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公开(公告)号：EP3008055A1
公开(公告)日：2016-04-20
申请号：EP14730804.3
申请日：2014-06-04
发明人： GRETHER, Uwe , NETTEKOVEN, Matthias , PUELLMANN, Bernd , ROEVER, Stephan , ROGERS-EVANS, Mark , SCHULZ-GASCH, Tanja
IPC分类号： C07D403/12 , C07D413/14 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/14 , C07D413/06 , C07D257/04 , C07D491/107 , A61P25/00 , A61K31/41 , A61K31/4439 , A61K31/454
CPC分类号： C07D257/04 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D413/06 , C07D413/14 , C07D491/107
摘要： The invention relates to a compound of formula (I), wherein R
1 and R
2 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.摘要翻译： 本发明涉及式（I）化合物，其中R 1和R 2如说明书和权利要求书中所定义。 式（I）化合物可以用作药物。
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公开(公告)号：EP2928867A1
公开(公告)日：2015-10-14
申请号：EP13799543.7
申请日：2013-12-04
发明人： GRETHER, Uwe , KIMBARA, Atsushi , NETTEKOVEN, Matthias , RICKLIN, Fabienne , ROEVER, Stephan , ROGERS-EVANS, Mark , ROMBACH, Didier , SCHULZ-GASCH, Tanja , WESTPHAL, Matthias
IPC分类号： C07D213/81 , C07D413/14 , C07D401/06 , C07D401/12 , C07D405/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D491/10 , A61K31/444 , A61P29/00
CPC分类号： C07D213/81 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/10 , C07D491/107
摘要： The invention relates to a compound of formula (I) wherein R
1 to R
4 are defined as in the description and in the claims. The compound of formula (I) is a CB2 agonist and can be used as an active ingredient in a medicament.摘要翻译： 本发明涉及式（I）化合物，其中R 1至R 4如在说明书和权利要求书中所定义。 式（I）化合物是CB 2激动剂，可用作药物中的活性成分。
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公开(公告)号：EP2870139A1
公开(公告)日：2015-05-13
申请号：EP13732543.7
申请日：2013-07-01
发明人： KIMBARA, Atsushi , GRETHER, Uwe , NETTEKOVEN, Matthias , PUELLMANN, Bernd , ROGERS-EVANS, Mark , SCHULZ-GASCH, Tanja
IPC分类号： C07D215/08 , C07D215/14 , C07D215/233 , C07D215/50 , C07D215/54 , C07D217/06 , C07D241/42 , C07D271/04 , C07D265/36 , C07D209/08 , C07D209/44 , A61K31/47 , A61K31/403 , A61P29/00
CPC分类号： C07D471/04 , C07D209/08 , C07D209/44 , C07D215/08 , C07D215/14 , C07D215/233 , C07D215/50 , C07D215/54 , C07D217/04 , C07D217/06 , C07D241/42 , C07D265/36
摘要： The invention relates to a compound of formula (I), wherein i.a. A
1 is -CH2- or -C(O)-; one of R
1 and R
2 is hydrogen and the other one is -A
2 -C(O)-R
3 ; A
2 is NH- or absent; and R
3 is (A), (B) or (C) The compounds are preferential agonists of the cannabinoid receptor 2 (CB2) and can be used as medicaments for the treatment of pain, inflammation, ischemia, etc.-
公开(公告)号：EP2509966B1
公开(公告)日：2014-10-22
申请号：EP10790920.2
申请日：2010-12-07
IPC分类号： C07D265/08 , C07D413/12 , C07D417/12 , C07D495/04 , C07D498/04 , A61K31/5355 , A61P3/10
CPC分类号： C07D413/12 , C07D265/08 , C07D417/12 , C07D495/04 , C07D498/04
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25.发明公开[1, 2, 3]TRIAZOLO [4, 5 -D]PYRIMIDINE DERIVATIVES AS AGONISTS OF THE CANNABINOID RECEPTOR 2 AGONISTS 有权[1,2,3]三唑并[4,5-d]嘧啶衍生物作为大麻素受体2激动剂的激动剂
公开(公告)号：EP2782915A1
公开(公告)日：2014-10-01
申请号：EP12794684.6
申请日：2012-11-22
发明人： BISSANTZ, Caterina , GRETHER, Uwe , KIMBARA, Atsushi , NETTEKOVEN, Matthias , ROEVER, Stephan , ROGERS-EVANS, Mark
IPC分类号： C07D487/04 , A61K31/519
CPC分类号： C07D487/04 , A61K9/0019 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/4858 , A61K47/10 , A61K47/12
摘要： The invention relates to a compound of formula (I) wherein A and R to R 3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
