGANISH, Jennifer ,  SHIN, Youngsook ,  ZHANG, Dawei

IPC分类号： C07D471/04 ,  C07D487/04 ,  A61K31/4985 ,  A61P9/00 ,  A61P19/02 ,  A61P37/00 ,  A61P35/00

CPC分类号： C07D487/04 ,  C07D471/04 ,  C07D519/00

摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia ( T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

公开(公告)号：EP1556053A1

公开(公告)日：2005-07-27

申请号：EP03752410.5

申请日：2003-09-19

申请人： Amgen Inc.

发明人： BURKITT, Simon, A. ,  CARDOZO, Mario, G. ,  CUSHING, Timothy, D. ,  DEGRAFFENREID, Michael, R. ,  FARTHING, Christopher, N. ,  HAO, Xiaolin ,  JAEN, Juan, C. ,  JIAO, Xian, Yun ,  KOPECKY, David, J. ,  LABELLE, Marc ,  LIVELY, Sarah, E. ,  MCMINN, Dustin, L. ,  RASMUSSEN, Sven, P. ,  SHIN, Youngsook ,  SMITH, Andrew ,  SMITH, Marie-Louise

IPC分类号： A61K31/54

CPC分类号： C07D231/56 ,  C07D239/74 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  C07D495/14 ,  C07D513/04

摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic, infectious and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism, infection and cell proliferation. The subject compounds contain a fused heterobicyclic ring.