公开(公告)号：EP1240158A1

公开(公告)日：2002-09-18

申请号：EP00984165.1

申请日：2000-12-11

申请人： Amgen Inc.,

发明人： DOMINGUEZ, Celia ,  CHEN, Guoqing ,  XI, Ning ,  XU, Shimin ,  HAN, Nianhe ,  LIU, Qingyian ,  HUANG, Qi ,  SIEGMUND, Aaron ,  HANDLEY, Michael ,  LIU, Longbin ,  KISELYOV, Alexander S.

IPC分类号： C07D401/12 ,  C07D417/14 ,  C07D401/14 ,  C07D407/14 ,  C07D409/12 ,  C07D207/277 ,  A61K31/4025 ,  A61P19/00 ,  A61P35/00

CPC分类号： C07D207/277 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D417/14

摘要： The invention comprises novel compounds that are effective in the prophylaxis and treatment of diseases, such as integrin receptors mediated diseases, in particular, diseases or conditions mediated by integrin receptors, such as αvβ3, αvβ5, αvβ6, α5β1 and the like. The invention encompasses novel compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of such diseases and disorders. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1519921A2

公开(公告)日：2005-04-06

申请号：EP03763451.6

申请日：2003-07-09

申请人： Amgen Inc.

发明人： HUANG, Qi ,  CHEN, Guoqing ,  LI, Aiwen ,  RIAHI, Babak ,  TASKER, Andrew ,  YANG, Kevin ,  YUAN, Chester, Chenguang

IPC分类号： C07D213/36

CPC分类号： C07D401/12 ,  C07D209/20 ,  C07D213/36 ,  C07D215/12 ,  C07D217/02 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D471/12 ,  C07D487/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1358184A1

公开(公告)日：2003-11-05

申请号：EP02717325.1

申请日：2002-01-11

申请人： Amgen Inc.

发明人： CHEN, Guoqing ,  ADAMS, Jeffrey ,  BEMIS, Jean ,  BOOKER, Shon ,  CAI, Guolin ,  CROGHAN, Michael ,  DIPIETRO, Lucian ,  DOMINGUEZ, Celia ,  ELBAUM, Daniel ,  GERMAIN, Julie ,  GEUNS-MEYER, Stephanie ,  HANDLEY, Michael ,  HUANG, Qi ,  KIM, Joseph, L. ,  KIM, Tae-Seong ,  KISELYOV, Alexander ,  OUYANG, Xiaohu ,  PATEL, Vinod, F. ,  SMITH, Leon, M. ,  STEC, Markian ,  TASKER, Andrew ,  XI, Ning ,  XU, Shimin ,  YUAN, Chester Chenguang

IPC分类号： C07D409/12 ,  C07D409/14 ,  C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D409/04 ,  C07D413/14 ,  C07D417/14 ,  C07D405/14 ,  C07D405/12

CPC分类号： C07D213/82 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/00 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1537084B1

公开(公告)日：2013-08-21

申请号：EP03764794.8

申请日：2003-07-15

申请人： AMGEN INC.

发明人： ASKEW JR, Benny C. ,  ADAMS, Jeffrey ,  BOOKER, Shon ,  CHEN, Guoqing ,  DIPIETRO, Lucian, V. ,  ELBAUM, Daniel ,  GERMAIN, Julie ,  GEUNS-MEYER, Stephanie, D. ,  HABGOOD, Gregory, J. ,  HANDLEY, Michael ,  HUANG, Qi ,  KIM, Tae-Seong ,  LI, Aiwen ,  NISHIMURA, Nobuko ,  NOMAK, Rana, Bogazici University ,  PATEL, Vinod, F. ,  RIAHI, Babak ,  KIM, Joseph, L. ,  XI, Ning ,  YUAN, Chester, Chenguang

IPC分类号： C07D213/82 ,  C07D401/12 ,  C07D417/12 ,  C07D471/04 ,  A61K31/44 ,  A61P19/00 ,  A61P35/00

CPC分类号： C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

公开(公告)号：EP1562933A2

公开(公告)日：2005-08-17

申请号：EP03764755.9

申请日：2003-07-15

申请人： Amgen Inc.

发明人： PATEL, Vinod, F. ,  ASKEW JR, Benny, C. ,  BOOKER, Shon ,  CHEN, Guoqing ,  DIPIETRO, Lucian, V. ,  GERMAIN, Julie ,  HABGOOD, Gregory, J. ,  HUANG, Qi ,  KIM, Tae-Seong ,  LI, Aiwen ,  NISHIMURA, Nobuko ,  NOMAK, Rana ,  RIAHI, Babak ,  YUAN, Chester, Chenguang ,  ELBAUM, Daniel

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D417/14 ,  C07D405/14 ,  C07D407/14 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4433 ,  C07D413/14

CPC分类号： C07D471/04 ,  A61K31/00 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14

摘要： Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1537084A1

公开(公告)日：2005-06-08

申请号：EP03764794.8

申请日：2003-07-15

申请人： Amgen Inc.

