公开(公告)号：EP1677830B1

公开(公告)日：2012-10-17

申请号：EP04796039.8

申请日：2004-10-22

申请人： AMGEN INC.

发明人： NG, Gordon ,  LI, Yue-Sheng ,  GEGG, Colin, V. ,  ASKEW, JR., Benny, C. ,  STORZ, Thomas ,  LU, Yuelie ,  D'AMICO, Derin, C. ,  JAROSINSKI, Mark ,  LIU Chuan-Fa ,  HUANG, Qi

IPC分类号： A61K47/48 ,  C07K7/18 ,  A61P29/00

CPC分类号： A61K38/08 ,  A61K38/10 ,  C07K7/06 ,  C07K7/08 ,  C07K7/18

公开(公告)号：EP1971604A2

公开(公告)日：2008-09-24

申请号：EP06826602.2

申请日：2006-10-23

申请人： Amgen Inc.

发明人： GERMAIN, Julie ,  ASKEW, Benny, C., Jr. ,  BAUER, David ,  CHOQUETTE, Deborah ,  DIPIETRO, Lucian, V. ,  GRACEFFA, Russell ,  HARMANAGE, Jean-Christophe ,  HUANG, Qi ,  KIM, Joseph, L. ,  LA, Daniel ,  LI, Aiwen ,  NISHIMURA, Nobuko ,  NOMAK, Rana ,  PATEL, Vinod ,  POTASHMAN, Michele ,  RIAHI, Babak ,  STORZ, Thomas ,  VAN DER PLAS, Simon ,  YANG, Kevin ,  YUAN, Chester, C.

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC分类号： C07D471/04 ,  C07D487/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1507776A1

公开(公告)日：2005-02-23

申请号：EP03741829.0

申请日：2003-05-29

申请人： Amgen Inc.

发明人： HUANG, Qi ,  KALLER, Matthew ,  NGUYEN, Thomas ,  NORMAN, Mark, H. ,  RZASA, Robert ,  WANG, Hui-Ling ,  ZHONG, Wenge

IPC分类号： C07D417/14 ,  C07D403/04 ,  C07D491/04 ,  C07D417/04 ,  C07D409/14 ,  C07D513/04 ,  C07D471/04 ,  A61K31/505 ,  A61P25/00 ,  A61P35/00

CPC分类号： C07D403/04 ,  C07D409/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D491/04 ,  C07D513/04

摘要： Compounds of formula (I) are effective for treatment of cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stroke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1240158A1

公开(公告)日：2002-09-18

申请号：EP00984165.1

申请日：2000-12-11

申请人： Amgen Inc.,

发明人： DOMINGUEZ, Celia ,  CHEN, Guoqing ,  XI, Ning ,  XU, Shimin ,  HAN, Nianhe ,  LIU, Qingyian ,  HUANG, Qi ,  SIEGMUND, Aaron ,  HANDLEY, Michael ,  LIU, Longbin ,  KISELYOV, Alexander S.

IPC分类号： C07D401/12 ,  C07D417/14 ,  C07D401/14 ,  C07D407/14 ,  C07D409/12 ,  C07D207/277 ,  A61K31/4025 ,  A61P19/00 ,  A61P35/00

CPC分类号： C07D207/277 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D417/14

摘要： The invention comprises novel compounds that are effective in the prophylaxis and treatment of diseases, such as integrin receptors mediated diseases, in particular, diseases or conditions mediated by integrin receptors, such as αvβ3, αvβ5, αvβ6, α5β1 and the like. The invention encompasses novel compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of such diseases and disorders. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.