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31 条记录 (耗时 0.013 秒)

    Mitomycin analogues
    22.
    发明公开
    Mitomycin analogues 失效
    丝裂霉素类比。

    公开(公告)号：EP0116208A1

    公开(公告)日：1984-08-22

    申请号：EP83307423.0

    申请日：1983-12-06

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： Kono, Motomichi ,  Saito, Yutaka ,  Goto, Jyoji ,  Shirahata, Kunikatsu ,  Morimoto, Makoto ,  Ashizawa, Tadashi

    IPC分类号： C07D487/14 ,  A61K31/40 ,  A61K31/44

    CPC分类号： C07D487/14

    摘要： Compounds of the general formula:
    {wherein X represents a
    group [in which R 3 represents a cycloalkyl or straight chain or branched alkyl group having up to 7 carbon atoms, said alkyl or cycloalkyl group optionally carrying 1 to 3 amino groups and/or 1 to 3 hydroxyl groups; a -(CH 2 ) n CO 2 R 4 group (in which n is the integer 1, 2 or 3, and R 4 represents a methyl or ethyl group); a pyridyl group; or a group of the formula:
    and R, and R 2 which may be the same or different, each represents a hydrogen atom or a methyl group, and indicates a or β bonding] possess good antibacterial and anti-tumor activity.
    The compounds of formula I may be prepared for example by reaction of mitomycin A, B, F or J with the appropriate amine.

    摘要翻译： 通式的化合物：其中X表示基[其中R 3表示具有至多7个碳原子的环烷基或直链或支链烷基，所述烷基或环烷基任选地含有1-3个氨基 基团和/或1至3个羟基; （CH 2）n CO 2 R 4基团（其中n为整数1,2或3，R 4表示甲基或乙基）; 吡啶基; 或下式的基团：可以相同或不同的R 1和R 2各自表示氢原子或甲基，表示α或β键]具有良好的抗菌和抗肿瘤活性。 式I化合物可以例如通过丝裂霉素A，B，F或J与适当的胺反应来制备。

    7-n,8-n-ethylenemitomycin 8-imines, pharmaceutical compositions and use
    24.
    发明公开
    7-n,8-n-ethylenemitomycin 8-imines, pharmaceutical compositions and use 失效
    7-N，8-N-乙酰基丝氨酸8-IMINES，药物组合物和用途

    公开(公告)号：EP0287855A3

    公开(公告)日：1990-04-25

    申请号：EP88105055.3

    申请日：1988-03-29

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： Saito, Yutaka ,  Kasai, Masaji ,  Shirahata, Kunikatsu ,  Kono, Motomichi ,  Morimoto, Makoto ,  Ashizawa, Tadashi

    IPC分类号： C07D487/22 ,  A61K31/495

    CPC分类号： C07D487/22

    摘要： 7-N,8-N-ethylenemitomycin 8-imines represented by the formula
    wherein one of R₁ and R₂ represents carbamoyloxymethyl and another represents hydrogen or both are combined together to form methylene; R₃, R₄, R₅ and R₆ each independently represent hydrogen or C₁₋₄ alkyl, or R₃ and R₄ may be combined together to represent -(CH₂) n -, wherein n is 3 or 4; and Y and Z represent hydrogen or methyl, provided that when R₁ represents carbamoyloxymethyl and Y represents methyl, R₂, R₃, R₄, R₅, R₆ and Z are not hydrogen simultaneously, has an excellent antitumor activity.

    摘要翻译： 由式表示的7-N，8-N-亚乙基霉素8-亚胺，其中R 1和R 2之一表示氨基甲酰氧基甲基，另一个表示氢或两者结合在一起形成亚甲基; R 3，R 4，R 5和R 6各自独立地表示氢或C 1-4烷基，或者R 3和R 4可以组合在一起表示 - （CH 2）n - ，其中n为3或4; 并且Y和Z表示氢或甲基，条件是当R 1表示氨基甲酰氧基甲基且Y表示甲基时，R 2，R 3，R 4，R 5，R 6和Z不同时为氢，具有优异的抗肿瘤活性。

    Fish growth hormone
    28.
    发明公开
    Fish growth hormone 失效
    鱼生长激素

    公开(公告)号：EP0157423A3

    公开(公告)日：1987-04-22

    申请号：EP85104089

    申请日：1985-04-04

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： Kawauchi, Hiroshi ,  Yamaguchi, Kazuo ,  Shirahata, Kunikatsu

    IPC分类号： C07K07/00 ,  A61K37/24

    CPC分类号： C07K14/461 ,  A61K38/00 ,  Y10S930/12

    摘要： A fish growth hormone provided by a purified extract obtained from the pituitary gland of a fish belonging to salmonoid; the hormone is a polypeptide having the following physicochemical properties:
    (I) amino acid composition: as indicated in table 1; (II) the sequences of 33 amino acids at the N-terminal and 23 amino acids at the C-terminal are as follows:
    N-terminal: H 2 N-Ile-Glu-Asn-Gln-Arg-Leu-Phe-Asn-Ile-Ala-Val-Ser-Arg-Val-Gln-His-Leu-His-Leu-Leu-Ala-Gln-Lys-Met-Phe-Asn-Asp-Phe-Asp-Gly-Thr-Leu-Leu-C-terminal: -Met-His.Lys-Val-Glu-Thr-Tyr-Leu-Thr-Val-Ala-Lys-Cys-Arg-Lys-Ser-Leu-Glu-Ala-Asn-Cys-Thr-Leu-OH; (III) molecular weight: about 22,000; (IV) isoelectric point: 5.6-5.7; and (V) soluble in an alkaline aqueous solution and hardly soluble or insoluble in neutral and acidic aqueous solutions.

    Fish growth hormone
    29.
    发明公开
    Fish growth hormone 失效
    Fischwachstumshormon。

    公开(公告)号：EP0157423A2

    公开(公告)日：1985-10-09

    申请号：EP85104089.9

    申请日：1985-04-04

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： Kawauchi, Hiroshi ,  Yamaguchi, Kazuo ,  Shirahata, Kunikatsu

    IPC分类号： C07K7/00 ,  A61K37/24

    CPC分类号： C07K14/461 ,  A61K38/00 ,  Y10S930/12

    摘要： A fish growth hormone provided by a purified extract obtained from the pituitary gland of a fish belonging to salmonoid; the hormone is a polypeptide having the following physicochemical properties:

    (I) amino acid composition: as indicated in table 1;
    (II) the sequences of 33 amino acids at the N-terminal and 23 amino acids at the C-terminal are as follows:

    N-terminal: H 2 N-Ile-Glu-Asn-Gln-Arg-Leu-Phe-Asn-Ile-Ala-Val-Ser-Arg-Val-Gln-His-Leu-His-Leu-Leu-Ala-Gln-Lys-Met-Phe-Asn-Asp-Phe-Asp-Gly-Thr-Leu-Leu-C-terminal: -Met-His.Lys-Val-Glu-Thr-Tyr-Leu-Thr-Val-Ala-Lys-Cys-Arg-Lys-Ser-Leu-Glu-Ala-Asn-Cys-Thr-Leu-OH;

    (III) molecular weight: about 22,000;
    (IV) isoelectric point: 5.6-5.7; and
    (V) soluble in an alkaline aqueous solution and hardly soluble or insoluble in neutral and acidic aqueous solutions.