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46 条记录 (耗时 0.026 秒)

    New cephem compounds and processes for preparation thereof
    1.
    发明公开
    New cephem compounds and processes for preparation thereof 失效
    Cephemderivate和Verfahren zu ihrer Herstellung。

    公开(公告)号：EP0427248A2

    公开(公告)日：1991-05-15

    申请号：EP90121341.3

    申请日：1990-11-08

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： Sakane, Kazuo ,  Kawabata, Kohji ,  Inamoto, Yoshiko

    IPC分类号： C07D501/46 ,  A61K31/545 ,  C07D501/18

    CPC分类号： C07D501/00 ,  Y02P20/55

    摘要： A compound of the formula


    wherein R 1 is amino or a protected amino group,
    R 2 is hydrogen or an organic group,
    R 3 is hydrogen, lower alkyl,
    hydrory(lower)alkyl, protected hydroxy(lower)alkyl, amino(lower)alkyl, protected amino(lower)alkyl, carbamoyl-(lower)alkyl, N,N-di(lower)alkylcarbamoyl(lower)alkyl or an imino protective group,
    R 4 is hydrogen, lower alkyl, carboxy, protected carboxy, amino,protected amino or carbamoyl, and
    Z is N or CH,
    and a pharmaceutically acceptable salt thereof,
    processes for their preparation and pharmaceutical compositions comprising them as an active ingredient in admixture with pharmaceutically acceptable carriers. The invention also relates to intermediates of the formula
    and processes for their preparation.

    摘要翻译： 式CHEM的化合物，其中R 1为氨基或被保护的氨基，R 2为氢或有机基团，R 3为氢，低级烷基，低级（低级）烷基，被保护的羟基 （低级）烷基，被保护的氨基（低级）烷基，氨基甲酰基（低级）烷基，N，N-二（低级）烷基氨基甲酰基（低级）烷基或亚氨基保护基，R 4是氢， 低级烷基，羧基，被保护的羧基，氨基，保护的氨基或氨基甲酰基，Z是N或CH及其药学上可接受的盐，其制备方法和药物组合物包含它们作为活性成分与药学上可接受的载体的混合物。 本发明还涉及式CHEM的中间体及其制备方法。 ñ

    New cephem compounds and processes for preparation thereof
    2.
    发明公开
    New cephem compounds and processes for preparation thereof 失效
    Cephemverbindungen und Verfahren zu ihrer Herstellung。

    公开(公告)号：EP0223246A2

    公开(公告)日：1987-05-27

    申请号：EP86116032.3

    申请日：1986-11-19

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： Takaya, Takao ,  Sakane, Kazuo ,  Miyai, Kenzi ,  Kawabata, Kohji

    IPC分类号： C07D501/46 ,  A61K31/545

    CPC分类号： C07D501/46 ,  Y02P20/55

    摘要： A new cephem compound of the formula:
    wherein

    R' is amino or protected amino,
    R 2 is hydrogen, hydroxy protective group, lower alkyl, dihalogenated lower alkyl, cyclo(lower)alkenyl, thietanyl, carboxy(lower)alkyl or protected carboxy(lower)alkyl,
    R 3 is lower alkyl,
    R 4 and R 5 are each hydrogen, lower alkyl, hydroxy (lower)alkyl, lower alkoxy, amino or protected amino,
    R 6 is COO e , carboxy or protected carboxy,
    X ⊖ is an anion, and
    n is 0 or 1, with certain provisions, processes for their preparation and pharmaceutical compositions containing them. The invention relates also to compounds of the formula
    and of the formula
    in which Z is an acid residue.

    摘要翻译： 一种新的头孢烯化合物，其化学式为：... 其中... R 1为氨基或被保护的氨基，R 2为氢，羟基保护基，低级烷基，二卤代低级烷基，环（低级）烯基 （低级）烷基或被保护的羧基（低级）烷基，R 3是低级烷基，R 4和R 5分别是氢，低级烷基，羟基（低级）烷基，低级烷氧基 ，氨基或被保护的氨基，R 6是COO（ - ） - ，羧基或受保护的羧基，X（ - ））是阴离子，并且... n是0或1，具有一些规定，其制备方法 和含有它们的药物组合物。 本发明还涉及其中Z是酸残基的式... ... CH 2 CH 2 ...的化合物和式... CHEM> ...的化合物。

    Cephem compounds and processes for preparation thereof
    3.
    发明公开
    Cephem compounds and processes for preparation thereof 失效
    Cephalosporinverbindungen和Verfahren zu ihrer Herstellung。

    公开(公告)号：EP0145906A2

    公开(公告)日：1985-06-26

    申请号：EP84112968.7

    申请日：1984-10-27

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： Takaya, Takao ,  Tozuka, Zenzaburo ,  Yasuda, Nobuyoshi ,  Kawabata, Kohji

    IPC分类号： C07D501/24 ,  A61K31/545

    CPC分类号： C07D213/32 ,  C07C321/00

    摘要： New cephem compounds of the formula:
    wherein

    R' is amino or protected amino,
    R' is aryl which may have suitable substituent(s), a heterocyclic group which may have suitable substituent(s), cyano, hydrogen or tri(lower)alkylsilyl,
    R' is carboxy or protected carboxy, and
    A is -CH=CH- or -C≡C-, and pharmaceutically acceptable saltthereof, processes for their preparation and pharmaceutical compositions containing them in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient. The invention also relates to intermediates of the formula
    and processes for their preparation.

