Fish growth hormone
    3.
    发明公开
    Fish growth hormone 失效
    鱼生长激素

    公开(公告)号:EP0157423A3

    公开(公告)日:1987-04-22

    申请号:EP85104089

    申请日:1985-04-04

    IPC分类号: C07K07/00 A61K37/24

    摘要: A fish growth hormone provided by a purified extract obtained from the pituitary gland of a fish belonging to salmonoid; the hormone is a polypeptide having the following physicochemical properties:
    (I) amino acid composition: as indicated in table 1; (II) the sequences of 33 amino acids at the N-terminal and 23 amino acids at the C-terminal are as follows:
    N-terminal: H 2 N-Ile-Glu-Asn-Gln-Arg-Leu-Phe-Asn-Ile-Ala-Val-Ser-Arg-Val-Gln-His-Leu-His-Leu-Leu-Ala-Gln-Lys-Met-Phe-Asn-Asp-Phe-Asp-Gly-Thr-Leu-Leu-C-terminal: -Met-His.Lys-Val-Glu-Thr-Tyr-Leu-Thr-Val-Ala-Lys-Cys-Arg-Lys-Ser-Leu-Glu-Ala-Asn-Cys-Thr-Leu-OH; (III) molecular weight: about 22,000; (IV) isoelectric point: 5.6-5.7; and (V) soluble in an alkaline aqueous solution and hardly soluble or insoluble in neutral and acidic aqueous solutions.

    Fish growth hormone
    4.
    发明公开
    Fish growth hormone 失效
    Fischwachstumshormon。

    公开(公告)号:EP0157423A2

    公开(公告)日:1985-10-09

    申请号:EP85104089.9

    申请日:1985-04-04

    IPC分类号: C07K7/00 A61K37/24

    摘要: A fish growth hormone provided by a purified extract obtained from the pituitary gland of a fish belonging to salmonoid; the hormone is a polypeptide having the following physicochemical properties:

    (I) amino acid composition: as indicated in table 1;
    (II) the sequences of 33 amino acids at the N-terminal and 23 amino acids at the C-terminal are as follows:

    N-terminal: H 2 N-Ile-Glu-Asn-Gln-Arg-Leu-Phe-Asn-Ile-Ala-Val-Ser-Arg-Val-Gln-His-Leu-His-Leu-Leu-Ala-Gln-Lys-Met-Phe-Asn-Asp-Phe-Asp-Gly-Thr-Leu-Leu-C-terminal: -Met-His.Lys-Val-Glu-Thr-Tyr-Leu-Thr-Val-Ala-Lys-Cys-Arg-Lys-Ser-Leu-Glu-Ala-Asn-Cys-Thr-Leu-OH;

    (III) molecular weight: about 22,000;
    (IV) isoelectric point: 5.6-5.7; and
    (V) soluble in an alkaline aqueous solution and hardly soluble or insoluble in neutral and acidic aqueous solutions.

    Novel polypeptide
    10.
    发明公开
    Novel polypeptide 失效
    Neues Polypeptid。

    公开(公告)号:EP0272703A1

    公开(公告)日:1988-06-29

    申请号:EP87119157.3

    申请日:1987-12-23

    IPC分类号: C12N15/70 C07K15/00 C12P21/00

    摘要: Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different aminoacid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, and methods of producing the hG-CSF polypeptide derivatives using the microorganisms are described.

    摘要翻译: 具有衍生自人粒细胞集落刺激因子多肽的氨基酸序列的氨基酸序列的新型hG-CSF多肽衍生物通过用至少一个氨基酸的不同氨基酸和/或缺失取代至少一个氨基酸的重组质粒 含有编码这些hG-CSF多肽衍生物中的任何一个的DNA片段插入片段,携带这种质粒之一的微生物,以及使用微生物产生hG-CSF多肽衍生物的方法。