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公开(公告)号：EP3331611A1
公开(公告)日：2018-06-13
申请号：EP16748101.9
申请日：2016-08-01
IPC分类号： A61P35/00 , A61K31/506 , A61K31/444 , A61K31/4439 , C07D401/14 , C07D405/14 , C07D401/04 , C07D403/04 , C07D409/14 , C07D417/14 , C07D471/04 , C07D491/056
CPC分类号： C07D401/04 , A61K31/4439 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/056
摘要： Compounds of formula (I) as described herein, processes for their production and their use as pharmaceuticals.
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公开(公告)号：EP3310775A1
公开(公告)日：2018-04-25
申请号：EP16734202.1
申请日：2016-06-14
发明人： GRAHAM, Keith , KLAR, Ulrich , BRIEM, Hans , SIEMEISTER, Gerhard , MÖNNING, Ursula , BALINT, Jozsef
IPC分类号： C07D401/14 , C07D405/14 , C07D401/04 , C07D403/04 , C07D409/14 , C07D417/14 , C07D471/04 , C07D491/056 , A61K31/4439 , A61K31/444 , A61K31/506 , A61P35/00
摘要： Compounds of formula (I) as described hereinprocesses for their production and their use as anti-cancer agents.
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公开(公告)号：EP3157914A1
公开(公告)日：2017-04-26
申请号：EP15730130.0
申请日：2015-06-17
发明人： GRAHAM, Keith , KLAR, Ulrich , BRIEM, Hans , HITCHCOCK, Marion , BÄRFACKER, Lars , EIS, Knut , SCHULZE, Volker , SIEMEISTER, Gerhard , BONE, Wilhelm , SCHRÖDER, Jens , HOLTON, Simon , LIENAU, Philip , TEMPEL, René , SONNENSCHEIN, Helmut , BÁLINT, Jozsef , GRAUBAUM, Heinz
IPC分类号： C07D401/14 , C07D405/14 , C07D401/04 , C07D403/04 , C07D409/14 , C07D417/14 , C07D471/04 , C07D491/056 , A61K31/4439 , A61K31/444 , A61K31/506 , A61P35/00
CPC分类号： C07D401/04 , A61K31/436 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/4725 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D491/056
摘要： Compounds of formula (I) which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.
摘要翻译： 作为Bub1激酶抑制剂的式（I）化合物，其制备方法及其作为药物的用途。
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公开(公告)号：EP2825540B1
公开(公告)日：2016-09-14
申请号：EP13710986.4
申请日：2013-03-11
发明人： KOPPITZ, Marcus , KLAR, Ulrich , WENGNER, Antje Margret , NEUHAUS, Roland , SIEMEISTER, Gerhard
IPC分类号： C07D487/04 , A61K31/5025 , A61P35/00
CPC分类号： C07D487/04 , A61K31/5025 , A61K45/06
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公开(公告)号：EP2951175A1
公开(公告)日：2015-12-09
申请号：EP14701580.4
申请日：2014-01-29
发明人： KLAR, Ulrich , WORTMANN, Lars , KETTSCHAU, Georg , PÜHLER, Florian , LIENAU, Philip , SÜLZLE, Detlev
IPC分类号： C07D471/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04 , A61K31/519 , A61K45/06 , C07D471/04
摘要： The present invention relates to substituted pyrazolopyrimidinylamino-indazole compounds of general formula I as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及本文所述和定义的通式I的取代的吡唑并嘧啶基氨基 - 吲唑化合物，制备所述化合物的方法，可用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合，以及所述 用于制造用于治疗或预防疾病，特别是高增殖和/或血管生成障碍的药物组合物作为唯一试剂或与其它活性成分组合的化合物。
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公开(公告)号：EP2825540A1
公开(公告)日：2015-01-21
申请号：EP13710986.4
申请日：2013-03-11
发明人： KOPPITZ, Marcus , KLAR, Ulrich , WENGNER, Antje Margret , NEUHAUS, Roland , SIEMEISTER, Gerhard
IPC分类号： C07D487/04 , A61K31/5025 , A61P35/00
