公开(公告)号：EP1389210A1

公开(公告)日：2004-02-18

申请号：EP02740805.3

申请日：2002-05-22

申请人： Les Laboratoires Servier

发明人： HUSSON, Henri-Philippe ,  GIORGI-RENAULT, Sylviane ,  DESBENE, Stéphanie ,  HICKMAN, John ,  PIERRE, Alain ,  KRAUS-BERTHIER, Laurence ,  PFEIFFER, Bruno ,  RENARD, Pierre

IPC分类号： C07D491/14 ,  C07D497/14 ,  C07D491/04

CPC分类号： C07D491/04 ,  C07D491/14 ,  C07D497/14

摘要： The invention concerns a compound of formula (I), wherein (a) represents a single or double bond; (b) represents a cycle selected among (i), (ii), (iii), (iv), (v), (vi) and (vii). The inventive compounds, besides their novelty, exhibit very interesting antitumour properties.

公开(公告)号：EP2807159B1

公开(公告)日：2016-11-23

申请号：EP13704189.3

申请日：2013-01-23

申请人： Les Laboratoires Servier ,  Vernalis (R&D) Ltd.

发明人： LE DIGUARHER, Thierry ,  CASARA, Patrick ,  STARCK, Jérôme-Benoît ,  HENLIN, Jean-Michel ,  DAVIDSON, James Edward Paul ,  MURRAY, James Brooke ,  GRAHAM, Christopher John ,  CHEN, I-Jen ,  GENESTE, Olivier ,  HICKMAN, John ,  DEPIL, Stéphane ,  LE TIRAN, Arnaud ,  NYERGES, Miklos ,  DE NANTEUIL, Guillaume

IPC分类号： C07D471/04 ,  C07D487/04 ,  C07D491/052 ,  A61K31/4353 ,  A61K31/436 ,  A61K31/407 ,  A61P35/00 ,  A61P37/00

CPC分类号： A61K31/5377 ,  A61K31/4725 ,  A61K31/475 ,  A61K31/496 ,  A61K31/5383 ,  A61K31/541 ,  A61K31/55 ,  A61K31/553 ,  A61K45/06 ,  A61N5/10 ,  A61N5/1001 ,  C07D207/30 ,  C07D211/06 ,  C07D211/80 ,  C07D471/00 ,  C07D471/04 ,  C07D487/04 ,  C07D491/052 ,  C07D498/04

公开(公告)号：EP2807159A1

公开(公告)日：2014-12-03

申请号：EP13704189.3

申请日：2013-01-23

申请人： Les Laboratoires Servier ,  Vernalis (R&D) Ltd.

发明人： LE DIGUARHER, Thierry ,  CASARA, Patrick ,  STARCK, Jérôme-Benoît ,  HENLIN, Jean-Michel ,  DAVIDSON, James Edward Paul ,  MURRAY, James Brooke ,  GRAHAM, Christopher John ,  CHEN, I-Jen ,  GENESTE, Olivier ,  HICKMAN, John ,  DEPIL, Stéphane ,  LE TIRAN, Arnaud ,  NYERGES, Miklos ,  DE NANTEUIL, Guillaume

IPC分类号： C07D471/00 ,  C07D471/04 ,  C07D487/04 ,  C07D491/052 ,  A61K31/4353 ,  A61K31/436 ,  A61K31/407 ,  A61P35/00 ,  A61P37/00

CPC分类号： A61K31/5377 ,  A61K31/4725 ,  A61K31/475 ,  A61K31/496 ,  A61K31/5383 ,  A61K31/541 ,  A61K31/55 ,  A61K31/553 ,  A61K45/06 ,  A61N5/10 ,  A61N5/1001 ,  C07D207/30 ,  C07D211/06 ,  C07D211/80 ,  C07D471/00 ,  C07D471/04 ,  C07D487/04 ,  C07D491/052 ,  C07D498/04

摘要： Compounds of formula (I) wherein R
a , Rb, Rc, Rd, R1, R2, R3, R4, R5; X, Y and Het are as defined in the description.

