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1.发明授权
公开(公告)号：EP2807159B1
公开(公告)日：2016-11-23
申请号：EP13704189.3
申请日：2013-01-23
发明人： LE DIGUARHER, Thierry , CASARA, Patrick , STARCK, Jérôme-Benoît , HENLIN, Jean-Michel , DAVIDSON, James Edward Paul , MURRAY, James Brooke , GRAHAM, Christopher John , CHEN, I-Jen , GENESTE, Olivier , HICKMAN, John , DEPIL, Stéphane , LE TIRAN, Arnaud , NYERGES, Miklos , DE NANTEUIL, Guillaume
IPC分类号： C07D471/04 , C07D487/04 , C07D491/052 , A61K31/4353 , A61K31/436 , A61K31/407 , A61P35/00 , A61P37/00
CPC分类号： A61K31/5377 , A61K31/4725 , A61K31/475 , A61K31/496 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/553 , A61K45/06 , A61N5/10 , A61N5/1001 , C07D207/30 , C07D211/06 , C07D211/80 , C07D471/00 , C07D471/04 , C07D487/04 , C07D491/052 , C07D498/04
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2.发明公开
公开(公告)号：EP2807159A1
公开(公告)日：2014-12-03
申请号：EP13704189.3
申请日：2013-01-23
发明人： LE DIGUARHER, Thierry , CASARA, Patrick , STARCK, Jérôme-Benoît , HENLIN, Jean-Michel , DAVIDSON, James Edward Paul , MURRAY, James Brooke , GRAHAM, Christopher John , CHEN, I-Jen , GENESTE, Olivier , HICKMAN, John , DEPIL, Stéphane , LE TIRAN, Arnaud , NYERGES, Miklos , DE NANTEUIL, Guillaume
IPC分类号： C07D471/00 , C07D471/04 , C07D487/04 , C07D491/052 , A61K31/4353 , A61K31/436 , A61K31/407 , A61P35/00 , A61P37/00
CPC分类号： A61K31/5377 , A61K31/4725 , A61K31/475 , A61K31/496 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/553 , A61K45/06 , A61N5/10 , A61N5/1001 , C07D207/30 , C07D211/06 , C07D211/80 , C07D471/00 , C07D471/04 , C07D487/04 , C07D491/052 , C07D498/04
摘要： Compounds of formula (I) wherein R
a , Rb, Rc, Rd, R1, R2, R3, R4, R5; X, Y and Het are as defined in the description.摘要翻译： 其中Ra，Rb，RC，RD，R1，R2，R3，R4，R5，X，Y和Het如在说明书中定义。 医药产品包含相同哪些是治疗病理涉及在细胞凋亡中赤字有用：如癌症，自身免疫疾病，以及免疫系统的疾病。
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3.发明公开UBIQUITIN SPECIFIC PROTEASES RESPONSIBLE FOR MCL-1 STABILITY AND USES THEREOF 审中-公开泛素蛋白酶FOR MCL-1稳定性和使用
公开(公告)号：EP2344666A2
公开(公告)日：2011-07-20
申请号：EP09799134.3
申请日：2009-10-29
CPC分类号： G01N33/5011 , A61K38/00 , C12Q1/37
摘要： Use of a polypeptide selected from the group consisting of USP13, USP26, USP38, USP42 or USP46 as a screening tool for an agent for treating cancer.
