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公开(公告)号:EP0157423B1
公开(公告)日:1990-03-07
申请号:EP85104089.9
申请日:1985-04-04
CPC分类号: C07K14/461 , A61K38/00 , Y10S930/12
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公开(公告)号:EP0209068B1
公开(公告)日:1991-03-27
申请号:EP86109346.6
申请日:1986-07-09
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公开(公告)号:EP0157423A3
公开(公告)日:1987-04-22
申请号:EP85104089
申请日:1985-04-04
CPC分类号: C07K14/461 , A61K38/00 , Y10S930/12
摘要: A fish growth hormone provided by a purified extract obtained from the pituitary gland of a fish belonging to salmonoid; the hormone is a polypeptide having the following physicochemical properties:
(I) amino acid composition: as indicated in table 1; (II) the sequences of 33 amino acids at the N-terminal and 23 amino acids at the C-terminal are as follows:
N-terminal: H 2 N-Ile-Glu-Asn-Gln-Arg-Leu-Phe-Asn-Ile-Ala-Val-Ser-Arg-Val-Gln-His-Leu-His-Leu-Leu-Ala-Gln-Lys-Met-Phe-Asn-Asp-Phe-Asp-Gly-Thr-Leu-Leu-C-terminal: -Met-His.Lys-Val-Glu-Thr-Tyr-Leu-Thr-Val-Ala-Lys-Cys-Arg-Lys-Ser-Leu-Glu-Ala-Asn-Cys-Thr-Leu-OH; (III) molecular weight: about 22,000; (IV) isoelectric point: 5.6-5.7; and (V) soluble in an alkaline aqueous solution and hardly soluble or insoluble in neutral and acidic aqueous solutions.-
公开(公告)号:EP0157423A2
公开(公告)日:1985-10-09
申请号:EP85104089.9
申请日:1985-04-04
CPC分类号: C07K14/461 , A61K38/00 , Y10S930/12
摘要: A fish growth hormone provided by a purified extract obtained from the pituitary gland of a fish belonging to salmonoid; the hormone is a polypeptide having the following physicochemical properties:
(I) amino acid composition: as indicated in table 1;
(II) the sequences of 33 amino acids at the N-terminal and 23 amino acids at the C-terminal are as follows:
N-terminal: H 2 N-Ile-Glu-Asn-Gln-Arg-Leu-Phe-Asn-Ile-Ala-Val-Ser-Arg-Val-Gln-His-Leu-His-Leu-Leu-Ala-Gln-Lys-Met-Phe-Asn-Asp-Phe-Asp-Gly-Thr-Leu-Leu-C-terminal: -Met-His.Lys-Val-Glu-Thr-Tyr-Leu-Thr-Val-Ala-Lys-Cys-Arg-Lys-Ser-Leu-Glu-Ala-Asn-Cys-Thr-Leu-OH;
(III) molecular weight: about 22,000;
(IV) isoelectric point: 5.6-5.7; and
(V) soluble in an alkaline aqueous solution and hardly soluble or insoluble in neutral and acidic aqueous solutions.-
公开(公告)号:EP0272703B2
公开(公告)日:1997-10-15
申请号:EP87119157.3
申请日:1987-12-23
发明人: Kuga, Tetsuro , Komatsu, Yoshinori , Miyaji, Horomasa , Sato, Moriyuki , Okabe, Masami , Morimoto, Makoto , Itoh, Seiga , Yamasaki, Motoo , Yokoo, Yoshiharu , Yamaguchi, Kazuo
IPC分类号: C12N15/70 , C07K14/475 , C12P21/00
CPC分类号: C07K16/243 , A61K38/00 , C07K14/535 , C12N15/70
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公开(公告)号:EP0267629A2
公开(公告)日:1988-05-18
申请号:EP87116824.1
申请日:1987-11-13
CPC分类号: C07K14/545
摘要: Novel polypeptides having interleukin 1 (IL-1) activity and a method of producing the polypeptides which comprises producing human IL-1 by using gene engineering technique and treating the human IL-1 with an enzyme.
摘要翻译: 具有白细胞介素1(IL-1)活性的新型多肽及其制备方法,其包括使用基因工程技术生产人IL-1并用酶处理人IL-1。
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公开(公告)号:EP0209068A1
公开(公告)日:1987-01-21
申请号:EP86109346.6
申请日:1986-07-09
发明人: Yamaguchi, Kazuo , Saito, Akiko , Sekine, Susumu , Sato, Moriyuki , Itoh, Seiga , Shirahata, Kunikatsu , Hirano, Tetsuya , Kawauchi, Hiroshi
摘要: According to the present invention, a fish growth hormone was isolated from an organ culture broth of the pituitary gland of eels, and further a recombinant DNA incorporated with a DNA coding for the eel growth hormone polypeptide and a microorganism containing the recombinant DNA were obtained. They can be used for mass production of an eel growth hormone
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公开(公告)号:EP0272703B1
公开(公告)日:1993-07-28
申请号:EP87119157.3
申请日:1987-12-23
发明人: Kuga, Tetsuro , Komatsu, Yoshinori , Miyaji, Horomasa , Sato, Moriyuki , Okabe, Masami , Morimoto, Makoto , Itoh, Seiga , Yamasaki, Motoo , Yokoo, Yoshiharu , Yamaguchi, Kazuo
IPC分类号: C12N15/70 , C07K14/475 , C12P21/00
CPC分类号: C07K16/243 , A61K38/00 , C07K14/535 , C12N15/70
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公开(公告)号:EP0267629A3
公开(公告)日:1989-07-12
申请号:EP87116824.1
申请日:1987-11-13
CPC分类号: C07K14/545
摘要: Novel polypeptides having interleukin 1 (IL-1) activity and a method of producing the polypeptides which comprises producing human IL-1 by using gene engineering technique and treating the human IL-1 with an enzyme.
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公开(公告)号:EP0272703A1
公开(公告)日:1988-06-29
申请号:EP87119157.3
申请日:1987-12-23
发明人: Kuga, Tetsuro , Komatsu, Yoshinori , Miyaji, Horomasa , Sato, Moriyuki , Okabe, Masami , Morimoto, Makoto , Itoh, Seiga , Yamasaki, Motoo , Yokoo, Yoshiharu , Yamaguchi, Kazuo
CPC分类号: C07K16/243 , A61K38/00 , C07K14/535 , C12N15/70
摘要: Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different aminoacid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, and methods of producing the hG-CSF polypeptide derivatives using the microorganisms are described.
摘要翻译: 具有衍生自人粒细胞集落刺激因子多肽的氨基酸序列的氨基酸序列的新型hG-CSF多肽衍生物通过用至少一个氨基酸的不同氨基酸和/或缺失取代至少一个氨基酸的重组质粒 含有编码这些hG-CSF多肽衍生物中的任何一个的DNA片段插入片段,携带这种质粒之一的微生物,以及使用微生物产生hG-CSF多肽衍生物的方法。
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