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21.发明公开Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开Sekretierte Transmembranproteine unddafürkodierendeNukleinsäuren
公开(公告)号：EP1688497A1
公开(公告)日：2006-08-09
申请号：EP06000586.5
申请日：2000-12-01
申请人： GENENTECH, INC.
发明人： Baker, Kevin P. , Beresini, Maureen , Deforge, Laura , Desnoyers, Luc , Filvaroff, Ellen , Gao, Wei-Qiang , Gerritsen, Mary E. , Goddard, Audrey , Godowski, Paul J. , Gurney, Austin L. , Sherwood, Steven , Smith, Victoria , Stewart, Timothy A. , Tumas, Daniel , Wantanbe, Colin K. , Wood, William I.
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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22.发明公开Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开Ausgeschiedene和Transmembran-Polypeptide unddafürkodierendeNukleinsäuren
公开(公告)号：EP1686134A2
公开(公告)日：2006-08-02
申请号：EP06000583.2
申请日：2000-12-01
申请人： GENENTECH, INC.
发明人： Baker, Kevin P. , Beresini, Maureen , Deforge, Laura , Desnoyers, Luc , Filvaroff, Ellen , Gao, Wei-Qiang , Gerritsen, Mary E. , Goddard, Audrey , Godowski, Paul J. , Gurney, Austin L. , Sherwood, Steven , Smith, Victoria , Stewart, Timothy A. , Tumas, Daniel , Wantanbe, Colin K. , Wood, William I.
IPC分类号： C07K14/47
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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23.发明公开Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开Ausgeschiedene和Transmembranpolypeptide和dafürkodierendeNukleinsäuren
公开(公告)号：EP1683864A2
公开(公告)日：2006-07-26
申请号：EP05024023.3
申请日：2001-06-01
申请人： GENENTECH, INC.
发明人： Baker, Kevin P. , Desnoyers, Luc , Gerritsen, Mary E. , Goddard, Audrey , Godowski, Paul J. , Grimaldi, Christopher J. , Gurney, Austin L. , Smith, Victoria , Stephan, Jean-Philippe F. , Watanabe, Colin K. , Wood, William I.
CPC分类号： C07K14/705 , C07K14/47 , C07K2319/20 , C07K2319/30 , G01N33/574
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明
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公开(公告)号：EP1669371A3
公开(公告)日：2006-06-21
申请号：EP06000584.0
申请日：2000-12-01
申请人： GENENTECH, INC.
发明人： Baker, Kevin P. , Beresini, Maureen , Deforge, Laura , Desnoyers, Luc , Filvaroff, Ellen , Gao, Wei-Qiang , Gerritsen, Mary E. , Goddard, Audrey , Godowski, Paul J. , Gurney, Austin L. , Sherwood, Steven , Smith, Victoria , Stewart, Timothy A. , Tumas, Daniel , Wantanbe, Colin K. , Wood, William I.
IPC分类号： C07K14/47 , G01N33/574 , C07K16/18 , C12Q1/68
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新的多肽和编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，结合本发明多肽的抗体以及产生本发明多肽的方法 发明。
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25.发明公开Polypeptide, nucleic acid encoding it, and their use for the diagnosis of cancer 审中-公开多肽，核酸编码，以及它们在诊断癌症使用
公开(公告)号：EP1666497A3
公开(公告)日：2006-06-21
申请号：EP05024034.0
申请日：2001-06-01
申请人： GENENTECH, INC.
发明人： Baker, Kevin P. , Desnoyers, Luc , Gerritsen, Mary E. , Goddard, Audrey , Godowski, Paul J. , Grimaldi, Christopher J. , Gurney, Austin L. , Smith, Victoria , Stephan, Jean-Philippe F. , Watanabe, Colin K. , Wood, William I.
IPC分类号： C07K14/705 , C12Q1/68 , G01N33/574 , C12N15/12 , C12N15/62 , C07K16/28
CPC分类号： G01N33/57407 , C07K14/47 , G01N33/57492
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：EP1661997A1
公开(公告)日：2006-05-31
申请号：EP06000589.9
申请日：2000-12-01
申请人： GENENTECH, INC.