摘要翻译： 其中Ra，Rb，RC，RD，R1，R2，R3，R4，R5，X，Y和Het如在说明书中定义。 医药产品包含相同哪些是治疗病理涉及在细胞凋亡中赤字有用：如癌症，自身免疫疾病，以及免疫系统的疾病。

公开(公告)号：EP2303880A2

公开(公告)日：2011-04-06

申请号：EP09784263.7

申请日：2009-07-10

申请人： Les Laboratoires Servier

发明人： CASARA, Patrick ,  LE DIGUARHER, Thierry ,  DURAND, Didier ,  GENESTE, Olivier ,  HICKMAN, John

IPC分类号： C07D471/04 ,  C07D487/04 ,  A61K31/498 ,  A61P35/00 ,  C07D471/14 ,  C07D241/04 ,  C07D213/36 ,  C07D211/70 ,  C07D207/20 ,  A61K31/4985

CPC分类号： C07D471/04 ,  C07D487/04

摘要： Compounds of formula (I) in which: A is a (hetero)aromatic or non-(hetero)aromatic ring containing 5, 6 or 7 ring members, Z
1 , Z
2 and Z
3 are, independently of one another, a CH group or a nitrogen atom, with at least one of these three groups being a nitrogen atom, X is an alkylene chain as defined in the description, R
2 is an aryl or heteroaryl group, and the R
1 group is a group of formula (II) as defined in the description.

公开(公告)号：EP1554277A1

公开(公告)日：2005-07-20

申请号：EP03778389.1

申请日：2003-10-14

申请人： LES LABORATOIRES SERVIER

发明人： PRUDHOMME, Michelle ,  HUGON, Bernadette ,  ANIZON, Fabrice ,  HICKMAN, John ,  PIERRE, Alain ,  GOLSTEYN, Roy ,  RENARD, Pierre ,  PFEIFFER, Bruno

IPC分类号： C07D471/22 ,  C07D487/14 ,  A61K31/437 ,  A61K31/407 ,  A61P35/00

CPC分类号： C07D487/14

摘要： The invention concerns compounds of formula (I), wherein: Z represents a group of formula U-V such as defined in the description; W1 represents, with the carbon atoms to which it is bound, a phenyl group or a pyridinyl group; W2 is such as defined in the description; X1, X2 represent each a hydrogen atom, a hydroxy, alkoxy, mercapto or alkylthio group; Y1, Y2 represent each a hydrogen atom, or X1 and Y1, X2 and Y2 represent each a hydrogen atom, a hydroxy, a linear or branched C1-C6 alkoxy, mercapto, and linear or branched C1-C6 alkythio group; R1 is such as defined in the description; Q represents an oxygen atom or a NR2 group such as defined in the description.

公开(公告)号：EP1409486A1

公开(公告)日：2004-04-21

申请号：EP02767534.7

申请日：2002-06-28

申请人： LES LABORATOIRES SERVIER

发明人： PRUDHOMME, Michelle ,  MARMINON, Christelle ,  ROUTIER, Sylvain ,  COUDERT, Gérard ,  MEROUR, Jean-Yves ,  HICKMAN, John ,  PIERRE, Alain ,  RENARD, Pierre ,  PFEIFFER, Bruno

IPC分类号： C07D471/22 ,  C07D498/22 ,  A61K31/44

CPC分类号： C07H15/252

摘要： Compounds of formula (I) wherein: WI and W2 represent, with the carbon atoms to which they are bound, a phenyl group or a pyridinyl group, and at least one of the groups W1 or W2 represent a pyridinyl group; R1 and R2 each represent a group of formula U-V as defined in the description, X and X1 each represent a hydrogen atom, a hydroxy, alkoxy, mercapto or alkylthio group; Y and Y1 each represent a hydrogen atom; or X and Y, X1 and Y1 represent, together with the carbon atom that they include, a carbonyl or thiocarbonyl group; R4 and R5 are as defined in the description; Q1, Q2 represent a hydrogen atom, or Q1 and Q2, together with the carbon atoms that they include, form an aromatic link. The inventive compounds are used in medicaments.