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    Method for producing a hydroxyalkyl starch derivatives with two linkers
    22.
    发明公开
    Method for producing a hydroxyalkyl starch derivatives with two linkers 审中-公开
    Verfahren zur Herstellung einesHydroxkylstärkederivatsmit zwei Linkern

    公开(公告)号：EP2070951A1

    公开(公告)日：2009-06-17

    申请号：EP07024351.4

    申请日：2007-12-14

    申请人： Fresenius Kabi Deutschland GmbH

    发明人： Hacket, Frank ,  Eichner, Wolfram ,  Knoller, Helmut ,  Mitsch, Andreas ,  Schimmel, Martin ,  Zander, Norbert

    IPC分类号： C08B31/12 ,  A61K47/48

    CPC分类号： C08B31/12 ,  A61K47/61

    摘要： A method of producing a hydroxyalkyl starch (HAS) derivative, comprising
    a) reacting optionally oxidized hydroxyalkyl starch with a compound (D) comprising at least two functional groups -O-NH 2 or a salt thereof, and
    b) reacting the hydroxyalkyl starch derivative obtained in step a) with a compound (L) comprising at least two functional groups W 1 and W 2 independently selected from the group consisting of an aldehyde group, a suitably protected aldehyde group, a keto group, and a suitably protected keto group.

    摘要翻译： 一种制备羟烷基淀粉（HAS）衍生物的方法，包括：a）任选地氧化的羟烷基淀粉与包含至少两个官能团-O-NH 2或其盐的化合物（D）反应，和b）使羟烷基淀粉衍生物 在步骤a）中获得的化合物（L）与包含至少两个官能团W 1和W 2的化合物（L）独立地选自醛基，适当保护的醛基，酮基和适当保护的酮基。