CPC分类号： C07D487/04 , A61K31/5025 , A61K45/06
摘要： The present invention relates to substituted imidazopyridazine compounds of general formula I in which R
3 , R
5 and A are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.-
27.发明公开17-HYDROXY-17-PENTAFLUORETHYL-ESTRA-4,9 (10)-DIEN-11-ACYLOXYALKYLENPHENYL-DERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ZUR BEHANDLUNG VON KRANKHEITEN 有权17-羟基-17-五氟乙基 - 雌-4,9（10） - 二烯-11- ACYLOXYALKYLENPHENYL衍生物，METHOD用于产生和将其用于疾病治疗
公开(公告)号：EP2456781A2
公开(公告)日：2012-05-30
申请号：EP10730384.4
申请日：2010-07-07
IPC分类号： C07J7/00
CPC分类号： C07J1/0081 , A61K31/573 , A61K31/58 , C07J7/0085 , C07J41/0044 , C07J41/0083 , C07J43/003
摘要： The invention relates to 17-hydroxy-13-methyl-17-pentafluorethyl-11-acyloxyalkylenephenyl-dodecahydro-cyclopenta[a]phenanthrene-3-on derivatives of formula (I) exhibiting progesterone-antagonistic effects and to methods for the production thereof, to the use thereof for the treatment and/or prophylaxis of diseases and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases, in particular uterine fibroids (myomas, uterine leiomyomas), endometriosis, menorrhagia, meningiomas, hormone-dependent mammary carcinomas and menopause-associated troubles, or for fertility control and emergency contraception.
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28.发明公开17-HYDROXY-17-PENTAFLUORETHYL-ESTRA-4,9(10)-DIEN-11-METHYLENOXYALKYLENARYL-DERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ZUR BEHANDLUNG VON KRANKHEITEN 有权17-羟基-17-五氟乙基 - 雌-4,9（10） - 二烯-11- METHYLENOXYALKYLENARYL衍生物，METHOD用于产生和将其用于疾病治疗
公开(公告)号：EP2456779A2
公开(公告)日：2012-05-30
申请号：EP10739294.6
申请日：2010-07-07
IPC分类号： C07J1/00
CPC分类号： C07J1/0081 , A61K31/573 , C07J7/0085 , C07J41/0083 , C07J41/0094 , C07J43/003
摘要： The invention relates to a 17-hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11methylene oxyalkylene aryl derivative of formula (I) exhibiting progesterone-antagonistic effects and to methods for the production thereof, to the use thereof for the treatment and/or prophylaxis of diseases and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases, in particular uterine fibroids (myomas, uterine leiomyomas), endometriosis, menorrhagia, meningiomas, hormone-dependent mammary carcinomas and menopause-associated troubles, or for fertility control and emergency contraception.
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公开(公告)号：EP3250567B1
公开(公告)日：2019-10-30
申请号：EP16701600.5
申请日：2016-01-25
发明人： GRAHAM, Keith , KLAR, Ulrich , BRIEM, Hans , SCHULZE, Volker , SIEMEISTER, Gerhard , LIENAU, Philip , TEMPEL, René , BÁLINT, Jozsef
IPC分类号： C07D405/14 , C07D401/12 , C07D471/04 , A61K31/437 , A61P35/00
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公开(公告)号：EP2951175B1
公开(公告)日：2017-10-04
申请号：EP14701580.4
申请日：2014-01-29
发明人： KLAR, Ulrich , WORTMANN, Lars , KETTSCHAU, Georg , PÜHLER, Florian , LIENAU, Philip , SÜLZLE, Detlev
IPC分类号： C07D471/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04 , A61K31/519 , A61K45/06 , C07D471/04
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