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公开(公告)号：EP1940452B1
公开(公告)日：2012-11-21
申请号：EP06826442.3
申请日：2006-10-20
申请人： Amgen, Inc
发明人： GEGG, Colin, V., Jr. , MIRANDA, Leslie, P. , WALKER, Kenneth, W. , JOHNSON, Eileen, J. , HOLDER, Jerry, Ryan , WRIGHT, Marie, E. , D'AMICO, Derin, C.
IPC分类号： A61K38/22 , C07K14/575 , A61P25/06
CPC分类号： A61K38/225 , C07K14/57527
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公开(公告)号：EP1940452A2
公开(公告)日：2008-07-09
申请号：EP06826442.3
申请日：2006-10-20
申请人： Amgen, Inc
发明人： GEGG, Colin, V., Jr. , MIRANDA, Leslie, P. , WALKER, Kenneth, W. , JOHNSON, Eileen, J. , HOLDER, Jerry, Ryan , WRIGHT, Marie, E. , D'AMICO, Derin, C.
IPC分类号： A61K38/22 , C07K14/575 , A61P25/06
CPC分类号： A61K38/225 , C07K14/57527
摘要： Disclosed is a composition of matter that involves a CGRP peptide antagonist. A pharmaceutical composition is disclosed that comprises the composition of matter and a pharmaceutically acceptable carrier, which can be configured for administration to a patient. Also disclosed is a method of producing the composition of matter. Methods of treating, preventing or mitigating migraine, are also disclosed.
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公开(公告)号：EP1817306A1
公开(公告)日：2007-08-15
申请号：EP05813304.2
申请日：2005-10-11
申请人： Amgen, Inc
发明人： AYA, Toshihiro , CAI, Guolin , CHEN, Jian, J. , D'AMICO, Derin, C. , NGUYEN, Thomas , QIAN, Wenyuan
IPC分类号： C07D403/06 , A61K31/497 , A61K31/4192 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D471/04
CPC分类号： C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D471/04
摘要： Compounds of Formula (I): are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
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公开(公告)号：EP1677830B1
公开(公告)日：2012-10-17
申请号：EP04796039.8
申请日：2004-10-22
申请人： AMGEN INC.
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公开(公告)号：EP1656355B1
公开(公告)日：2008-03-12
申请号：EP04820712.0
申请日：2004-06-21
申请人： AMGEN INC.
发明人： CHEN, Jian, J. , ASKEW, Ben, C. , BISWAS, Kaustav , CHAU, Jennifer, N. , D'AMICO, Derin, C. , HARRIED, Scott , NGUYEN, Thomas , QIAN, Wenyuan , ZHU, Jiawang , FOTSCH, Christopher, H. , HAN, Nianhe , LI, Aiwen , LIU, Qingyian , NISHIMURA, Nobuko , NOMAK, Rana , PETERKIN, Tanya , RIAHI, Babak , YANG, Kevin , YUAN, Chester, Chenguang
IPC分类号： A61K31/495 , C07D241/08 , C07D243/08 , C07D245/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
CPC分类号： C07D241/08 , C07D243/08 , C07D245/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14
摘要： Compounds (I) are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
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公开(公告)号：EP1677830A2
公开(公告)日：2006-07-12
申请号：EP04796039.8
申请日：2004-10-22
申请人： AMGEN INC.
发明人： NG, Gordon , LI, Yue-Sheng , GEGG, Colin, V. , ASKEW, JR., Benny, C. , STORZ, Thomas , LU, Yuelie , D'AMICO, Derin, C.
摘要： The present invention relates to certain biologically active peptides and conjugated peptides which can be used as therapeutics or prophylactics against diseases or conditions linked to B1 as the causative agent. In a preferred embodiment of the invention biologically active PEG-conjugated peptides are provided. In one aspect of the present invention, pharmacologically active PEG-conjugated peptides of the present invention are useful to treat inflammation or pain.
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