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21.发明公开
公开(公告)号：EP3725810A1
公开(公告)日：2020-10-21
申请号：EP20163993.7
申请日：2013-05-21
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , MITNACHT-KRAUS, Rita , JACOBS, Stefan Denis , UTSCH, Magdalena Jadwiga , HEINZ, Cornelia Adriana Maria , STADLER, Christiane Regina
IPC分类号： C07K16/30 , A61K39/395 , A61K45/06 , A61K31/513 , A61K31/519 , A61K31/555 , A61K31/675 , A61K31/704 , A61K31/7068 , A61K33/243 , A61K39/00 , A61P35/00 , C07K16/28
摘要： The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.
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公开(公告)号：EP3254695B1
公开(公告)日：2020-09-09
申请号：EP17171169.0
申请日：2013-05-21
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , MITNACHT-KRAUS, Rita , JACOBS, Stefan, Denis , UTSCH, Magdalena, Jadwiga , HEINZ, Cornelia, Adriana, Maria , STADLER, Christiane, Regina
IPC分类号： A61K39/395 , C07K16/30 , A61K45/06
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公开(公告)号：EP2920209B1
公开(公告)日：2020-08-05
申请号：EP13789492.9
申请日：2013-11-12
申请人： BioNTech SE , Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , STADLER, Christiane , HOLLAND, Julia , BÄHR-MAHMUD, Hayat , BEISSERT, Tim , PLUM, Laura , LE GALL, Fabrice , JENDRETZKI, Arne , FIEDLER, Markus
IPC分类号： C07K16/28
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公开(公告)号：EP2591003B1
公开(公告)日：2020-05-13
申请号：EP11730907.0
申请日：2011-07-04
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , WALTER, Korden , KREUZBERG, Maria , LUXEN, Sylvia
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
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25.发明授权TUMOR VACCINATION INVOLVING A HUMORAL IMMUNE RESPONSE AGAINST SELF-PROTEIN CLDN18.2 有权涉及自身蛋白CLDN18.2的体液免疫应答的肿瘤疫苗
公开(公告)号：EP2547695B1
公开(公告)日：2018-05-09
申请号：EP11707355.1
申请日：2011-03-09
申请人： Biontech Protein Therapeutics GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： KLAMP, Thorsten , SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , HILLER, Thomas , SCHUMACHER, Jens
CPC分类号： C07K14/4748 , A61K39/0011 , A61K2039/5156 , A61K2039/523 , A61K2039/5258 , A61K2039/53 , A61K2039/57 , A61K2039/575 , A61K2039/6075 , C07K14/005 , C07K2319/00 , C07K2319/40 , C12N7/00 , C12N2730/10123 , C12N2730/10134 , C12N2730/10143 , C12N2730/10171
摘要： The present invention relates to tumor immunotherapy, in particular to tumor vaccination, using chimeric proteins comprising all or a portion of a hepatitis B virus core antigen protein and an amino acid sequence comprising an epitope derived from the extracellular portion of a tumor-associated antigen. In particular, the present invention provides virus-like particles comprising said chimeric proteins, which are useful for eliciting a humoral immune response in a subject against the tumor-associated antigen, in particular against cells carrying said tumor-associated antigen on their surface, wherein the tumor-associated antigen is a self-protein in said subject.
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26.发明公开THERAPY INVOLVING ANTIBODIES AGAINST CLAUDIN 18.2 FOR TREATMENT OF CANCER 审中-公开随着对癌症紧密连接蛋白18.2的治疗抗体治疗
公开(公告)号：EP2976360A1
公开(公告)日：2016-01-27
申请号：EP14714586.6
申请日：2014-03-17
申请人： Ganymed Pharmaceuticals AG , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem
IPC分类号： C07K16/28 , C07K16/30 , A61K39/395 , A61P35/00
摘要： The present invention generally provides a therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN 18.2, in particular cancer diseases such as gastroesophageal cancer. Data are presented demonstrating that administration of an anti-CLDN18.2 antibody to human patients with gastroesophageal cancer is safe and well-tolerated up to a dose of at least 1000 mg/m2. Furthermore, data are presented demonstrating that the antibody is fully functional in these patients to execute anti-tumor cell effects and evidence for antitumoral activity was obtained.
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27.发明授权VERWENDUNG VON FLT3-LIGAND ZUR VERSTÄRKUNG VON IMMUNREAKTIONEN BEI RNA-IMMUNISIERUNG 有权FLT3配体对增强免疫反应RNA免疫的使用
公开(公告)号：EP2370101B8
公开(公告)日：2013-05-01
申请号：EP09796949.7
申请日：2009-12-09
申请人： BioNTech AG , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
IPC分类号： A61K39/39 , C07K14/475
CPC分类号： A61K39/39 , A61K2039/53 , A61K2039/55516 , C07K14/475 , C07K2319/00
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公开(公告)号：EP4242236A3
公开(公告)日：2023-11-22
申请号：EP23155995.6
申请日：2008-05-27
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , BRANDENBURG, Gunda , USENER, Dirk
IPC分类号： C07K16/30 , A61K39/395 , A61P35/00 , C12N5/12 , C07K16/28 , A61P35/04 , A61P43/00 , A61P37/04
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, cancer of the gallbladder, and the metastases thereof.
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29.发明公开
公开(公告)号：EP4119582A1
公开(公告)日：2023-01-18
申请号：EP22181929.5
申请日：2013-05-21
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , MITNACHT-KRAUS, Rita , JACOBS, Stefan Denis , UTSCH, Magdalena Jadwiga , HEINZ, Cornelia Adriana Maria , STADLER, Christiane Regina
IPC分类号： C07K16/30 , A61K39/395 , A61K45/06 , A61K31/513 , A61K31/519 , A61K31/555 , A61K31/675 , A61K31/704 , A61K31/7068 , A61K33/243 , A61K39/00 , A61P35/00 , C07K16/28
摘要： The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.
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公开(公告)号：EP3679069A1
公开(公告)日：2020-07-15
申请号：EP18765858.8
申请日：2018-09-05
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
IPC分类号： C07K16/28
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