公开(公告)号：EP2111389A1

公开(公告)日：2009-10-28

申请号：EP08701608.5

申请日：2008-01-21

申请人： BASF SE

发明人： MAYWALD, Volker ,  OTT, Christian ,  WOLF, Bernd ,  EHRESMANN, Manfred ,  RACK, Michael ,  KEIL, Michael ,  SMIDT, Sebastian, Peer

IPC分类号： C07C67/343 ,  C07C69/65 ,  C07C17/12 ,  C07C25/13

CPC分类号： C07C17/12 ,  C07C67/343 ,  C07C25/13 ,  C07C69/65

摘要： The present invention relates to a method for the production of substituted 2-aryl malonic acid esters of the general formula (I), wherein R stands for C1-C6-alkyl or C1-C4-alkoxy-C1-C4-alkyl; Ar stands for phenyl or a heteroaromatic 5-member or 6-member ring; wherein each C atom contained in the above-named groups potentially carries a substituent RA; RA stands for F, C1, CN, NO2, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, etc., or two adjacent substituents RA form a ring together with the carbon atoms to which they are bound; and wherein a malonic acid ester is converted with a base and an aryl bromide in the presence of a copper salt, characterized in that 0.1 to 0.65 mole equivalents of the base are substituted for 1 mole equivalent of the malonic acid ester.

公开(公告)号：EP2086944A1

公开(公告)日：2009-08-12

申请号：EP07822162.9

申请日：2007-11-02

申请人： BASF SE

发明人： RACK, Michael ,  SMIDT, Sebastian Peer ,  LÖHR, Sandra ,  KEIL, Michael ,  DIETZ, Jochen ,  RHEINHEIMER, Joachim ,  GROTE, Thomas ,  ZIERKE, Thomas ,  LOHMANN, Jan Klaas ,  SUKOPP, Martin

IPC分类号： C07D237/04 ,  C07F7/04

CPC分类号： C07D231/14

摘要： The present invention relates to a process for preparing difluoromethyl-substituted pyrazol-4-yl carboxylates of the formula (I) in which R1 is C1-C8-alkyl, C3-C8-cycloalkyl, C1-C4-alkoxy-C1-C4-alkyl, etc.; and R2 is hydrogen, C1-C4-alkyl, benzyl or phenyl, wherein a) a compound of the general formula (II) in which X is fluorine, chlorine, or bromine, R1 has one of the definitions given above, and R4 is C1-C8-alkyl, C3-C8-cycloalkyl, C2-C8-alkenyl, benzyl or phenyl, is reacted with a silane compound of the general formula R3nSiCl(4-n) in which n is 1, 2 or 3 and the substituents R3 are each independently selected from C1-C8-alkyl and phenyl, and with a metal which is selected from the metals of groups 1, 2, 3, 4 and 12 of the periodic table and has a redox potential of less than -0.7 V, based on a standard hydrogen electrode (at 25°C and 101.325 kPa); and b) the reaction mixture from step a) is reacted with a compound of the general formula (III) in which R2 has one of the definitions given above.

摘要翻译： 本发明涉及制备式（I）的二氟甲基取代的吡唑-4-基羧酸酯的方法，其中R 1是C 1 -C 8烷基，C 3 -C 8环烷基，C 1 -C 4烷氧基-C 1 -C 4烷基， 烷基等; 其中a）通式（II）的化合物，其中X是氟，氯或溴，R1具有上述定义之一，且R4是氢，C1-C4-烷基，苄基或苯基， C1-C8-烷基，C3-C8-环烷基，C2-C8-链烯基，苄基或苯基与通式R3nSiCl（4-n）的硅烷化合物反应，其中n是1,2或3， R3各自独立地选自C1-C8-烷基和苯基，并且与选自元素周期表第1,2,3,4和12族的金属的金属并且具有小于-0.7V的氧化还原电势 ，基于标准氢电极（在25℃和101.325kPa下）; 和b）将来自步骤a）的反应混合物与通式（III）的化合物反应，其中R 2具有上述定义之一。

公开(公告)号：EP2084137A1

公开(公告)日：2009-08-05

申请号：EP07822223.9

申请日：2007-11-05

申请人： BASF SE

发明人： SUKOPP, Martin ,  KUHN, Oliver ,  GRÖNING, Carsten ,  KEIL, Michael ,  LONGLET, Jon J.