发明人： Baker, Kevin P. , Beresini, Maureen , Deforge, Laura , Desnoyers, Luc , Filvaroff, Ellen , Gao, Wei-Qiang , Gerritsen, Mary E. , Goddard, Audrey , Godowski, Paul J. , Gurney, Austin L. , Sherwood, Steven , Smith, Victoria , Stewart, Timothy A. , Tumas, Daniel , Wantanbe, Colin K. , Wood, William I.
IPC分类号： C12N15/12 , C07K14/47 , C07K14/705 , C12N15/62 , C07K16/18 , C07K16/28 , G01N33/53 , A61K38/17 , C12Q1/68
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：EP1659177A2
公开(公告)日：2006-05-24
申请号：EP05024032.4
申请日：2001-06-01
申请人： GENENTECH, INC.
发明人： Baker, Kevin P. , Desnoyers, Luc , Gerritsen, Mary E. , Goddard, Audrey , Godowski, Paul J. , Grimaldi, Christopher J. , Gurney, Austin L. , Smith, Victoria , Stephan, Jean-Philippe F. , Watanabe, Colin K. , Wood, William I.
IPC分类号： C12N15/12 , C07K14/47 , C07K16/18 , C12Q1/68 , G01N33/574
CPC分类号： G01N33/57407 , C07K14/47 , G01N33/57492
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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28.发明公开Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开Sekretierte和跨膜Polypeptide unddafürkodierendeNukleinsäuren
公开(公告)号：EP1657251A2
公开(公告)日：2006-05-17
申请号：EP05024036.5
申请日：2001-06-01
申请人： GENENTECH, INC.
发明人： Baker, Kevin P. , Desnoyers, Luc , Gerritsen, Mary E. , Goddard, Audrey , Godowski, Paul J. , Grimaldi, Christopher J. , Gurney, Austin L. , Smith, Victoria , Stephan, Jean-Philippe F. , Watanabe, Colin K. , Wood, William I.
CPC分类号： G01N33/57492 , C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：EP1632499A3
公开(公告)日：2006-03-15
申请号：EP05018354.0
申请日：2000-02-11
申请人： GENENTECH, INC.
发明人： Ashkenazi, Avi J. , Goddard, Audrey , Godowski, Paul J. , Gurney, Austin L. , Hillan, Kenneth J. , Masters, Scot A. , Pan, James , Pitti, Robert M. , Roy, Margaret Ann , Smith, Victoria , Stone, Donna M. , Watanabe, Colin K. , Wood, William I.
IPC分类号： C07K14/705 , C12Q1/68 , G01N33/574
CPC分类号： G01N33/57484 , A61K31/7088 , A61K39/395 , A61K45/00 , A61K45/06 , A61K48/00 , C07K14/47 , C07K14/705 , C07K14/72 , C07K14/82 , C07K16/18 , C07K16/30 , C07K16/32 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/62 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12Q1/6886 , C12Q2600/136 , G01N33/15 , G01N33/50 , G01N33/574 , G01N33/57496
摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as predictors of the prognosis of tumor treatment.
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.摘要翻译： 本发明涉及用于诊断和治疗哺乳动物（包括人）中的肿瘤细胞生长和增殖的组合物和方法。 本发明基于鉴定在肿瘤细胞基因组中扩增的基因。 与相同组织类型的正常细胞相比，预计这种基因扩增与基因产物的过度表达相关并且有助于肿瘤发生。 因此，由扩增基因编码的蛋白质被认为是用于某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且可以充当肿瘤治疗预后的预测因子。 本发明涉及新的多肽和编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，结合本发明多肽的抗体以及产生本发明多肽的方法 发明。
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公开(公告)号：EP1445317A3
公开(公告)日：2004-12-15
申请号：EP04011151.0
申请日：2001-06-22
申请人： Genentech Inc.
发明人： Goddard, Audrey , Godowski, Paul J. , Gurney, Austin L. , Hillan, Kenneth J. , Polakis, Paul , Smith, Victoria , Wood, William I. , Wu, Thomas D. , Zhang, Zemin
IPC分类号： C12N15/12 , C12Q1/68 , G01N33/574 , C07K16/18 , A61K39/395 , A61K31/7088
CPC分类号： A61K31/7088 , A61K39/395 , C07K16/18 , C12Q1/68 , G01N33/574
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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