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4.发明公开MOTIF DE LA PROTEINE BECLIN INTERAGISSANT AVEC LES MEMBRES ANTI-APOPTOTIQUES DE LA FAMILLE DE PROTEINES BCL-2 ET UTILISATIONS 审中-公开与之交互BECLIN蛋白场景，及其用途抗凋亡Bcl-2蛋白家族成员
公开(公告)号：EP1844066A1
公开(公告)日：2007-10-17
申请号：EP06709201.5
申请日：2006-01-31
IPC分类号： C07K14/435 , G01N33/68 , C12N15/12 , C12N15/63 , G01N33/566 , G01N33/58 , A61K38/17 , A61P35/00
CPC分类号： G01N33/57496 , C07K14/4747 , G01N33/542 , G01N2510/00
摘要： The invention relates to a method of identifying modulators of programmed cell death, comprising an interaction between a motif of Beclin protein and an anti-apoptotic member of the family of Bcl-2 proteins and the detection of said interaction be means of fluorescence polarisation. The modulators identified on the basis of said method are administered to cancer patients in order to induce apoptotic- and/or autophagic-type programmed cell death. The invention also relates to a motif of the Beclin protein which can interact with an anti-apoptic member of the family of Bcl-2 proteins and to the use thereof in order to induce programmed cell death in a cancer patient.
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5.发明公开DERIVES DE BENZO (E) (1,4) OXAZINO (3,2-G) ISOINDOLE SUBSTI TUES, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 有权苯并（E）（1.4）恶嗪（3.2克）异吲哚衍生物，用于生产和含有这些药物组合物
公开(公告)号：EP1556387A1
公开(公告)日：2005-07-27
申请号：EP03809362.1
申请日：2003-10-17
发明人： COUDERT, Gérard , LEPIFRE, Franck , CAIGNARD, Daniel-Henri , RENARD, Pierre , HICKMAN, John , PIERRE, Alain , KRAUS-BERTHIER, Laurence
IPC分类号： C07D498/04 , A61K31/535 , C07D498/14 , C07D265/38
CPC分类号： C07D497/04 , C07D497/14
摘要： The invention concerns compounds of formula (I), wherein: W1 represents with the carbon atoms whereto it is bound, a phenyl group or a pyridinyl group; Z represents a group selected among a hydrogen atom, halogen, a linear or branched C1-C6 alkyl, aryl, linear or branched C1-C6 arylalkyl, aryloxy, linear or branched C1-C6 arylalkoxy, hydroxy, linear or branched C1-C6 alkoxy group; R1 is such as defined in the description; R2 represents a hydrogen atom or a group of formula -CH2CH2O-R8; R3, R4 represent each a hydrogen atom, a linear or branched C1-C6 alkyl, aryl, linear or branched C1-C6 aryalkyl group; n represents an integer between 1 and 6 inclusive. The invention is useful for preparing medicines.
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6.发明公开NOUVEAUX DERIVES D'HYDROXYALKYLE INDOLOCARBAZOLE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 审中-公开羟INDOLOKARBAZOLDERIVATE，其制造方法相同，药物组合物含
公开(公告)号：EP1438320A1
公开(公告)日：2004-07-21
申请号：EP02796813.0
申请日：2002-10-21
发明人： PRUDHOMME, Michelle , MARMINON, Christelle , MOREAU, Pascale , HICKMAN, John , PIERRE, Alain , PFEIFFER, Bruno , RENARD, Pierre , BIZOT-ESPIARD, Jean-Guy
IPC分类号： C07H19/23 , A61K31/7056 , A61P25/00 , A61P35/00
CPC分类号： C07H19/23
摘要： The invention concerns a compound of formula (I), wherein: R1 and R2 represent each a group selected among hydrogen, alkyl, arylalkyl, hydroxy, hydroxylalkyl, dihydroxyalkyl, alkoxy, alkoxyalkyl, amino and aminoalkyl (optionally substituted); Ra and Rb represent each an alkylene chain; X1 and X2 represent each a group selected among hydroxy, alkoxy, aryloxy, arylalkoxy, alkyl, amino (optionally substituted), halogen, alkylcarbonyloxy and azido; X4 represent a methylidene group or a group of formula -Rc-X1 such as defined in their description; their isomers and their addition salts to a pharmaceutically acceptable acid or base. The invention is for use as medicines.