IPC分类号： C07D231/44 ,  A01N43/56 ,  A01N43/00 ,  A61K31/415 ,  A61P33/00

CPC分类号： C07D231/44 ,  A01N43/56 ,  A01N47/02

摘要： The present invention relates to a process for the sulfinylation of a pyrazole derivative, characterized in that 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonitrile (II) is reacted with a sulfinylating agent S in the presence of at least one amine acid complex wherein the amine(s) are selected from secondary and/or tertiary amines and the acid(s) are selected from hydrofluoric, hydrochloric, hydrobromic and hydroiodic acid and sulfonic acid derivatives, and with the addition of a halogenating agent, wherein S is [CF3S(O)]2O; or CF3S(O)X wherein X means fluoro, chloro, bromo, iodo, a hydroxy group, or an alkaline or alkaline earth metal salt of the hydroxy group; or mixtures thereof, wherein the temperature of the reaction mixture at no time exceeds 39°C.

摘要翻译： 本发明涉及吡唑衍生物的亚磺酰化方法，其特征在于5-氨基-1- [2,6-二氯-4-（三氟甲基）苯基] -1H-吡唑-3-甲腈（II）为 在至少一种胺酸络合物存在下与亚磺酰化剂S反应，其中所述胺选自仲胺和/或叔胺并且所述酸选自氢氟酸，盐酸，氢溴酸和氢碘酸以及磺酸 酸衍生物，并加入卤化剂，其中S是[CF 3 S（O）] 2 O; 或CF 3 S（O）X，其中X表示氟，氯，溴，碘，羟基或羟基的碱金属或碱土金属盐; 或其混合物，其中反应混合物的温度不超过39℃。

公开(公告)号：EP2081914A2

公开(公告)日：2009-07-29

申请号：EP07821246.1

申请日：2007-10-12

申请人： BASF SE

发明人： SCHMIDT, Thomas ,  GEBHARDT, Joachim ,  LÖHR, Sandra ,  KEIL, Michael ,  WEVERS, Jan Hendrik ,  ERK, Peter ,  SAXELL, Heidi Emilia ,  HAMPRECHT, Gerhard ,  SEITZ, Werner ,  MAYER, Guido ,  WOLF, Bernd ,  COX, Gerhard ,  MICHEL, Alfred ,  ZAGAR, Cyrill ,  REINHARD, Robert ,  SIEVERNICH, Bernd

IPC分类号： C07D239/54 ,  A01N43/48

CPC分类号： C07D239/54

摘要： The present invention relates to a crystalline form of 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1-(2H)-pyrimidinyl]-4-fluoro-N-[[methyl-(1-methylethyl)amino]sulphonyl]benzamide. The invention also relates to a method for preparing this crystalline form and to formulations for crop protection which comprise this crystalline form of the phenyluracil.

公开(公告)号：EP1419134B1

公开(公告)日：2008-07-16

申请号：EP02794543.5

申请日：2002-08-02

申请人： BASF SE

发明人： KUDIS, Steffen ,  LOCHTMAN, Rene ,  EHRESMANN, Manfred ,  KEIL, Michael ,  GEBHARDT, Joachim ,  RACK, Michael ,  SCHIMETZEK, Ralf

IPC分类号： C07C201/04 ,  C07C203/00

CPC分类号： C07C201/04 ,  C07C203/00

摘要： The invention relates to a continuous method for producing alkyl nitrites and alkyl dinitrites. According to said method, (i) an alkanol or dialkanol is mixed with an aqueous solution of a mineral acid, whereby on average no more than 1.01 mol acid equivalents per mol hydroxyl group of alkanol or dialkanol is used, (ii) in a reaction zone, an aqueous solution of an inorganic nitrite is continuously added to the aqueous mixture obtained in step (i), (iii) the organic phase is optionally isolated.