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26.发明公开[1, 2, 3]TRIAZOLO [4, 5 -D]PYRIMIDINE DERIVATIVES AS AGONISTS OF THE CANNABINOID RECEPTOR 2 有权[1,2,3]三唑并[4,5-D]嘧啶衍生物作为大麻素受体2激动剂
公开(公告)号：EP2776442A1
公开(公告)日：2014-09-17
申请号：EP12780208.0
申请日：2012-11-05
发明人： ADAM, Jean-Michel , BISSANTZ, Caterina , GRETHER, Uwe , KIMBARA, Atushi , NETTEKOVEN, Matthias , ROEVER, Stephan , ROGERS-EVANS, Mark
IPC分类号： C07D487/04 , A61K31/519 , A61P3/10 , A61P9/10 , A61P27/06
CPC分类号： C07D487/04 , A61K9/0019 , A61K9/2054 , A61K9/4866 , A61K31/519 , A61K47/10 , C07D491/107
摘要： The invention relates to a compound of formula (I), wherein A, R
1 and R
2 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament as agonists of the cannabinoid receptor 2.-
公开(公告)号：EP2771327A1
公开(公告)日：2014-09-03
申请号：EP12778342.1
申请日：2012-10-25
发明人： BISSANTZ, Caterina , DHURWASULU, Baledi , GRETHER, Uwe , HAZRA, Anindya , HEBEISEN, Paul , ROEVER, Stephan , ROGERS-EVANS, Mark
IPC分类号： C07D241/12 , C07D241/18 , C07D401/12 , C07D403/04 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , A61K31/497 , A61P9/00
CPC分类号： C07D413/12 , C07D241/12 , C07D241/18 , C07D401/12 , C07D403/04 , C07D405/12 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The invention relates to a compound of formula (I), wherein R
1 to R
4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.-
28.发明授权2,5,6,7-TETRAHYDRO-[1,4]OXAZEPIN-3-YLAMINE OR 2,3,6,7-TETRAHYDRO-[1,4]OXAZEPIN-5-YLAMINE COMPOUNDS 有权2,5,6,7-四氢 - [1,4]氧杂环己烯-3-基亚胺ODER 2,3,6,7-四氢 - [1,4]氧杂环己烯-5-木兰VERBINDUNGEN
公开(公告)号：EP2566855B1
公开(公告)日：2014-05-21
申请号：EP11720065.9
申请日：2011-05-03
发明人： BANNER, David , GUBA, Wolfgang , HILPERT, Hans , HUMM, Roland , MAUSER, Harald , MAYWEG, Alexander, V. , NARQUIZIAN, Robert , POWER, Eoin , ROGERS-EVANS, Mark , ROMBACH, Didier , WOLTERING, Thomas , WOSTL, Wolfgang
IPC分类号： C07D267/10 , C07D413/12 , C07D417/12 , A61K31/553 , A61P25/28
CPC分类号： C07D267/10 , C07D413/12 , C07D417/12
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公开(公告)号：EP2089381B1
公开(公告)日：2010-06-30
申请号：EP07847501.9
申请日：2007-11-29
发明人： BISSANTZ, Caterina , GRUNDSCHOBER, Christophe , MASCIADRI, Raffaello , RATNI, Hasane , ROGERS-EVANS, Mark , SCHNIDER, Patrick
IPC分类号： C07D401/14 , C07D491/04 , A61K31/4427 , A61P25/22 , A61P25/24
CPC分类号： C07D401/14 , C07D491/04
摘要： The present invention is concerned with novel indol-2-yl-carbonyl-piperidin- benzoimidazolon and indol-2-yl-carbonyl-piperidin-benzoxazolon derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful in the prevention and/or treatment of anxiety and depressive disorders and other diseases. Present invention comprises compounds of the general formula (I) wherein R1 to R11, X and Y are as defined in the specification.
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公开(公告)号：EP2102207B1
公开(公告)日：2010-06-02
申请号：EP07847502.7
申请日：2007-11-29
发明人： BISSANTZ, Caterina , GRUNDSCHOBER, Christophe , MASCIADRI, Raffaello , RATNI, Hasane , ROGERS-EVANS, Mark , SCHNIDER, Patrick
IPC分类号： C07D471/10 , C07D491/10 , C07D519/00 , A61P9/00
CPC分类号： C07D471/10 , C07D491/10 , C07D519/00
摘要： The present invention is concerned with novel indol-2-yl-carbonyl-spiro-piperidine derivatives as VIa receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful in the prevention and/or treatment of anxiety and depressive disorders and other diseases. The compounds of present invention are represented by the general formula (I) wherein R1 to R1, X and Y are as defined in the specification.
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