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7.发明授权NOUVEAU PEPTIDE INTERAGISSANT AVEC LES PROTEINES ANTI-APOPTOTIQUES DE LA FAMILLE BCL-2 有权肽具有抗凋亡蛋白家族BCL-2相互作用
公开(公告)号：EP1651668B1
公开(公告)日：2009-07-15
申请号：EP04786256.0
申请日：2004-08-04
IPC分类号： C07K14/47
CPC分类号： C07K14/4747 , C07K14/4702
摘要： The invention relates to the identification of a novel peptide interacting with Bcl-2, Bcl-W and/or Bcl-XL anti-apoptotic proteins and to screening methods for identifying the modulators of said interactions.
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8.发明公开
公开(公告)号：EP1910377A2
公开(公告)日：2008-04-16
申请号：EP06794288.8
申请日：2006-08-04
IPC分类号： C07D491/22 , C07D471/14 , A61K31/4745 , A61P35/00
CPC分类号： C07D471/14
摘要： Compounds of formula (I), wherein R1, R2, R3, R4, R5, R80, R90, R81, R91, AIk and G are such as defined in the description, can be used for drugs.
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9.发明公开NOUVEAUX DERIVES DE 1,4 BENZODIOXINO 2,3-e ISOINDOLE SUBSTITUES, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 有权取代的[1,4]苯并二恶英并[2,3-E]异吲哚衍生物，PROCESS FOR它们的生产和药物组合物
公开(公告)号：EP1587810A1
公开(公告)日：2005-10-26
申请号：EP03809363.9
申请日：2003-10-17
发明人： COUDERT, Gérard , AYERBE, Nathalie , LEPIFRE, Franck , ROUTIER, Sylvain , CAIGNARD, Daniel-Henri , RENARD, Pierre , HICKMAN, John , PIERRE, Alain , LEONCE, Stéphane
IPC分类号： C07D498/14 , C07D498/22 , C07D491/14 , C07D487/04 , A61P35/00 , A61K31/5365
CPC分类号： C07D471/14 , C07D487/04 , C07D491/14
摘要： The invention concerns compounds of formula (I), wherein: A is such as described in the description; Y represents a group selected among an oxygen atom or a methylene group; R2 represents a hydrogen atom, in which case: R3 represents a group selected among a hydrogen atom, a C1-C6 linear or branched alkyl, aryl, linear or branched C1-C6 arylalkyl group, or SO2CF3, or R2 and R3 form a bond; R1 represents a group selected among a hydrogen atom, a C1-C6 linear or branched alkyl, aryl, linear or branched C1-C6 arylalkyl group, or a linear or branched C1-C6 alkylene chain; Z1 and Z2 represent each a hydrogen atom or Z1 and Z2 form together, with the carbon atoms bearing them, a phenyl group. The invention is useful for preparing medicines.
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10.发明公开
公开(公告)号：EP1292597A1
公开(公告)日：2003-03-19
申请号：EP01947525.0
申请日：2001-06-19
发明人： MONNERET, Claude , BERTOUNESQUE, Emmanuel , MERESSE, Philippe , ATASSI, Ghanem , PIERRE, Alain , HICKMAN, John , PFEIFFER, Bruno , RENARD, Pierre
IPC分类号： C07D493/04 , A61K31/365 , A61P35/00
CPC分类号： C07D493/04 , Y02P20/55
摘要： A compound selected from these of formula (I):wherein:R1 represents hydrogen, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl or phosphono,R2 represents oxygen or sulphur,R3 represents hydrogen or alkyl, cycloalkyl or arylalkyl,X represents linear or branched (C1-C6)alkylene,R4 represents a group selected from amino optionally substituted by one or two groups, -N(R3)-X1-OR5 wherein R3, X1 and R5 are as defined in the description, -N(R3)-X1-NR6R7 wherein R3, X1, R6 and R7 are as defined in the description, hydroxy, alkoxy, aryloxy, -O-X1-OR5 wherein R5 and X1 are as defined in the description, and -O-X1-NR6R7 wherein R6, R7 and X1 are as defined in the description,its isomers, and also addition salts thereof with a pharmaceutically acceptable acid or base, and medical products containing the same which are useful in the treatment of cancer.
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