    摘要翻译： 新的头孢烯化合物，其化学式为：... 其中R 1为氨基或被保护的氨基，R 2为可具有合适取代基的芳基，可具有适当取代基的杂环基 ），氰基，氢或三（低级）烷基甲硅烷基，... R 3是羧基或被保护的羧基，A是-CH = CH-或-C定义的C-及其药学上可接受的盐，其制备方法 以及含有药学上可接受的，基本上无毒的载体或赋形剂的药物组合物。 本发明还涉及式...的中间体...及其制备方法。

    New cephem compounds and processes for preparation thereof
    4.
    发明公开
    New cephem compounds and processes for preparation thereof 失效
    Cephemverbindungen und Verfahren zu ihrer Herstellung。

    公开(公告)号：EP0109683A2

    公开(公告)日：1984-05-30

    申请号：EP83111583.7

    申请日：1983-11-19

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： Takaya, Takao ,  Masugi, Takashi ,  Kawabata, Kohji

    IPC分类号： C07D501/22 ,  C07D501/24 ,  A61K31/545

    CPC分类号： C07D501/22 ,  C07D501/24

    摘要： New cephem compounds of the formula:
    wherein

    R 1 is amino or acylamino,
    R 2 is 2,2-dihalovinyl or ethynyl, and
    R 3 is carboxy or protected carboxy,

    and pharmaceutically acceptable salts thereof, processes for their preparations and pharmaceutical compositions comprising an effective amount of them or pharmaceutical acceptable salt thereof in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient. The invention also relates to the 1-oxides of such compounds and salts thereof.

    摘要翻译： 新的头孢烯化合物，其结构如下：... 其中R 1为氨基或酰氨基，R 2为2,2-二卤乙烯基或乙炔基，R 3为羧基或被保护的羧基， 其药学上可接受的盐，其制备方法和包含其有效量的药物组合物或其药学上可接受的盐与药学上可接受的，基本上无毒的载体或赋形剂相结合。 本发明还涉及这些化合物的1-氧化物及其盐。

    New Cephem Compounds
    8.
    发明公开
    New Cephem Compounds 失效
    Cephemverbindungen。

    公开(公告)号：EP0517041A1

    公开(公告)日：1992-12-09

    申请号：EP92108580.9

    申请日：1992-05-21

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： Kawabata, Kohji ,  Okuda, Shinya ,  Yoshida, Yoshiki ,  Eikyu, Yoshiteru ,  Ogawa, Yasuhiro ,  Yamanaka, Hideaki ,  Sakane, Kazuo

    IPC分类号： C07D501/46 ,  C07D285/08 ,  A61K31/545

    CPC分类号： C07D501/00 ,  Y02P20/55

    摘要： A compound of the formula :

    wherein

    R¹ is amino or protected amino,
    R² is lower alkyl substituted with 1 to 6 halogen,
    R³ is hydroxy(lower)alkyl, protected hydroxy(lower)alkyl or halo(lower)alkyl and
    R⁴ is hydrogen, or
    R³ and R⁴ are linked together to form lower alkylene, and
    R⁵ is hydrogen or an amino protective group,
    and a pharmaceutically acceptable salt thereof, processes for their preparation and pharmaceutical compositions comprising them. The invention also relates to intermediate products of the formula

    and processes for their preparation.

    摘要翻译： 下式的化合物：其中R 1为氨基或被保护的氨基，R 2为被1至6个卤素取代的低级烷基，R 3为羟基（低级）烷基，被保护的羟基（低级） 烷基或卤代（低级）烷基，R 4是氢，或R 3和R 4连接在一起形成低级亚烷基，R 5是氢或氨基保护基，和药学上可接受的 其盐，其制备方法和包含它们的药物组合物。 本发明还涉及式CHEM的中间产物及其制备方法。 Ë

    Cephem compounds and processes for preparation thereof
    9.
    发明公开
    Cephem compounds and processes for preparation thereof 失效
    新CEPHEM化合物及其制备方法

    公开(公告)号：EP0332156A3

    公开(公告)日：1991-10-16

    申请号：EP89104048.7

    申请日：1989-03-08

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： Sakane, Kazuo ,  Kawabata, Kohji ,  Inamoto, Yoshiko

    IPC分类号： C07D501/46 ,  C07D501/18 ,  A61K31/545

    CPC分类号： C07D519/00 ,  Y02P20/55

    摘要： A compound of the formula :
    wherein R 1 is amino or a protected amino group,
    R 2 is an organic group, R 3 is hydrogen, lower alkyl, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, amino(lower)alkyl, protected amino(lower)alkyl or an imino protective group, R 4 is hydrogen, lower alkyl or lower alkylthio, A is lower alkylene which may be substituted with suitable substituent(s) and Z is N or CH,
    and a pharmaceutically acceptable salt thereof, processes for its preparation and pharmaceutical compositions comprising them or a pharmaceutically acceptable salt thereof in admixture with pharmaceutically acceptable carriers.