发明人： ASKEW JR, Benny C. ,  ADAMS, Jeffrey ,  BOOKER, Shon ,  CHEN, Guoqing ,  DIPIETRO, Lucian, V. ,  ELBAUM, Daniel ,  GERMAIN, Julie ,  GEUNS-MEYER, Stephanie, D. ,  HABGOOD, Gregory, J. ,  HANDLEY, Michael ,  HUANG, Qi ,  KIM, Tae-Seong ,  LI, Aiwen ,  NISHIMURA, Nobuko ,  NOMAK, Rana ,  PATEL, Vinod, F. ,  RIAHI, Babak ,  KIM, Joseph, L. ,  XI, Ning ,  YUAN, Chester, Chenguang

IPC分类号： C07D213/82 ,  C07D401/12 ,  C07D417/12 ,  C07D471/04 ,  A61K31/44 ,  A61P19/00 ,  A61P35/00

CPC分类号： C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： Selected amines of Formula XIII, which are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 选择的式ⅩⅢ胺有效预防和治疗疾病，如血管生成介导的疾病。 本发明包括新化合物，类似物，前药和药学上可接受的盐，用于预防和治疗涉及癌症等的疾病和其他疾病或病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及用于这些方法的中间体。

公开(公告)号：EP2315751A1

公开(公告)日：2011-05-04

申请号：EP09770549.5

申请日：2009-06-26

申请人： Amgen Inc.

发明人： CHEN, Guoqing ,  CUSHING, Timothy, D. ,  FISHER, Benjamin ,  HE, Xiao ,  LI, Kexue ,  LI, Zhihong ,  MCGEE, Lawrence, R. ,  PATTAROPONG, Vatee ,  FAULDER, Paul ,  SEGANISH, Jennifer, L. ,  SHIN, Youngsook ,  WANG, Zhulun ,  LIU, Wen

IPC分类号： C07D213/82 ,  C07D233/88 ,  C07D407/08 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/06 ,  C07D487/10 ,  C07D487/16 ,  C07D491/10 ,  C07D495/10 ,  A61K31/506 ,  A61K31/404

CPC分类号： C07D413/14 ,  C07D213/82 ,  C07D233/88 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D407/08 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/06 ,  C07D487/10 ,  C07D487/16 ,  C07D491/10 ,  C07D495/10

摘要： Selected compounds are effective for prophylaxis and treatment of inflammation and inflammatory disorders, such as NIK-mediated disorders. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, inflammation and the like.

公开(公告)号：EP1358184B1

公开(公告)日：2007-05-02

申请号：EP02717325.1

申请日：2002-01-11

申请人： AMGEN INC.

发明人： CHEN, Guoqing ,  ADAMS, Jeffrey ,  BEMIS, Jean ,  BOOKER, Shon ,  CAI, Guolin ,  CROGHAN, Michael ,  DIPIETRO, Lucian ,  DOMINGUEZ, Celia ,  ELBAUM, Daniel ,  GERMAIN, Julie ,  GEUNS-MEYER, Stephanie ,  HANDLEY, Michael ,  HUANG, Qi ,  KIM, Joseph, L. ,  KIM, Tae-Seong ,  KISELYOV, Alexander ,  OUYANG, Xiaohu ,  PATEL, Vinod, F. ,  SMITH, Leon, M. ,  STEC, Markian ,  TASKER, Andrew ,  XI, Ning ,  XU, Shimin ,  YUAN, Chester Chenguang

IPC分类号： C07D401/14

CPC分类号： C07D213/82 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/00 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1358161A2

公开(公告)日：2003-11-05

申请号：EP02717324.4

申请日：2002-01-11

申请人： Amgen Inc.

发明人： CHEN, Guoqing ,  BOOKER, Shon ,  CAI, Guolin ,  CROGHAN, Michael ,  DIPIETRO, Lucian ,  DOMINGUEZ, Celia ,  ELBAUM, Daniel ,  GERMAIN, Julie ,  HUANG, Qi ,  KIM, Joseph, L. ,  KIM, Tae-Seong ,  PATEL, Vinod, F. ,  SMITH, Leon, M. ,  TASKER, Andrew ,  XI, Ning ,  XU, Shimin ,  YUAN, Chester, Chenguang

IPC分类号： C07D213/81 ,  C07D213/82 ,  C07D401/12 ,  C07D405/12 ,  C07D401/14 ,  C07D413/12 ,  A61K31/44 ,  A61P19/00 ,  A61P35/00

CPC分类号： C07D213/81 ,  C07D213/82 ,  C07D237/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04

摘要： Selected compounds of formula (I), wherein each of A?1 and A2¿ is independently C or N; wherein A1-A2 form part of a ring A selected from 5- or 6- membered heteroaryl; wherein X is; wherein Z is oxygen or sulfur; are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1562933B1

公开(公告)日：2008-03-19

申请号：EP03764755.9

申请日：2003-07-15

申请人： AMGEN INC.

发明人： PATEL, Vinod, F. ,  ASKEW JR, Benny, C. ,  BOOKER, Shon ,  CHEN, Guoqing ,  DIPIETRO, Lucian, V. ,  GERMAIN, Julie ,  HABGOOD, Gregory, J. ,  HUANG, Qi ,  KIM, Tae-Seong ,  LI, Aiwen ,  NISHIMURA, Nobuko ,  NOMAK, Rana ,  RIAHI, Babak ,  YUAN, Chester, Chenguang ,  ELBAUM, Daniel

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D417/14 ,  C07D405/14 ,  C07D407/14 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4433 ,  C07D413/14

CPC分类号： C07D471/04 ,  A61K31/00 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14

摘要： Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.