利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

37 条记录 (耗时 0.023 秒)

    New cephem compounds and processes for preparation thereof
    22.
    发明公开
    New cephem compounds and processes for preparation thereof 失效
    Cephalosporinderivate和Verfahren zu ihrer Herstellung。

    公开(公告)号：EP0071891A2

    公开(公告)日：1983-02-16

    申请号：EP82106857.4

    申请日：1982-07-29

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： Takaya, Takao ,  Takasugi, Hisashi ,  Yamanaka, Hideaki

    IPC分类号： C07D501/20 ,  C07D501/59 ,  C07D501/00 ,  C07D277/20 ,  A61K31/545

    CPC分类号： C07D277/587

    摘要： A compound of the formula:
    wherein

    R' is carboxy(lower)alkyl or protected carboxy(lower)-alkyl,
    R 2 is carboxy or protected carboxy,
    R 3 is hydrogen or lower alkyl, and
    R 4 is lower alkyl, lower alkoxy, acyloxymethyl, lower alkylthiomethyl, lower alkoxymethyl, halogen, lower alkenyl or hydrogen,

    and pharmaceutically acceptable salts thereof, and processes for the preparation thereof and also an antibacterial composition comprising the above compound in association with pharmaceutically acceptable carriers. The invention further relates to intermediate compounds of the formula
    and the preparation thereof.

    摘要翻译： 其中R 1为羧基（低级）烷基或保护的羧基（低级）烷基，R 2为羧基或被保护的羧基，R 3为氢或 低级烷基和... R 4是低级烷基，低级烷氧基，酰氧基甲基，低级烷硫基甲基，低级烷氧基甲基，卤素，低级烯基或氢，及其药学上可接受的盐，以及其制备方法以及抗菌组合物， 上述化合物与药学上可接受的载体结合。 本发明还涉及下式的中间体化合物及其制备方法。

    New cephem compounds, processes for preparation thereof and pharmaceutical composition containing them
    23.
    发明公开
    New cephem compounds, processes for preparation thereof and pharmaceutical composition containing them 失效
    头孢菌素化合物，它们的制备方法和含有它们的药物组合物。

    公开(公告)号：EP0057422A2

    公开(公告)日：1982-08-11

    申请号：EP82100564.2

    申请日：1982-01-28

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： Takaya, Takao ,  Takasugi, Hisashi ,  Yamanaka, Hideaki

    IPC分类号： C07D501/59 ,  A61K31/545 ,  C07D285/10 ,  C07C131/00

    CPC分类号： C07D277/587 ,  C07D277/30 ,  C07D285/10

    摘要： A cephem compound of the formula:
    wherein

    R ' is amino substituted thiazolyl which may have halogen(s),

    protected amino substituted thiazolyl which may have halogen(s),
    lower alkylamino substituted thiazolyl, amino substituted thiadiazolyl,
    protected amino-substituted thiadiazolyl, amino substituted pyridyl,
    protected amino substituted pyridyl, furyl, thiazolyl, thiadiazolyl, phenyl, or naphthyl,

    R 2 is carboxy(lower)alkyl or protected carboxy(lower)-alkyl,
    R 3 is lower alkylthio, and
    R 4 is carboxy or protected carboxy,

    and pharmaceutically acceptable salts thereof, and processes for their preparation, and also a pharmaceutical composition comprising, as an active ingredient, the above compound or its pharmaceutically acceptable salt.
    The invention also relates to intermediate compounds.

    摘要翻译： 下式的头孢菌烷化合物：... ... worin ...... [R <1>是氨基噻唑substituiertem可具有卤素（S）...保护的氨基噻唑基substituiertem可具有卤素（S）...低级烷基氨基substituiertem噻唑基，氨基 substituiertem噻二唑基，...保护的氨基 - 噻二唑基substituiertem，氨基吡啶基substituiertem ...保护的氨基substituiertem吡啶基，呋喃基，噻唑基，噻二唑基，苯基，或萘基，...... [R <2>是羧基（低级）烷基或保护的羧基（低级）烷基， ... [R <3>是低级烷硫基，和...... [R <4>是羧基或保护的羧基，...和药学上可接受的盐，以及它们的制备方法，因此，其包含一种药物组合物作为活性成分的，上述化合物或 其药学上可接受的盐。 ... 本发明因此涉及到的中间体化合物。

    Cephem compounds and processes for preparation thereof
    26.
    发明公开
    Cephem compounds and processes for preparation thereof 失效
    头孢烯化合物及其制备方法

    公开(公告)号：EP0345671A2

    公开(公告)日：1989-12-13

    申请号：EP89110068.7

    申请日：1989-06-03

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： Yamanaka, Hideaki ,  Yoshida, Yoshiki ,  Goto, Jiro ,  Terasawa, Takeshi ,  Okuda, Shinya ,  Sakane, Kazuo

    IPC分类号： C07D501/46 ,  A61K31/545 ,  C07D501/18

    CPC分类号： C07D501/46

    摘要： A compound of the formula :
    wherein

    R' is amino or a protected amino group,
    Z is N or CH,
    R 2 is an organic group, and
    R is a group of the formula :

    (in which
    R 3 and R 4 are each lower alkyl, or
    R 3 and R 4 are linked together to form C 3 -C 6 alkylene,
    A is lower alkylene, and
    R 5 is hydroxy or a protected hydroxy group)
    or a group of the formula :
    (in which
    R 6 is lower alkyl.
    R 7 and R 8 are each hydroxy or a protected hydroxy group, and
    Y is N or CH),
    and a pharmaceutically acceptable salt thereof,
    processes for their preparation and pharmaceutical compositions comprising them as an active ingredient. The invention relates also to intermediates of the formula
    and their preparation.

    摘要翻译： 下式化合物：其中R'为氨基或被保护的氨基，Z为N或CH，R2为有机基团，R为下式基团（其中R3和R4各为低级烷基，或 R 3和R 4连接在一起形成C 3 -C 6亚烷基，A是低级亚烷基，并且R 5是羟基或被保护的羟基）或下式的基团（其中R 6是低级烷基，R 7和R 8各自是羟基或 被保护的羟基，并且Y是N或CH）及其药学上可接受的盐，它们的制备方法和包含它们作为活性成分的药物组合物。 本发明还涉及式的中间体及其制备。