公开(公告)号：EP1893586A1

公开(公告)日：2008-03-05

申请号：EP06755248.9

申请日：2006-05-18

申请人： BASF SE

发明人： GEBHARDT, Joachim ,  LÖHR, Sandra ,  KEIL, Michael ,  SCHMIDT, Thomas ,  WEVERS, Jan Hendrik ,  ZECH, Helmut ,  HÄBERLE, Rudolf

IPC分类号： C07D239/54

CPC分类号： C07D239/54

摘要： The invention relates to a method for production of 1-alkyl-3- phenyluracils of formula (I), where the variables R1 to R7 have the meanings given in the description, whereby 3-phenyluracils of formula (II) and alkylating agents of formula (III) are reacted together, characterised in that during the complete reaction the pH is maintained in the range of 1 to 6 by portioned addition of base.

摘要翻译： 本发明涉及制备式（I）的1-烷基-3-苯基尿嘧啶的方法，其中变量R 1至R 7具有说明书中给出的含义，由此式（II）的3-苯基尿嘧啶和式 （III）一起反应，其特征在于在完全反应期间，通过分批加入碱将pH保持在1至6的范围内。

公开(公告)号：EP2262756B1

公开(公告)日：2016-08-31

申请号：EP09715410.8

申请日：2009-02-27

申请人： BASF SE

发明人： MAYWALD, Volker ,  SMIDT, Sebastian, Peer ,  WOLF, Bernd ,  KORADIN, Christopher ,  ZIERKE, Thomas ,  RACK, Michael ,  KEIL, Michael

IPC分类号： C07C67/343 ,  C07C69/72 ,  C07D231/14

CPC分类号： C07D231/14 ,  C07C67/343 ,  C07C69/72

公开(公告)号：EP2802566B1

公开(公告)日：2016-03-16

申请号：EP12809180.8

申请日：2012-12-13

申请人： BASF SE

发明人： KEIL, Michael ,  REICHERT, Wolfgang ,  KORADIN, Christopher ,  BATTAL, Yüksel

IPC分类号： C07D231/12

CPC分类号： C07D231/12 ,  C07C211/48

公开(公告)号：EP2585436B1

公开(公告)日：2015-03-18

申请号：EP11797708.2

申请日：2011-06-20

申请人： BASF SE

发明人： MAYWALD, Volker ,  MENGES, Frederik ,  VOGELBACHER, Uwe Josef ,  RACK, Michael ,  KEIL, Michael ,  GRAMMENOS, Wassilios ,  VRETTOU-SCHULTES, Marianna ,  LOHMANN, Jan Klaas ,  MÜLLER, Bernd ,  JABS, Thorsten

IPC分类号： C07D213/08 ,  C07D213/61 ,  C07D213/68

CPC分类号： C07D213/68 ,  C07D213/08 ,  C07D213/61

公开(公告)号：EP2794579A1

公开(公告)日：2014-10-29

申请号：EP12812627.3

申请日：2012-12-20

申请人： BASF SE

发明人： WOLF, Bernd ,  GEBHARDT, Joachim ,  VOGELBACHER, Uwe Josef ,  DOCHNAHL, Maximilian ,  RACK, Michael ,  KEIL, Michael ,  FRASSETTO, Timo ,  MAYWALD, Volker

IPC分类号： C07D265/36 ,  C07D413/04

CPC分类号： C07D265/36 ,  C07D413/04

摘要： The present invention relates to a process for manufacturing 4-substituted amino- benzoxazinones of formula (I), by reacting a NH-benzoxazinone of formula (II) with a compound of formula (III); wherein the variables are defined according to the description.